Concept for using magnetic particle imaging for intraoperative margin analysis in breast-conserving surgery

Abstract Breast-conserving surgery (BCS) is a commonly utilized treatment for early stage breast cancers but has relatively high reexcision rates due to post-surgical identification of positive margins. A fast, specific, sensitive, easy-to-use tool for assessing margins intraoperatively could reduce...

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Autores principales:	Erica E. Mason, Eli Mattingly, Konstantin Herb, Monika Śliwiak, Sofia Franconi, Clarissa Zimmerman Cooley, Priscilla J. Slanetz, Lawrence L. Wald
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9926859ee06740ea8ba82500dae17e65
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spelling	oai:doaj.org-article:9926859ee06740ea8ba82500dae17e652021-12-02T16:10:24ZConcept for using magnetic particle imaging for intraoperative margin analysis in breast-conserving surgery10.1038/s41598-021-92644-82045-2322https://doaj.org/article/9926859ee06740ea8ba82500dae17e652021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92644-8https://doaj.org/toc/2045-2322Abstract Breast-conserving surgery (BCS) is a commonly utilized treatment for early stage breast cancers but has relatively high reexcision rates due to post-surgical identification of positive margins. A fast, specific, sensitive, easy-to-use tool for assessing margins intraoperatively could reduce the need for additional surgeries, and while many techniques have been explored, the clinical need is still unmet. We assess the potential of Magnetic Particle Imaging (MPI) for intraoperative margin assessment in BCS, using a passively or actively tumor-targeted iron oxide agent and two hardware devices: a hand-held Magnetic Particle detector for identifying residual tumor in the breast, and a small-bore MPI scanner for quickly imaging the tumor distribution in the excised specimen. Here, we present both hardware systems and demonstrate proof-of-concept detection and imaging of clinically relevant phantoms.Erica E. MasonEli MattinglyKonstantin HerbMonika ŚliwiakSofia FranconiClarissa Zimmerman CooleyPriscilla J. SlanetzLawrence L. WaldNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Erica E. Mason Eli Mattingly Konstantin Herb Monika Śliwiak Sofia Franconi Clarissa Zimmerman Cooley Priscilla J. Slanetz Lawrence L. Wald Concept for using magnetic particle imaging for intraoperative margin analysis in breast-conserving surgery
description	Abstract Breast-conserving surgery (BCS) is a commonly utilized treatment for early stage breast cancers but has relatively high reexcision rates due to post-surgical identification of positive margins. A fast, specific, sensitive, easy-to-use tool for assessing margins intraoperatively could reduce the need for additional surgeries, and while many techniques have been explored, the clinical need is still unmet. We assess the potential of Magnetic Particle Imaging (MPI) for intraoperative margin assessment in BCS, using a passively or actively tumor-targeted iron oxide agent and two hardware devices: a hand-held Magnetic Particle detector for identifying residual tumor in the breast, and a small-bore MPI scanner for quickly imaging the tumor distribution in the excised specimen. Here, we present both hardware systems and demonstrate proof-of-concept detection and imaging of clinically relevant phantoms.
format	article
author	Erica E. Mason Eli Mattingly Konstantin Herb Monika Śliwiak Sofia Franconi Clarissa Zimmerman Cooley Priscilla J. Slanetz Lawrence L. Wald
author_facet	Erica E. Mason Eli Mattingly Konstantin Herb Monika Śliwiak Sofia Franconi Clarissa Zimmerman Cooley Priscilla J. Slanetz Lawrence L. Wald
author_sort	Erica E. Mason
title	Concept for using magnetic particle imaging for intraoperative margin analysis in breast-conserving surgery
title_short	Concept for using magnetic particle imaging for intraoperative margin analysis in breast-conserving surgery
title_full	Concept for using magnetic particle imaging for intraoperative margin analysis in breast-conserving surgery
title_fullStr	Concept for using magnetic particle imaging for intraoperative margin analysis in breast-conserving surgery
title_full_unstemmed	Concept for using magnetic particle imaging for intraoperative margin analysis in breast-conserving surgery
title_sort	concept for using magnetic particle imaging for intraoperative margin analysis in breast-conserving surgery
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9926859ee06740ea8ba82500dae17e65
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Concept for using magnetic particle imaging for intraoperative margin analysis in breast-conserving surgery

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