Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages

Organoid technology has enabled the generation of several breast cancer organoids. Here, the authors combine propagation of normal human mammary tissues with mass cytometry to evaluate the ability of organoid culture technologies to preserve stem cells and differentiated cell types.

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Autores principales:	Jennifer M. Rosenbluth, Ron C. J. Schackmann, G. Kenneth Gray, Laura M. Selfors, Carman Man-Chung Li, Mackenzie Boedicker, Hendrik J. Kuiken, Andrea Richardson, Jane Brock, Judy Garber, Deborah Dillon, Norman Sachs, Hans Clevers, Joan S. Brugge
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9943f96aecad444bafd945d3bf8d8389
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spelling	oai:doaj.org-article:9943f96aecad444bafd945d3bf8d83892021-12-02T17:32:13ZOrganoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages10.1038/s41467-020-15548-72041-1723https://doaj.org/article/9943f96aecad444bafd945d3bf8d83892020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15548-7https://doaj.org/toc/2041-1723Organoid technology has enabled the generation of several breast cancer organoids. Here, the authors combine propagation of normal human mammary tissues with mass cytometry to evaluate the ability of organoid culture technologies to preserve stem cells and differentiated cell types.Jennifer M. RosenbluthRon C. J. SchackmannG. Kenneth GrayLaura M. SelforsCarman Man-Chung LiMackenzie BoedickerHendrik J. KuikenAndrea RichardsonJane BrockJudy GarberDeborah DillonNorman SachsHans CleversJoan S. BruggeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jennifer M. Rosenbluth Ron C. J. Schackmann G. Kenneth Gray Laura M. Selfors Carman Man-Chung Li Mackenzie Boedicker Hendrik J. Kuiken Andrea Richardson Jane Brock Judy Garber Deborah Dillon Norman Sachs Hans Clevers Joan S. Brugge Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages
description	Organoid technology has enabled the generation of several breast cancer organoids. Here, the authors combine propagation of normal human mammary tissues with mass cytometry to evaluate the ability of organoid culture technologies to preserve stem cells and differentiated cell types.
format	article
author	Jennifer M. Rosenbluth Ron C. J. Schackmann G. Kenneth Gray Laura M. Selfors Carman Man-Chung Li Mackenzie Boedicker Hendrik J. Kuiken Andrea Richardson Jane Brock Judy Garber Deborah Dillon Norman Sachs Hans Clevers Joan S. Brugge
author_facet	Jennifer M. Rosenbluth Ron C. J. Schackmann G. Kenneth Gray Laura M. Selfors Carman Man-Chung Li Mackenzie Boedicker Hendrik J. Kuiken Andrea Richardson Jane Brock Judy Garber Deborah Dillon Norman Sachs Hans Clevers Joan S. Brugge
author_sort	Jennifer M. Rosenbluth
title	Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages
title_short	Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages
title_full	Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages
title_fullStr	Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages
title_full_unstemmed	Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages
title_sort	organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9943f96aecad444bafd945d3bf8d8389
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Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages

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