Activation of a Ductal-to-Endocrine Transdifferentiation Transcriptional Program in the Pancreatic Cancer Cell Line PANC-1 Is Controlled by RAC1 and RAC1b through Antagonistic Regulation of Stemness Factors

Epithelial–mesenchymal transition (EMT) is a driving force for tumor growth, metastatic spread, therapy resistance, and the generation of cancer stem cells (CSCs). However, the regained stem cell character may also be exploited for therapeutic conversion of aggressive tumor cells to benign, highly d...

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Autores principales: Paula Marie Schmidtlein, Clara Volz, Alexander Hackel, Isabel Thürling, Darko Castven, Rüdiger Braun, Ulrich Friedrich Wellner, Björn Konukiewitz, Gabriela Riemekasten, Hendrik Lehnert, Jens-Uwe Marquardt, Hendrik Ungefroren
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
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Acceso en línea:https://doaj.org/article/9942266632504c8d88bf3c4bd7f07b0a
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