Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages

Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages

Organoid technology has enabled the generation of several breast cancer organoids. Here, the authors combine propagation of normal human mammary tissues with mass cytometry to evaluate the ability of organoid culture technologies to preserve stem cells and differentiated cell types.

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Bibliographic Details
Main Authors: Jennifer M. Rosenbluth, Ron C. J. Schackmann, G. Kenneth Gray, Laura M. Selfors, Carman Man-Chung Li, Mackenzie Boedicker, Hendrik J. Kuiken, Andrea Richardson, Jane Brock, Judy Garber, Deborah Dillon, Norman Sachs, Hans Clevers, Joan S. Brugge
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
Science
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Online Access:https://doaj.org/article/9943f96aecad444bafd945d3bf8d8389
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