LSD1-mediated demethylation of OCT4 safeguards pluripotent stem cells by maintaining the transcription of PORE-motif-containing genes

LSD1-mediated demethylation of OCT4 safeguards pluripotent stem cells by maintaining the transcription of PORE-motif-containing genes

Abstract Reversible lysine methylation is essential for regulating histones and emerges to critically regulate non-histone proteins as well. Here we show that the master transcription factor OCT4 in pluripotent stem cells (PSCs) was methylated at multiple lysine residues. LSD1 that is highly express...

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Autores principales: Songsong Dan, Yuelin Song, Xiaotao Duan, Xiao Pan, Cheng Chen, Shiqi She, Tong Su, Jingchao Li, Xinyu Chen, Yanwen Zhou, Wenjie Chen, Xiaobing Zhang, Xiaoyun Pan, Ying-Jie Wang, Bo Kang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/9929f6a3d4b34a3cb2452e62d3f23082
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