An exported protein-interacting complex involved in the trafficking of virulence determinants in Plasmodium-infected erythrocytes

Plasmodium-infected red blood cells export virulence factors, such asPfEMP1, to the cell surface. Here, the authors identify a protein complex termed EPIC that interacts with PfEMP1 during export, and they show that knockdown of an EPIC component affects parasite virulence.

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Autores principales:	Steven Batinovic, Emma McHugh, Scott A. Chisholm, Kathryn Matthews, Boiyin Liu, Laure Dumont, Sarah C. Charnaud, Molly Parkyn Schneider, Paul R. Gilson, Tania F. de Koning-Ward, Matthew W. A. Dixon, Leann Tilley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9946bce78ad340cbacc3880e1452c735
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spelling	oai:doaj.org-article:9946bce78ad340cbacc3880e1452c7352021-12-02T14:42:34ZAn exported protein-interacting complex involved in the trafficking of virulence determinants in Plasmodium-infected erythrocytes10.1038/ncomms160442041-1723https://doaj.org/article/9946bce78ad340cbacc3880e1452c7352017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms16044https://doaj.org/toc/2041-1723Plasmodium-infected red blood cells export virulence factors, such asPfEMP1, to the cell surface. Here, the authors identify a protein complex termed EPIC that interacts with PfEMP1 during export, and they show that knockdown of an EPIC component affects parasite virulence.Steven BatinovicEmma McHughScott A. ChisholmKathryn MatthewsBoiyin LiuLaure DumontSarah C. CharnaudMolly Parkyn SchneiderPaul R. GilsonTania F. de Koning-WardMatthew W. A. DixonLeann TilleyNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Steven Batinovic Emma McHugh Scott A. Chisholm Kathryn Matthews Boiyin Liu Laure Dumont Sarah C. Charnaud Molly Parkyn Schneider Paul R. Gilson Tania F. de Koning-Ward Matthew W. A. Dixon Leann Tilley An exported protein-interacting complex involved in the trafficking of virulence determinants in Plasmodium-infected erythrocytes
description	Plasmodium-infected red blood cells export virulence factors, such asPfEMP1, to the cell surface. Here, the authors identify a protein complex termed EPIC that interacts with PfEMP1 during export, and they show that knockdown of an EPIC component affects parasite virulence.
format	article
author	Steven Batinovic Emma McHugh Scott A. Chisholm Kathryn Matthews Boiyin Liu Laure Dumont Sarah C. Charnaud Molly Parkyn Schneider Paul R. Gilson Tania F. de Koning-Ward Matthew W. A. Dixon Leann Tilley
author_facet	Steven Batinovic Emma McHugh Scott A. Chisholm Kathryn Matthews Boiyin Liu Laure Dumont Sarah C. Charnaud Molly Parkyn Schneider Paul R. Gilson Tania F. de Koning-Ward Matthew W. A. Dixon Leann Tilley
author_sort	Steven Batinovic
title	An exported protein-interacting complex involved in the trafficking of virulence determinants in Plasmodium-infected erythrocytes
title_short	An exported protein-interacting complex involved in the trafficking of virulence determinants in Plasmodium-infected erythrocytes
title_full	An exported protein-interacting complex involved in the trafficking of virulence determinants in Plasmodium-infected erythrocytes
title_fullStr	An exported protein-interacting complex involved in the trafficking of virulence determinants in Plasmodium-infected erythrocytes
title_full_unstemmed	An exported protein-interacting complex involved in the trafficking of virulence determinants in Plasmodium-infected erythrocytes
title_sort	exported protein-interacting complex involved in the trafficking of virulence determinants in plasmodium-infected erythrocytes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9946bce78ad340cbacc3880e1452c735
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An exported protein-interacting complex involved in the trafficking of virulence determinants in Plasmodium-infected erythrocytes

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