The Evolutionary Landscape of SARS-CoV-2 Variant B.1.1.519 and Its Clinical Impact in Mexico City
The SARS-CoV-2 pandemic is one of the most concerning health problems around the globe. We reported the emergence of SARS-CoV-2 variant B.1.1.519 in Mexico City. We reported the effective reproduction number (Rt) of B.1.1.519 and presented evidence of its geographical origin based on phylogenetic an...
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2021
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oai:doaj.org-article:994de52cbb26456d8f30fe994648e3b92021-11-25T19:13:08ZThe Evolutionary Landscape of SARS-CoV-2 Variant B.1.1.519 and Its Clinical Impact in Mexico City10.3390/v131121821999-4915https://doaj.org/article/994de52cbb26456d8f30fe994648e3b92021-10-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2182https://doaj.org/toc/1999-4915The SARS-CoV-2 pandemic is one of the most concerning health problems around the globe. We reported the emergence of SARS-CoV-2 variant B.1.1.519 in Mexico City. We reported the effective reproduction number (Rt) of B.1.1.519 and presented evidence of its geographical origin based on phylogenetic analysis. We also studied its evolution via haplotype analysis and identified the most recurrent haplotypes. Finally, we studied the clinical impact of B.1.1.519. The B.1.1.519 variant was predominant between November 2020 and May 2021, reaching 90% of all cases sequenced in February 2021. It is characterized by three amino acid changes in the spike protein: T478K, P681H, and T732A. Its Rt varies between 0.5 and 2.9. Its geographical origin remain to be investigated. Patients infected with variant B.1.1.519 showed a highly significant adjusted odds ratio (aOR) increase of 1.85 over non-B.1.1.519 patients for developing a severe/critical outcome (<i>p</i> = 0.000296, 1.33–2.6 95% CI) and a 2.35-fold increase for hospitalization (<i>p</i> = 0.005, 1.32–4.34 95% CI). The continuous monitoring of this and other variants will be required to control the ongoing pandemic as it evolves.Alberto Cedro-TandaLaura Gómez-RomeroNicolás AlcarazGuillermo de Anda-JaureguiFernando PeñalozaBernardo MorenoMarco A. Escobar-ArrazolaOscar A. Ramirez-VegaPaulina Munguia-GarzaFrancisco Garcia-CardenasMireya Cisneros-VillanuevaJose L. Moreno-CamachoJorge Rodriguez-GallegosMarco A. Luna-Ruiz EsparzaMiguel A. Fernández RojasAlfredo Mendoza-VargasJuan Pablo Reyes-GrajedaAbraham Campos-RomeroOfelia AnguloRosaura RuizClaudia Sheinbaum-PardoJosé Sifuentes-OsornioDavid KershenobichAlfredo Hidalgo-MirandaLuis A. HerreraMDPI AGarticleSARS-CoV-2B.1.1.519 varianteffective reproduction numberphylogenetic analysishaplotype analysisclinical impactMicrobiologyQR1-502ENViruses, Vol 13, Iss 2182, p 2182 (2021) |
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DOAJ |
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SARS-CoV-2 B.1.1.519 variant effective reproduction number phylogenetic analysis haplotype analysis clinical impact Microbiology QR1-502 |
| spellingShingle |
SARS-CoV-2 B.1.1.519 variant effective reproduction number phylogenetic analysis haplotype analysis clinical impact Microbiology QR1-502 Alberto Cedro-Tanda Laura Gómez-Romero Nicolás Alcaraz Guillermo de Anda-Jauregui Fernando Peñaloza Bernardo Moreno Marco A. Escobar-Arrazola Oscar A. Ramirez-Vega Paulina Munguia-Garza Francisco Garcia-Cardenas Mireya Cisneros-Villanueva Jose L. Moreno-Camacho Jorge Rodriguez-Gallegos Marco A. Luna-Ruiz Esparza Miguel A. Fernández Rojas Alfredo Mendoza-Vargas Juan Pablo Reyes-Grajeda Abraham Campos-Romero Ofelia Angulo Rosaura Ruiz Claudia Sheinbaum-Pardo José Sifuentes-Osornio David Kershenobich Alfredo Hidalgo-Miranda Luis A. Herrera The Evolutionary Landscape of SARS-CoV-2 Variant B.1.1.519 and Its Clinical Impact in Mexico City |
