JNK regulates muscle remodeling via myostatin/SMAD inhibition

Endurance and resistance exercise have different effects on skeletal muscle phenotype. Using mouse models and human subjects, the authors show that JNK/Smad2 signaling acts as molecular switch that when activated by resistance exercise leads to hypertrophy, and when inhibited promotes endurance adap...

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Autores principales:	Sarah J. Lessard, Tara L. MacDonald, Prerana Pathak, Myoung Sook Han, Vernon G. Coffey, Johann Edge, Donato A. Rivas, Michael F. Hirshman, Roger J. Davis, Laurie J. Goodyear
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9957b067f3d0442eac6cc8a71ac69c2e
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spelling	oai:doaj.org-article:9957b067f3d0442eac6cc8a71ac69c2e2021-12-02T16:56:57ZJNK regulates muscle remodeling via myostatin/SMAD inhibition10.1038/s41467-018-05439-32041-1723https://doaj.org/article/9957b067f3d0442eac6cc8a71ac69c2e2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05439-3https://doaj.org/toc/2041-1723Endurance and resistance exercise have different effects on skeletal muscle phenotype. Using mouse models and human subjects, the authors show that JNK/Smad2 signaling acts as molecular switch that when activated by resistance exercise leads to hypertrophy, and when inhibited promotes endurance adaptations in muscle.Sarah J. LessardTara L. MacDonaldPrerana PathakMyoung Sook HanVernon G. CoffeyJohann EdgeDonato A. RivasMichael F. HirshmanRoger J. DavisLaurie J. GoodyearNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sarah J. Lessard Tara L. MacDonald Prerana Pathak Myoung Sook Han Vernon G. Coffey Johann Edge Donato A. Rivas Michael F. Hirshman Roger J. Davis Laurie J. Goodyear JNK regulates muscle remodeling via myostatin/SMAD inhibition
description	Endurance and resistance exercise have different effects on skeletal muscle phenotype. Using mouse models and human subjects, the authors show that JNK/Smad2 signaling acts as molecular switch that when activated by resistance exercise leads to hypertrophy, and when inhibited promotes endurance adaptations in muscle.
format	article
author	Sarah J. Lessard Tara L. MacDonald Prerana Pathak Myoung Sook Han Vernon G. Coffey Johann Edge Donato A. Rivas Michael F. Hirshman Roger J. Davis Laurie J. Goodyear
author_facet	Sarah J. Lessard Tara L. MacDonald Prerana Pathak Myoung Sook Han Vernon G. Coffey Johann Edge Donato A. Rivas Michael F. Hirshman Roger J. Davis Laurie J. Goodyear
author_sort	Sarah J. Lessard
title	JNK regulates muscle remodeling via myostatin/SMAD inhibition
title_short	JNK regulates muscle remodeling via myostatin/SMAD inhibition
title_full	JNK regulates muscle remodeling via myostatin/SMAD inhibition
title_fullStr	JNK regulates muscle remodeling via myostatin/SMAD inhibition
title_full_unstemmed	JNK regulates muscle remodeling via myostatin/SMAD inhibition
title_sort	jnk regulates muscle remodeling via myostatin/smad inhibition
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9957b067f3d0442eac6cc8a71ac69c2e
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JNK regulates muscle remodeling via myostatin/SMAD inhibition

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