An exported protein-interacting complex involved in the trafficking of virulence determinants in Plasmodium-infected erythrocytes

An exported protein-interacting complex involved in the trafficking of virulence determinants in Plasmodium-infected erythrocytes

Plasmodium-infected red blood cells export virulence factors, such asPfEMP1, to the cell surface. Here, the authors identify a protein complex termed EPIC that interacts with PfEMP1 during export, and they show that knockdown of an EPIC component affects parasite virulence.

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Autores principales: Steven Batinovic, Emma McHugh, Scott A. Chisholm, Kathryn Matthews, Boiyin Liu, Laure Dumont, Sarah C. Charnaud, Molly Parkyn Schneider, Paul R. Gilson, Tania F. de Koning-Ward, Matthew W. A. Dixon, Leann Tilley
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/9946bce78ad340cbacc3880e1452c735
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