Glycyrol Alone or in Combination with Gefitinib Is Effective against Gefitinib-Resistant HCC827GR Lung Cancer Cells

Gefitinib has been clinically demonstrated to be effective in the first-line setting for patients with advanced EGFR-mutated non-small cell lung cancer (NSCLC). However, acquired therapeutic resistance to gefitinib almost unavoidably develops, posing a major hurdle for its clinical utilization. Our...

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Autores principales:	Shuang Zhao, Shangyun Lu, Lihong Fan, Hongbo Hu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	glycyrol gefitinib resistance HCC827GR cells MET Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/995147e5094d43f6a01c503eaef9b251
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spelling	oai:doaj.org-article:995147e5094d43f6a01c503eaef9b2512021-11-25T16:30:46ZGlycyrol Alone or in Combination with Gefitinib Is Effective against Gefitinib-Resistant HCC827GR Lung Cancer Cells10.3390/app1122105262076-3417https://doaj.org/article/995147e5094d43f6a01c503eaef9b2512021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/22/10526https://doaj.org/toc/2076-3417Gefitinib has been clinically demonstrated to be effective in the first-line setting for patients with advanced EGFR-mutated non-small cell lung cancer (NSCLC). However, acquired therapeutic resistance to gefitinib almost unavoidably develops, posing a major hurdle for its clinical utilization. Our previous study showed that glycyrol (GC), a representative of coumarin compounds isolated from the medicinal plant licorice, was effective against A549 lung cancer cells in both cell culture and a murine xenograft model. In this follow-up study, we evaluated the effect of glycyrol against gefitinib-resistant NSCLC and its ability to overcome the resistance using gefitinib-resistant HCC827GR cells. Results showed that glycyrol was effective against HCC827GR cells in both in vitro and in vivo. Moreover, glycyrol was able to significantly increase the sensitivity of HCC827GR cells to gefitinib, mechanistically associated with inactivating MET, which is a known important contributor to the resistance of HCC827GR cells to gefitinib. The findings of the present study suggest that glycyrol holds potential to be developed as a novel agent against gefitinib-resistant NSCLC.Shuang ZhaoShangyun LuLihong FanHongbo HuMDPI AGarticleglycyrolgefitinibresistanceHCC827GR cellsMETTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 10526, p 10526 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	glycyrol gefitinib resistance HCC827GR cells MET Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	glycyrol gefitinib resistance HCC827GR cells MET Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Shuang Zhao Shangyun Lu Lihong Fan Hongbo Hu Glycyrol Alone or in Combination with Gefitinib Is Effective against Gefitinib-Resistant HCC827GR Lung Cancer Cells
description	Gefitinib has been clinically demonstrated to be effective in the first-line setting for patients with advanced EGFR-mutated non-small cell lung cancer (NSCLC). However, acquired therapeutic resistance to gefitinib almost unavoidably develops, posing a major hurdle for its clinical utilization. Our previous study showed that glycyrol (GC), a representative of coumarin compounds isolated from the medicinal plant licorice, was effective against A549 lung cancer cells in both cell culture and a murine xenograft model. In this follow-up study, we evaluated the effect of glycyrol against gefitinib-resistant NSCLC and its ability to overcome the resistance using gefitinib-resistant HCC827GR cells. Results showed that glycyrol was effective against HCC827GR cells in both in vitro and in vivo. Moreover, glycyrol was able to significantly increase the sensitivity of HCC827GR cells to gefitinib, mechanistically associated with inactivating MET, which is a known important contributor to the resistance of HCC827GR cells to gefitinib. The findings of the present study suggest that glycyrol holds potential to be developed as a novel agent against gefitinib-resistant NSCLC.
format	article
author	Shuang Zhao Shangyun Lu Lihong Fan Hongbo Hu
author_facet	Shuang Zhao Shangyun Lu Lihong Fan Hongbo Hu
author_sort	Shuang Zhao
title	Glycyrol Alone or in Combination with Gefitinib Is Effective against Gefitinib-Resistant HCC827GR Lung Cancer Cells
title_short	Glycyrol Alone or in Combination with Gefitinib Is Effective against Gefitinib-Resistant HCC827GR Lung Cancer Cells
title_full	Glycyrol Alone or in Combination with Gefitinib Is Effective against Gefitinib-Resistant HCC827GR Lung Cancer Cells
title_fullStr	Glycyrol Alone or in Combination with Gefitinib Is Effective against Gefitinib-Resistant HCC827GR Lung Cancer Cells
title_full_unstemmed	Glycyrol Alone or in Combination with Gefitinib Is Effective against Gefitinib-Resistant HCC827GR Lung Cancer Cells
title_sort	glycyrol alone or in combination with gefitinib is effective against gefitinib-resistant hcc827gr lung cancer cells
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/995147e5094d43f6a01c503eaef9b251
work_keys_str_mv	AT shuangzhao glycyrolaloneorincombinationwithgefitinibiseffectiveagainstgefitinibresistanthcc827grlungcancercells AT shangyunlu glycyrolaloneorincombinationwithgefitinibiseffectiveagainstgefitinibresistanthcc827grlungcancercells AT lihongfan glycyrolaloneorincombinationwithgefitinibiseffectiveagainstgefitinibresistanthcc827grlungcancercells AT hongbohu glycyrolaloneorincombinationwithgefitinibiseffectiveagainstgefitinibresistanthcc827grlungcancercells
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Glycyrol Alone or in Combination with Gefitinib Is Effective against Gefitinib-Resistant HCC827GR Lung Cancer Cells

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