Broad genic repression domains signify enhanced silencing of oncogenes

Epigenetically altered genes can have a key role in cancer pathobiology but epigenetic signatures that distinguish oncogenes are not yet known. Here, the authors identify broad genic repression domains, defined by widespread H3K27me3 modification, as an epigenetic signature to provide mutation-indep...

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Autores principales:	Dongyu Zhao, Lili Zhang, Min Zhang, Bo Xia, Jie Lv, Xinlei Gao, Guangyu Wang, Qingshu Meng, Yang Yi, Sen Zhu, Alin S. Tomoiaga, Min Gyu Lee, John P. Cooke, Qi Cao, Kaifu Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/99556b9d90014cfca66fa8bae7631c36
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spelling	oai:doaj.org-article:99556b9d90014cfca66fa8bae7631c362021-12-02T17:32:26ZBroad genic repression domains signify enhanced silencing of oncogenes10.1038/s41467-020-18913-82041-1723https://doaj.org/article/99556b9d90014cfca66fa8bae7631c362020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18913-8https://doaj.org/toc/2041-1723Epigenetically altered genes can have a key role in cancer pathobiology but epigenetic signatures that distinguish oncogenes are not yet known. Here, the authors identify broad genic repression domains, defined by widespread H3K27me3 modification, as an epigenetic signature to provide mutation-independent information for discovery of potential oncogenes.Dongyu ZhaoLili ZhangMin ZhangBo XiaJie LvXinlei GaoGuangyu WangQingshu MengYang YiSen ZhuAlin S. TomoiagaMin Gyu LeeJohn P. CookeQi CaoKaifu ChenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dongyu Zhao Lili Zhang Min Zhang Bo Xia Jie Lv Xinlei Gao Guangyu Wang Qingshu Meng Yang Yi Sen Zhu Alin S. Tomoiaga Min Gyu Lee John P. Cooke Qi Cao Kaifu Chen Broad genic repression domains signify enhanced silencing of oncogenes
description	Epigenetically altered genes can have a key role in cancer pathobiology but epigenetic signatures that distinguish oncogenes are not yet known. Here, the authors identify broad genic repression domains, defined by widespread H3K27me3 modification, as an epigenetic signature to provide mutation-independent information for discovery of potential oncogenes.
format	article
author	Dongyu Zhao Lili Zhang Min Zhang Bo Xia Jie Lv Xinlei Gao Guangyu Wang Qingshu Meng Yang Yi Sen Zhu Alin S. Tomoiaga Min Gyu Lee John P. Cooke Qi Cao Kaifu Chen
author_facet	Dongyu Zhao Lili Zhang Min Zhang Bo Xia Jie Lv Xinlei Gao Guangyu Wang Qingshu Meng Yang Yi Sen Zhu Alin S. Tomoiaga Min Gyu Lee John P. Cooke Qi Cao Kaifu Chen
author_sort	Dongyu Zhao
title	Broad genic repression domains signify enhanced silencing of oncogenes
title_short	Broad genic repression domains signify enhanced silencing of oncogenes
title_full	Broad genic repression domains signify enhanced silencing of oncogenes
title_fullStr	Broad genic repression domains signify enhanced silencing of oncogenes
title_full_unstemmed	Broad genic repression domains signify enhanced silencing of oncogenes
title_sort	broad genic repression domains signify enhanced silencing of oncogenes
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/99556b9d90014cfca66fa8bae7631c36
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Broad genic repression domains signify enhanced silencing of oncogenes

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