Pneumococci in the African meningitis belt: meningitis incidence and carriage prevalence in children and adults.
<h4>Background</h4>The development of optimal vaccination strategies for pneumococcal conjugate vaccines requires serotype-specific data on disease incidence and carriage prevalence. This information is lacking for the African meningitis belt.<h4>Methods</h4>We conducted hosp...
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2012
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oai:doaj.org-article:994f55c58a594197b86550c08325285c2021-11-18T08:04:09ZPneumococci in the African meningitis belt: meningitis incidence and carriage prevalence in children and adults.1932-620310.1371/journal.pone.0052464https://doaj.org/article/994f55c58a594197b86550c08325285c2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23285051/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The development of optimal vaccination strategies for pneumococcal conjugate vaccines requires serotype-specific data on disease incidence and carriage prevalence. This information is lacking for the African meningitis belt.<h4>Methods</h4>We conducted hospital-based surveillance of acute bacterial meningitis in an urban and rural population of Burkina Faso during 2007-09. Cerebrospinal fluid was evaluated by polymerase chain reaction for species and serotype. In 2008, nasopharyngeal swabs were obtained from a representative population sample (1 month to 39 years; N = 519) and additional oropharyngeal swabs from 145 participants. Swabs were evaluated by culture.<h4>Results</h4>Annual pneumococcal meningitis incidence rates were highest among <6-month-old (58/100,000) and 15- to 19-year-old persons (15/100,000). Annual serotype 1 incidence was around 5/100,000 in all age groups. Pneumococcal carriage prevalence in nasopharyngeal swabs was 63% among <5-year-old children and 22% among ≥5-year-old persons, but adding oropharyngeal to nasopharyngeal swabs increased the estimated carriage prevalence by 60%. Serotype 1 showed high propensity for invasive disease, particularly among persons aged ≥5 years.<h4>Conclusions</h4>Serotype 1 causes the majority of cases with a relatively constant age-specific incidence. Pneumococcal carriage is common in all age groups including adults. Vaccination programs in this region may need to include older target age groups for optimal impact on disease burden.Judith E MuellerSeydou YaroMacaire S OuédraogoNatalia LevinaBerthe-Marie Njanpop-LafourcadeHaoua TallRégina S IdohouOumarou SanouSita S KromanAly DraboBoubacar NacroAthanase MillogoMark van der LindenBradford D GessnerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e52464 (2012) |
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Medicine R Science Q Judith E Mueller Seydou Yaro Macaire S Ouédraogo Natalia Levina Berthe-Marie Njanpop-Lafourcade Haoua Tall Régina S Idohou Oumarou Sanou Sita S Kroman Aly Drabo Boubacar Nacro Athanase Millogo Mark van der Linden Bradford D Gessner Pneumococci in the African meningitis belt: meningitis incidence and carriage prevalence in children and adults. |
| description |
<h4>Background</h4>The development of optimal vaccination strategies for pneumococcal conjugate vaccines requires serotype-specific data on disease incidence and carriage prevalence. This information is lacking for the African meningitis belt.<h4>Methods</h4>We conducted hospital-based surveillance of acute bacterial meningitis in an urban and rural population of Burkina Faso during 2007-09. Cerebrospinal fluid was evaluated by polymerase chain reaction for species and serotype. In 2008, nasopharyngeal swabs were obtained from a representative population sample (1 month to 39 years; N = 519) and additional oropharyngeal swabs from 145 participants. Swabs were evaluated by culture.<h4>Results</h4>Annual pneumococcal meningitis incidence rates were highest among <6-month-old (58/100,000) and 15- to 19-year-old persons (15/100,000). Annual serotype 1 incidence was around 5/100,000 in all age groups. Pneumococcal carriage prevalence in nasopharyngeal swabs was 63% among <5-year-old children and 22% among ≥5-year-old persons, but adding oropharyngeal to nasopharyngeal swabs increased the estimated carriage prevalence by 60%. Serotype 1 showed high propensity for invasive disease, particularly among persons aged ≥5 years.<h4>Conclusions</h4>Serotype 1 causes the majority of cases with a relatively constant age-specific incidence. Pneumococcal carriage is common in all age groups including adults. Vaccination programs in this region may need to include older target age groups for optimal impact on disease burden. |
| format |
article |
| author |
Judith E Mueller Seydou Yaro Macaire S Ouédraogo Natalia Levina Berthe-Marie Njanpop-Lafourcade Haoua Tall Régina S Idohou Oumarou Sanou Sita S Kroman Aly Drabo Boubacar Nacro Athanase Millogo Mark van der Linden Bradford D Gessner |
| author_facet |
Judith E Mueller Seydou Yaro Macaire S Ouédraogo Natalia Levina Berthe-Marie Njanpop-Lafourcade Haoua Tall Régina S Idohou Oumarou Sanou Sita S Kroman Aly Drabo Boubacar Nacro Athanase Millogo Mark van der Linden Bradford D Gessner |
| author_sort |
Judith E Mueller |
| title |
Pneumococci in the African meningitis belt: meningitis incidence and carriage prevalence in children and adults. |
| title_short |
Pneumococci in the African meningitis belt: meningitis incidence and carriage prevalence in children and adults. |
| title_full |
Pneumococci in the African meningitis belt: meningitis incidence and carriage prevalence in children and adults. |
| title_fullStr |
Pneumococci in the African meningitis belt: meningitis incidence and carriage prevalence in children and adults. |
| title_full_unstemmed |
Pneumococci in the African meningitis belt: meningitis incidence and carriage prevalence in children and adults. |
| title_sort |
pneumococci in the african meningitis belt: meningitis incidence and carriage prevalence in children and adults. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/994f55c58a594197b86550c08325285c |
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