A correlational study of Weifuchun and its clinical effect on intestinal flora in precancerous lesions of gastric cancer

Abstract Background Weifuchun (WFC), a Chinese herbal prescription consisting of Red Ginseng, Isodon amethystoides and Fructus Aurantii, is commonly used in China to treat a variety of chronic stomach disorders. The aim of the paper was to determine the effect of WFC on intestinal microbiota changes...

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Autores principales:	Yanqin Bian, Xi Chen, Hongyan Cao, Dong Xie, Meiping Zhu, Nong Yuan, Lu Lu, Bingjie Lu, Chao Wu, Nisma Lena Bahaji Azami, Zheng Wang, Huijun Wang, Yeqing Zhang, Kun Li, Guan Ye, Mingyu Sun
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Precancerous lesions of gastric cancer Intestinal microbiota Weifuchun Randomized controlled clinical trial Other systems of medicine RZ201-999
Acceso en línea:	https://doaj.org/article/9956f3035e14469c98c681326c2e1897
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spelling	oai:doaj.org-article:9956f3035e14469c98c681326c2e18972021-11-21T12:06:47ZA correlational study of Weifuchun and its clinical effect on intestinal flora in precancerous lesions of gastric cancer10.1186/s13020-021-00529-91749-8546https://doaj.org/article/9956f3035e14469c98c681326c2e18972021-11-01T00:00:00Zhttps://doi.org/10.1186/s13020-021-00529-9https://doaj.org/toc/1749-8546Abstract Background Weifuchun (WFC), a Chinese herbal prescription consisting of Red Ginseng, Isodon amethystoides and Fructus Aurantii, is commonly used in China to treat a variety of chronic stomach disorders. The aim of the paper was to determine the effect of WFC on intestinal microbiota changes in precancerous lesions of gastric cancer (PLGC) patients. Methods PLGC patients of H. pylori negative were randomly divided into two groups and received either WFC tablets for a dose of 1.44 g three times a day or vitacoenzyme (Vit) tablets for a dose of 0.8 g three times a day. All patients were treated for 6 months consecutively. Gastroscopy and histopathology were used to assess the histopathological changes in gastric tissues before and after treatment. 16S rRNA gene sequencing was carried out to assess the effects WFC on intestinal microbiota changes in PLGC patients. Receiver Operating Characteristics (ROC) analysis was used to assess the sensitivity and specificity of different intestinal microbiota in distinguishing between PLGC patients and healthy control group. Results Gastroscopy and histopathological results indicated that WFC could improve the pathological condition of PLGC patients, especially in the case of atrophy or intestinal metaplasia. The results of 16S rRNA gene sequencing indicated that WFC could regulate microbial diversity, microbial composition, and abundance of the intestinal microbiota of PLGC patients. Following WFC treatment, the relative abundance of Parabacteroides decreased in WFC group when compared with the Vit group. ROC analysis found that the Parabacteroides could effectively distinguish PLGC patients from healthy individuals with sensitivity of 0.79 and specificity of 0.8. Conclusions WFC could slow down the progression of PLGC by regulating intestinal microbiota abundance. Trial registration NCT03814629. Name of registry: Randomized Clinical Trial: Weifuchun Treatment on Precancerous Lesions of Gastric Cancer. Registered 3 August 2018-Retrospectively registered, https://register.clinicaltrials.gov/ NCT03814629.Yanqin BianXi ChenHongyan CaoDong XieMeiping ZhuNong YuanLu LuBingjie LuChao WuNisma Lena Bahaji AzamiZheng WangHuijun WangYeqing ZhangKun LiGuan YeMingyu SunBMCarticlePrecancerous lesions of gastric cancerIntestinal microbiotaWeifuchunRandomized controlled clinical trialOther systems of medicineRZ201-999ENChinese Medicine, Vol 16, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Precancerous lesions of gastric cancer Intestinal microbiota Weifuchun Randomized controlled clinical trial Other systems of medicine RZ201-999