| description |
The SARS-CoV-2 pandemic is one of the most concerning health problems around the globe. We reported the emergence of SARS-CoV-2 variant B.1.1.519 in Mexico City. We reported the effective reproduction number (Rt) of B.1.1.519 and presented evidence of its geographical origin based on phylogenetic analysis. We also studied its evolution via haplotype analysis and identified the most recurrent haplotypes. Finally, we studied the clinical impact of B.1.1.519. The B.1.1.519 variant was predominant between November 2020 and May 2021, reaching 90% of all cases sequenced in February 2021. It is characterized by three amino acid changes in the spike protein: T478K, P681H, and T732A. Its Rt varies between 0.5 and 2.9. Its geographical origin remain to be investigated. Patients infected with variant B.1.1.519 showed a highly significant adjusted odds ratio (aOR) increase of 1.85 over non-B.1.1.519 patients for developing a severe/critical outcome (<i>p</i> = 0.000296, 1.33–2.6 95% CI) and a 2.35-fold increase for hospitalization (<i>p</i> = 0.005, 1.32–4.34 95% CI). The continuous monitoring of this and other variants will be required to control the ongoing pandemic as it evolves. |
| format |
article |
| author |
Alberto Cedro-Tanda Laura Gómez-Romero Nicolás Alcaraz Guillermo de Anda-Jauregui Fernando Peñaloza Bernardo Moreno Marco A. Escobar-Arrazola Oscar A. Ramirez-Vega Paulina Munguia-Garza Francisco Garcia-Cardenas Mireya Cisneros-Villanueva Jose L. Moreno-Camacho Jorge Rodriguez-Gallegos Marco A. Luna-Ruiz Esparza Miguel A. Fernández Rojas Alfredo Mendoza-Vargas Juan Pablo Reyes-Grajeda Abraham Campos-Romero Ofelia Angulo Rosaura Ruiz Claudia Sheinbaum-Pardo José Sifuentes-Osornio David Kershenobich Alfredo Hidalgo-Miranda Luis A. Herrera |
| author_facet |
Alberto Cedro-Tanda Laura Gómez-Romero Nicolás Alcaraz Guillermo de Anda-Jauregui Fernando Peñaloza Bernardo Moreno Marco A. Escobar-Arrazola Oscar A. Ramirez-Vega Paulina Munguia-Garza Francisco Garcia-Cardenas Mireya Cisneros-Villanueva Jose L. Moreno-Camacho Jorge Rodriguez-Gallegos Marco A. Luna-Ruiz Esparza Miguel A. Fernández Rojas Alfredo Mendoza-Vargas Juan Pablo Reyes-Grajeda Abraham Campos-Romero Ofelia Angulo Rosaura Ruiz Claudia Sheinbaum-Pardo José Sifuentes-Osornio David Kershenobich Alfredo Hidalgo-Miranda Luis A. Herrera |
| author_sort |
Alberto Cedro-Tanda |
| title |
The Evolutionary Landscape of SARS-CoV-2 Variant B.1.1.519 and Its Clinical Impact in Mexico City |
| title_short |
The Evolutionary Landscape of SARS-CoV-2 Variant B.1.1.519 and Its Clinical Impact in Mexico City |
| title_full |
The Evolutionary Landscape of SARS-CoV-2 Variant B.1.1.519 and Its Clinical Impact in Mexico City |
| title_fullStr |
The Evolutionary Landscape of SARS-CoV-2 Variant B.1.1.519 and Its Clinical Impact in Mexico City |
| title_full_unstemmed |
The Evolutionary Landscape of SARS-CoV-2 Variant B.1.1.519 and Its Clinical Impact in Mexico City |
| title_sort |
evolutionary landscape of sars-cov-2 variant b.1.1.519 and its clinical impact in mexico city |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/994de52cbb26456d8f30fe994648e3b9 |
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