CKAMP44 modulates integration of visual inputs in the lateral geniculate nucleus

The function of receptor desensitization in vivo is not well understood. Here, the authors show that deletion of CKAMP44, an AMPAR auxiliary protein that modulates desensitization of AMPAR currents, affects synaptic facilitation at retinogeniculate synapses and visually-evoked firing in awake mice.

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Detalles Bibliográficos
Autores principales: Xufeng Chen, Muhammad Aslam, Tim Gollisch, Kevin Allen, Jakob von Engelhardt
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/993e2dfbe56d42b8b16b0d79d74bc768
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Sumario:The function of receptor desensitization in vivo is not well understood. Here, the authors show that deletion of CKAMP44, an AMPAR auxiliary protein that modulates desensitization of AMPAR currents, affects synaptic facilitation at retinogeniculate synapses and visually-evoked firing in awake mice.