Analgesic effect of chronic oral administration of aerial part of Marrubium Vulgare in diabetic rats
BACKGROUND AND OBJECTIVE: Considering the antidiabetic and anti-inflammatory effect of marrubium vulgare (MV), this study was designed to investigate the analgesic effect of MV on formalin-induced nociceptive response (standard formalin test) in diabetic rats. METHODS: Forty-eight rats were randoml...
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Babol University of Medical Sciences
2006
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oai:doaj.org-article:9949981a847240e589d8f3191f2610302021-11-10T09:12:42ZAnalgesic effect of chronic oral administration of aerial part of Marrubium Vulgare in diabetic rats1561-41072251-7170https://doaj.org/article/9949981a847240e589d8f3191f2610302006-04-01T00:00:00Zhttp://jbums.org/article-1-2544-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Considering the antidiabetic and anti-inflammatory effect of marrubium vulgare (MV), this study was designed to investigate the analgesic effect of MV on formalin-induced nociceptive response (standard formalin test) in diabetic rats. METHODS: Forty-eight rats were randomly divided into control, MV-treated control, diabetic, sodium salicylate (SS)-treated diabetic, sodium salicylate (SS)-treated control and MV-treated diabetic groups. For induction of diabetes, streptozotocin was used at a single dose. The treatment groups received oral administration of MV-mixed pelleted food (6.25%) for two months. FINDINGS: In this study, administration of sodium salicylate to control and diabetic groups caused a significant reduction in pain score in the second phase of formalin test (p<0.05 and p<0.01, respectively). On the other hand, administration of marrubium vulgare for two months to control and diabetic groups caused a significant reduction in pain score at both phases of the formalin test (21.3% (p<0.05) and 18.4% reductions (p<0.05)) in control and diabetic groups (17.6% (p<0.05) and 17.9% reductions (p< 0.05)) as compared to untreated control and diabetic groups.CONCLUSION: The results indicate that administration of marrubium vulgare could attenuate nociceptive score in an experimental model of diabetes mellitus and this may be considered as a potential treatment for painful diabetic neuropathy.M Roghani,T Balouch Nejad MojaradBabol University of Medical Sciencesarticlemarrubium vulgarehyperalgesiadiabetes mellitusstreptozotocinratMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 8, Iss 2, Pp 7-13 (2006) |
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marrubium vulgare hyperalgesia diabetes mellitus streptozotocin rat Medicine R Medicine (General) R5-920 |
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marrubium vulgare hyperalgesia diabetes mellitus streptozotocin rat Medicine R Medicine (General) R5-920 M Roghani, T Balouch Nejad Mojarad Analgesic effect of chronic oral administration of aerial part of Marrubium Vulgare in diabetic rats |
| description |
BACKGROUND AND OBJECTIVE: Considering the antidiabetic and anti-inflammatory effect of marrubium vulgare (MV), this study was designed to investigate the analgesic effect of MV on formalin-induced nociceptive response (standard formalin test) in diabetic rats. METHODS: Forty-eight rats were randomly divided into control, MV-treated control, diabetic, sodium salicylate (SS)-treated diabetic, sodium salicylate (SS)-treated control and MV-treated diabetic groups. For induction of diabetes, streptozotocin was used at a single dose. The treatment groups received oral administration of MV-mixed pelleted food (6.25%) for two months. FINDINGS: In this study, administration of sodium salicylate to control and diabetic groups caused a significant reduction in pain score in the second phase of formalin test (p<0.05 and p<0.01, respectively). On the other hand, administration of marrubium vulgare for two months to control and diabetic groups caused a significant reduction in pain score at both phases of the formalin test (21.3% (p<0.05) and 18.4% reductions (p<0.05)) in control and diabetic groups (17.6% (p<0.05) and 17.9% reductions (p< 0.05)) as compared to untreated control and diabetic groups.CONCLUSION: The results indicate that administration of marrubium vulgare could attenuate nociceptive score in an experimental model of diabetes mellitus and this may be considered as a potential treatment for painful diabetic neuropathy. |
| format |
article |
| author |
M Roghani, T Balouch Nejad Mojarad |
| author_facet |
M Roghani, T Balouch Nejad Mojarad |
| author_sort |
M Roghani, |
| title |
Analgesic effect of chronic oral administration of aerial part of Marrubium Vulgare in diabetic rats |
| title_short |
Analgesic effect of chronic oral administration of aerial part of Marrubium Vulgare in diabetic rats |
| title_full |
Analgesic effect of chronic oral administration of aerial part of Marrubium Vulgare in diabetic rats |
| title_fullStr |
Analgesic effect of chronic oral administration of aerial part of Marrubium Vulgare in diabetic rats |
| title_full_unstemmed |
Analgesic effect of chronic oral administration of aerial part of Marrubium Vulgare in diabetic rats |
| title_sort |
analgesic effect of chronic oral administration of aerial part of marrubium vulgare in diabetic rats |
| publisher |
Babol University of Medical Sciences |
| publishDate |
2006 |
| url |
https://doaj.org/article/9949981a847240e589d8f3191f261030 |
| work_keys_str_mv |
AT mroghani analgesiceffectofchronicoraladministrationofaerialpartofmarrubiumvulgareindiabeticrats AT tbalouchnejadmojarad analgesiceffectofchronicoraladministrationofaerialpartofmarrubiumvulgareindiabeticrats |
| _version_ |
1718440218648903680 |