Broad genic repression domains signify enhanced silencing of oncogenes

Epigenetically altered genes can have a key role in cancer pathobiology but epigenetic signatures that distinguish oncogenes are not yet known. Here, the authors identify broad genic repression domains, defined by widespread H3K27me3 modification, as an epigenetic signature to provide mutation-indep...

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Bibliographic Details
Main Authors: Dongyu Zhao, Lili Zhang, Min Zhang, Bo Xia, Jie Lv, Xinlei Gao, Guangyu Wang, Qingshu Meng, Yang Yi, Sen Zhu, Alin S. Tomoiaga, Min Gyu Lee, John P. Cooke, Qi Cao, Kaifu Chen
Format: article
Language:EN
Published: Nature Portfolio 2020
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Online Access:https://doaj.org/article/99556b9d90014cfca66fa8bae7631c36
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