Risk-factors for re-admission and outcome of patients hospitalized with confirmed COVID-19

Abstract Burden of COVID-19 on Hospitals across the globe is enormous and has clinical and economic implications. In this retrospective study including consecutive adult patients with confirmed SARS-CoV-2 who were admitted between 3/2020 and 30/9/20, we aimed to identify post-discharge outcomes and...

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Autores principales:	Hefziba Green, Dafna Yahav, Noa Eliakim-Raz, Nitzan Karny-Epstein, Shiri Kushnir, Tzippy Shochat, Boaz Tadmor, Alon Grossman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9956b8f34f9646619762a28c868112bf
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spelling	oai:doaj.org-article:9956b8f34f9646619762a28c868112bf2021-12-02T16:38:49ZRisk-factors for re-admission and outcome of patients hospitalized with confirmed COVID-1910.1038/s41598-021-96716-72045-2322https://doaj.org/article/9956b8f34f9646619762a28c868112bf2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96716-7https://doaj.org/toc/2045-2322Abstract Burden of COVID-19 on Hospitals across the globe is enormous and has clinical and economic implications. In this retrospective study including consecutive adult patients with confirmed SARS-CoV-2 who were admitted between 3/2020 and 30/9/20, we aimed to identify post-discharge outcomes and risk factors for re-admission among COVID-19 hospitalized patients. Mortality and re-admissions were documented for a median post discharge follow up of 59 days (interquartile range 28,161). Univariate and multivariate analyses of risk factors for re-admission were performed. Overall, 618 hospitalized COVID-19 patients were included. Of the 544 patient who were discharged, 10 patients (1.83%) died following discharge and 50 patients (9.2%) were re-admitted. Median time to re-admission was 7 days (interquartile range 3, 24). Oxygen saturation or treatment prior to discharge were not associated with re-admissions. Risk factors for re-admission in multivariate analysis included solid organ transplantation (hazard ratio [HR] 3.37, 95% confidence interval [CI] 2.73–7.5, p = 0.0028) and higher Charlson comorbidity index (HR 1.34, 95% CI 1.23–1.46, p < 0.0001). Mean age of post discharge mortality cases was 85.0 (SD 9.98), 80% of them had cognitive decline or needed help in ADL at baseline. In conclusion, re-admission rates of hospitalized COVID-19 are fairly moderate. Predictors of re-admission are non-modifiable, including baseline comorbidities, rather than COVID-19 severity or treatment.Hefziba GreenDafna YahavNoa Eliakim-RazNitzan Karny-EpsteinShiri KushnirTzippy ShochatBoaz TadmorAlon GrossmanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hefziba Green Dafna Yahav Noa Eliakim-Raz Nitzan Karny-Epstein Shiri Kushnir Tzippy Shochat Boaz Tadmor Alon Grossman Risk-factors for re-admission and outcome of patients hospitalized with confirmed COVID-19
description	Abstract Burden of COVID-19 on Hospitals across the globe is enormous and has clinical and economic implications. In this retrospective study including consecutive adult patients with confirmed SARS-CoV-2 who were admitted between 3/2020 and 30/9/20, we aimed to identify post-discharge outcomes and risk factors for re-admission among COVID-19 hospitalized patients. Mortality and re-admissions were documented for a median post discharge follow up of 59 days (interquartile range 28,161). Univariate and multivariate analyses of risk factors for re-admission were performed. Overall, 618 hospitalized COVID-19 patients were included. Of the 544 patient who were discharged, 10 patients (1.83%) died following discharge and 50 patients (9.2%) were re-admitted. Median time to re-admission was 7 days (interquartile range 3, 24). Oxygen saturation or treatment prior to discharge were not associated with re-admissions. Risk factors for re-admission in multivariate analysis included solid organ transplantation (hazard ratio [HR] 3.37, 95% confidence interval [CI] 2.73–7.5, p = 0.0028) and higher Charlson comorbidity index (HR 1.34, 95% CI 1.23–1.46, p < 0.0001). Mean age of post discharge mortality cases was 85.0 (SD 9.98), 80% of them had cognitive decline or needed help in ADL at baseline. In conclusion, re-admission rates of hospitalized COVID-19 are fairly moderate. Predictors of re-admission are non-modifiable, including baseline comorbidities, rather than COVID-19 severity or treatment.
format	article
author	Hefziba Green Dafna Yahav Noa Eliakim-Raz Nitzan Karny-Epstein Shiri Kushnir Tzippy Shochat Boaz Tadmor Alon Grossman
author_facet	Hefziba Green Dafna Yahav Noa Eliakim-Raz Nitzan Karny-Epstein Shiri Kushnir Tzippy Shochat Boaz Tadmor Alon Grossman
author_sort	Hefziba Green
title	Risk-factors for re-admission and outcome of patients hospitalized with confirmed COVID-19
title_short	Risk-factors for re-admission and outcome of patients hospitalized with confirmed COVID-19
title_full	Risk-factors for re-admission and outcome of patients hospitalized with confirmed COVID-19
title_fullStr	Risk-factors for re-admission and outcome of patients hospitalized with confirmed COVID-19
title_full_unstemmed	Risk-factors for re-admission and outcome of patients hospitalized with confirmed COVID-19
title_sort	risk-factors for re-admission and outcome of patients hospitalized with confirmed covid-19
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9956b8f34f9646619762a28c868112bf
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Risk-factors for re-admission and outcome of patients hospitalized with confirmed COVID-19

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