Activation mechanism of a small prototypic Rec-GGDEF diguanylate cyclase

As part of two-component systems, diguanylate cyclases (DGCs) are activated by phosphorylation. Structural and computational analyses of DgcR, a model DGC, reveal the phosphorylation-induced conformational changes and the activation mechanism likely shared by many DGCs with N-terminal coiled-coil li...

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Autores principales:	Raphael D. Teixeira, Fabian Holzschuh, Tilman Schirmer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/993709a2a8174e36ab5ef612d935d41e
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spelling	oai:doaj.org-article:993709a2a8174e36ab5ef612d935d41e2021-12-02T14:25:17ZActivation mechanism of a small prototypic Rec-GGDEF diguanylate cyclase10.1038/s41467-021-22492-72041-1723https://doaj.org/article/993709a2a8174e36ab5ef612d935d41e2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22492-7https://doaj.org/toc/2041-1723As part of two-component systems, diguanylate cyclases (DGCs) are activated by phosphorylation. Structural and computational analyses of DgcR, a model DGC, reveal the phosphorylation-induced conformational changes and the activation mechanism likely shared by many DGCs with N-terminal coiled-coil linkers.Raphael D. TeixeiraFabian HolzschuhTilman SchirmerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Raphael D. Teixeira Fabian Holzschuh Tilman Schirmer Activation mechanism of a small prototypic Rec-GGDEF diguanylate cyclase
description	As part of two-component systems, diguanylate cyclases (DGCs) are activated by phosphorylation. Structural and computational analyses of DgcR, a model DGC, reveal the phosphorylation-induced conformational changes and the activation mechanism likely shared by many DGCs with N-terminal coiled-coil linkers.
format	article
author	Raphael D. Teixeira Fabian Holzschuh Tilman Schirmer
author_facet	Raphael D. Teixeira Fabian Holzschuh Tilman Schirmer
author_sort	Raphael D. Teixeira
title	Activation mechanism of a small prototypic Rec-GGDEF diguanylate cyclase
title_short	Activation mechanism of a small prototypic Rec-GGDEF diguanylate cyclase
title_full	Activation mechanism of a small prototypic Rec-GGDEF diguanylate cyclase
title_fullStr	Activation mechanism of a small prototypic Rec-GGDEF diguanylate cyclase
title_full_unstemmed	Activation mechanism of a small prototypic Rec-GGDEF diguanylate cyclase
title_sort	activation mechanism of a small prototypic rec-ggdef diguanylate cyclase
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/993709a2a8174e36ab5ef612d935d41e
work_keys_str_mv	AT raphaeldteixeira activationmechanismofasmallprototypicrecggdefdiguanylatecyclase AT fabianholzschuh activationmechanismofasmallprototypicrecggdefdiguanylatecyclase AT tilmanschirmer activationmechanismofasmallprototypicrecggdefdiguanylatecyclase
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Activation mechanism of a small prototypic Rec-GGDEF diguanylate cyclase

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