CKAMP44 modulates integration of visual inputs in the lateral geniculate nucleus

The function of receptor desensitization in vivo is not well understood. Here, the authors show that deletion of CKAMP44, an AMPAR auxiliary protein that modulates desensitization of AMPAR currents, affects synaptic facilitation at retinogeniculate synapses and visually-evoked firing in awake mice.

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Autores principales:	Xufeng Chen, Muhammad Aslam, Tim Gollisch, Kevin Allen, Jakob von Engelhardt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/993e2dfbe56d42b8b16b0d79d74bc768
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spelling	oai:doaj.org-article:993e2dfbe56d42b8b16b0d79d74bc7682021-12-02T15:34:06ZCKAMP44 modulates integration of visual inputs in the lateral geniculate nucleus10.1038/s41467-017-02415-12041-1723https://doaj.org/article/993e2dfbe56d42b8b16b0d79d74bc7682018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02415-1https://doaj.org/toc/2041-1723The function of receptor desensitization in vivo is not well understood. Here, the authors show that deletion of CKAMP44, an AMPAR auxiliary protein that modulates desensitization of AMPAR currents, affects synaptic facilitation at retinogeniculate synapses and visually-evoked firing in awake mice.Xufeng ChenMuhammad AslamTim GollischKevin AllenJakob von EngelhardtNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xufeng Chen Muhammad Aslam Tim Gollisch Kevin Allen Jakob von Engelhardt CKAMP44 modulates integration of visual inputs in the lateral geniculate nucleus
description	The function of receptor desensitization in vivo is not well understood. Here, the authors show that deletion of CKAMP44, an AMPAR auxiliary protein that modulates desensitization of AMPAR currents, affects synaptic facilitation at retinogeniculate synapses and visually-evoked firing in awake mice.
format	article
author	Xufeng Chen Muhammad Aslam Tim Gollisch Kevin Allen Jakob von Engelhardt
author_facet	Xufeng Chen Muhammad Aslam Tim Gollisch Kevin Allen Jakob von Engelhardt
author_sort	Xufeng Chen
title	CKAMP44 modulates integration of visual inputs in the lateral geniculate nucleus
title_short	CKAMP44 modulates integration of visual inputs in the lateral geniculate nucleus
title_full	CKAMP44 modulates integration of visual inputs in the lateral geniculate nucleus
title_fullStr	CKAMP44 modulates integration of visual inputs in the lateral geniculate nucleus
title_full_unstemmed	CKAMP44 modulates integration of visual inputs in the lateral geniculate nucleus
title_sort	ckamp44 modulates integration of visual inputs in the lateral geniculate nucleus
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/993e2dfbe56d42b8b16b0d79d74bc768
work_keys_str_mv	AT xufengchen ckamp44modulatesintegrationofvisualinputsinthelateralgeniculatenucleus AT muhammadaslam ckamp44modulatesintegrationofvisualinputsinthelateralgeniculatenucleus AT timgollisch ckamp44modulatesintegrationofvisualinputsinthelateralgeniculatenucleus AT kevinallen ckamp44modulatesintegrationofvisualinputsinthelateralgeniculatenucleus AT jakobvonengelhardt ckamp44modulatesintegrationofvisualinputsinthelateralgeniculatenucleus
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CKAMP44 modulates integration of visual inputs in the lateral geniculate nucleus

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