Cep57 is a Mis12-interacting kinetochore protein involved in kinetochore targeting of Mad1–Mad2

The spindle assembly checkpoint relies on the accumulation of Mad1-Mad2 at kinetochores, but the mechanism of regulation is not known. Here Zhou et al. show that the centrosomal protein Cep57 interacts with the kinetochore proteins Mis12 and Mad1, and regulates the recruitment of Mad1/Mad2 to kineto...

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Autores principales:	Haining Zhou, Tianning Wang, Tao Zheng, Junlin Teng, Jianguo Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/99311ef499af4aba8e07c1289d0dfbc0
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spelling	oai:doaj.org-article:99311ef499af4aba8e07c1289d0dfbc02021-12-02T14:38:57ZCep57 is a Mis12-interacting kinetochore protein involved in kinetochore targeting of Mad1–Mad210.1038/ncomms101512041-1723https://doaj.org/article/99311ef499af4aba8e07c1289d0dfbc02016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10151https://doaj.org/toc/2041-1723The spindle assembly checkpoint relies on the accumulation of Mad1-Mad2 at kinetochores, but the mechanism of regulation is not known. Here Zhou et al. show that the centrosomal protein Cep57 interacts with the kinetochore proteins Mis12 and Mad1, and regulates the recruitment of Mad1/Mad2 to kinetochores.Haining ZhouTianning WangTao ZhengJunlin TengJianguo ChenNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Haining Zhou Tianning Wang Tao Zheng Junlin Teng Jianguo Chen Cep57 is a Mis12-interacting kinetochore protein involved in kinetochore targeting of Mad1–Mad2
description	The spindle assembly checkpoint relies on the accumulation of Mad1-Mad2 at kinetochores, but the mechanism of regulation is not known. Here Zhou et al. show that the centrosomal protein Cep57 interacts with the kinetochore proteins Mis12 and Mad1, and regulates the recruitment of Mad1/Mad2 to kinetochores.
format	article
author	Haining Zhou Tianning Wang Tao Zheng Junlin Teng Jianguo Chen
author_facet	Haining Zhou Tianning Wang Tao Zheng Junlin Teng Jianguo Chen
author_sort	Haining Zhou
title	Cep57 is a Mis12-interacting kinetochore protein involved in kinetochore targeting of Mad1–Mad2
title_short	Cep57 is a Mis12-interacting kinetochore protein involved in kinetochore targeting of Mad1–Mad2
title_full	Cep57 is a Mis12-interacting kinetochore protein involved in kinetochore targeting of Mad1–Mad2
title_fullStr	Cep57 is a Mis12-interacting kinetochore protein involved in kinetochore targeting of Mad1–Mad2
title_full_unstemmed	Cep57 is a Mis12-interacting kinetochore protein involved in kinetochore targeting of Mad1–Mad2
title_sort	cep57 is a mis12-interacting kinetochore protein involved in kinetochore targeting of mad1–mad2
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/99311ef499af4aba8e07c1289d0dfbc0
work_keys_str_mv	AT hainingzhou cep57isamis12interactingkinetochoreproteininvolvedinkinetochoretargetingofmad1mad2 AT tianningwang cep57isamis12interactingkinetochoreproteininvolvedinkinetochoretargetingofmad1mad2 AT taozheng cep57isamis12interactingkinetochoreproteininvolvedinkinetochoretargetingofmad1mad2 AT junlinteng cep57isamis12interactingkinetochoreproteininvolvedinkinetochoretargetingofmad1mad2 AT jianguochen cep57isamis12interactingkinetochoreproteininvolvedinkinetochoretargetingofmad1mad2
_version_	1718390785641021440

Cep57 is a Mis12-interacting kinetochore protein involved in kinetochore targeting of Mad1–Mad2

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