spellingShingle	Precancerous lesions of gastric cancer Intestinal microbiota Weifuchun Randomized controlled clinical trial Other systems of medicine RZ201-999 Yanqin Bian Xi Chen Hongyan Cao Dong Xie Meiping Zhu Nong Yuan Lu Lu Bingjie Lu Chao Wu Nisma Lena Bahaji Azami Zheng Wang Huijun Wang Yeqing Zhang Kun Li Guan Ye Mingyu Sun A correlational study of Weifuchun and its clinical effect on intestinal flora in precancerous lesions of gastric cancer
description	Abstract Background Weifuchun (WFC), a Chinese herbal prescription consisting of Red Ginseng, Isodon amethystoides and Fructus Aurantii, is commonly used in China to treat a variety of chronic stomach disorders. The aim of the paper was to determine the effect of WFC on intestinal microbiota changes in precancerous lesions of gastric cancer (PLGC) patients. Methods PLGC patients of H. pylori negative were randomly divided into two groups and received either WFC tablets for a dose of 1.44 g three times a day or vitacoenzyme (Vit) tablets for a dose of 0.8 g three times a day. All patients were treated for 6 months consecutively. Gastroscopy and histopathology were used to assess the histopathological changes in gastric tissues before and after treatment. 16S rRNA gene sequencing was carried out to assess the effects WFC on intestinal microbiota changes in PLGC patients. Receiver Operating Characteristics (ROC) analysis was used to assess the sensitivity and specificity of different intestinal microbiota in distinguishing between PLGC patients and healthy control group. Results Gastroscopy and histopathological results indicated that WFC could improve the pathological condition of PLGC patients, especially in the case of atrophy or intestinal metaplasia. The results of 16S rRNA gene sequencing indicated that WFC could regulate microbial diversity, microbial composition, and abundance of the intestinal microbiota of PLGC patients. Following WFC treatment, the relative abundance of Parabacteroides decreased in WFC group when compared with the Vit group. ROC analysis found that the Parabacteroides could effectively distinguish PLGC patients from healthy individuals with sensitivity of 0.79 and specificity of 0.8. Conclusions WFC could slow down the progression of PLGC by regulating intestinal microbiota abundance. Trial registration NCT03814629. Name of registry: Randomized Clinical Trial: Weifuchun Treatment on Precancerous Lesions of Gastric Cancer. Registered 3 August 2018-Retrospectively registered, https://register.clinicaltrials.gov/ NCT03814629.
format	article
author	Yanqin Bian Xi Chen Hongyan Cao Dong Xie Meiping Zhu Nong Yuan Lu Lu Bingjie Lu Chao Wu Nisma Lena Bahaji Azami Zheng Wang Huijun Wang Yeqing Zhang Kun Li Guan Ye Mingyu Sun
author_facet	Yanqin Bian Xi Chen Hongyan Cao Dong Xie Meiping Zhu Nong Yuan Lu Lu Bingjie Lu Chao Wu Nisma Lena Bahaji Azami Zheng Wang Huijun Wang Yeqing Zhang Kun Li Guan Ye Mingyu Sun
author_sort	Yanqin Bian
title	A correlational study of Weifuchun and its clinical effect on intestinal flora in precancerous lesions of gastric cancer
title_short	A correlational study of Weifuchun and its clinical effect on intestinal flora in precancerous lesions of gastric cancer
title_full	A correlational study of Weifuchun and its clinical effect on intestinal flora in precancerous lesions of gastric cancer
title_fullStr	A correlational study of Weifuchun and its clinical effect on intestinal flora in precancerous lesions of gastric cancer
title_full_unstemmed	A correlational study of Weifuchun and its clinical effect on intestinal flora in precancerous lesions of gastric cancer
title_sort	correlational study of weifuchun and its clinical effect on intestinal flora in precancerous lesions of gastric cancer
publisher	BMC
publishDate	2021
url	https://doaj.org/article/9956f3035e14469c98c681326c2e1897
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A correlational study of Weifuchun and its clinical effect on intestinal flora in precancerous lesions of gastric cancer

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