SARS-CoV-2 does not have a strong effect on the nasopharyngeal microbial composition

Abstract The coronavirus disease 2019 (COVID-19) has rapidly spread around the world, impacting the lives of many individuals. Growing evidence suggests that the nasopharyngeal and respiratory tract microbiome are influenced by various health and disease conditions, including the presence and the se...

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Autores principales:	Tzipi Braun, Shiraz Halevi, Rotem Hadar, Gilate Efroni, Efrat Glick Saar, Natahan Keller, Amnon Amir, Sharon Amit, Yael Haberman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/992bb0df828740e8bd655ac07e37b2e6
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spelling	oai:doaj.org-article:992bb0df828740e8bd655ac07e37b2e62021-12-02T17:15:16ZSARS-CoV-2 does not have a strong effect on the nasopharyngeal microbial composition10.1038/s41598-021-88536-62045-2322https://doaj.org/article/992bb0df828740e8bd655ac07e37b2e62021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88536-6https://doaj.org/toc/2045-2322Abstract The coronavirus disease 2019 (COVID-19) has rapidly spread around the world, impacting the lives of many individuals. Growing evidence suggests that the nasopharyngeal and respiratory tract microbiome are influenced by various health and disease conditions, including the presence and the severity of different viral disease. To evaluate the potential interactions between Severe Acute Respiratory Syndrome Corona 2 (SARS-CoV-2) and the nasopharyngeal microbiome. Microbial composition of nasopharyngeal swab samples submitted to the clinical microbiology lab for suspected SARS-CoV-2 infections was assessed using 16S amplicon sequencing. The study included a total of 55 nasopharyngeal samples from 33 subjects, with longitudinal sampling available for 12 out of the 33 subjects. 21 of the 33 subjects had at least one positive COVID-19 PCR results as determined by the clinical microbiology lab. Inter-personal variation was the strongest factor explaining > 75% of the microbial variation, irrespective of the SARS-CoV-2 status. No significant effect of SARS-CoV-2 on the nasopharyngeal microbial community was observed using multiple analysis methods. These results indicate that unlike some other viruses, for which an effect on the microbial composition was noted, SARS-CoV-2 does not have a strong effect on the nasopharynx microbial habitants.Tzipi BraunShiraz HaleviRotem HadarGilate EfroniEfrat Glick SaarNatahan KellerAmnon AmirSharon AmitYael HabermanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tzipi Braun Shiraz Halevi Rotem Hadar Gilate Efroni Efrat Glick Saar Natahan Keller Amnon Amir Sharon Amit Yael Haberman SARS-CoV-2 does not have a strong effect on the nasopharyngeal microbial composition
description	Abstract The coronavirus disease 2019 (COVID-19) has rapidly spread around the world, impacting the lives of many individuals. Growing evidence suggests that the nasopharyngeal and respiratory tract microbiome are influenced by various health and disease conditions, including the presence and the severity of different viral disease. To evaluate the potential interactions between Severe Acute Respiratory Syndrome Corona 2 (SARS-CoV-2) and the nasopharyngeal microbiome. Microbial composition of nasopharyngeal swab samples submitted to the clinical microbiology lab for suspected SARS-CoV-2 infections was assessed using 16S amplicon sequencing. The study included a total of 55 nasopharyngeal samples from 33 subjects, with longitudinal sampling available for 12 out of the 33 subjects. 21 of the 33 subjects had at least one positive COVID-19 PCR results as determined by the clinical microbiology lab. Inter-personal variation was the strongest factor explaining > 75% of the microbial variation, irrespective of the SARS-CoV-2 status. No significant effect of SARS-CoV-2 on the nasopharyngeal microbial community was observed using multiple analysis methods. These results indicate that unlike some other viruses, for which an effect on the microbial composition was noted, SARS-CoV-2 does not have a strong effect on the nasopharynx microbial habitants.
format	article
author	Tzipi Braun Shiraz Halevi Rotem Hadar Gilate Efroni Efrat Glick Saar Natahan Keller Amnon Amir Sharon Amit Yael Haberman
author_facet	Tzipi Braun Shiraz Halevi Rotem Hadar Gilate Efroni Efrat Glick Saar Natahan Keller Amnon Amir Sharon Amit Yael Haberman
author_sort	Tzipi Braun
title	SARS-CoV-2 does not have a strong effect on the nasopharyngeal microbial composition
title_short	SARS-CoV-2 does not have a strong effect on the nasopharyngeal microbial composition
title_full	SARS-CoV-2 does not have a strong effect on the nasopharyngeal microbial composition
title_fullStr	SARS-CoV-2 does not have a strong effect on the nasopharyngeal microbial composition
title_full_unstemmed	SARS-CoV-2 does not have a strong effect on the nasopharyngeal microbial composition
title_sort	sars-cov-2 does not have a strong effect on the nasopharyngeal microbial composition
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/992bb0df828740e8bd655ac07e37b2e6
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SARS-CoV-2 does not have a strong effect on the nasopharyngeal microbial composition

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