11C-PIB PET imaging reveals that amyloid deposition in cases with early-onset Alzheimer’s disease in the absence of known mutations retains higher levels of PIB in the basal ganglia
Young Chul Youn,1 Jae-Won Jang,2 Su-Hyun Han,1 HyeRyoun Kim,3 Ju-Won Seok,4 Jun Soo Byun,5 Kwang-Yeol Park,1 Seong Soo A An,6 In Kook Chun,7 SangYun Kim8 1Department of Neurology, Chung-Ang University College of Medicine, Seoul, 2Department of Neurology, Kangwon National University Hospital, 3Depar...
Guardado en:
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2017
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/995b8fecb64f4cd2920dd0f08d4043b5 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:995b8fecb64f4cd2920dd0f08d4043b5 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:995b8fecb64f4cd2920dd0f08d4043b52021-12-02T06:39:54Z11C-PIB PET imaging reveals that amyloid deposition in cases with early-onset Alzheimer’s disease in the absence of known mutations retains higher levels of PIB in the basal ganglia1178-1998https://doaj.org/article/995b8fecb64f4cd2920dd0f08d4043b52017-06-01T00:00:00Zhttps://www.dovepress.com/11c-pib-pet-imaging-reveals-that-amyloid-deposition-in-cases-with-earl-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Young Chul Youn,1 Jae-Won Jang,2 Su-Hyun Han,1 HyeRyoun Kim,3 Ju-Won Seok,4 Jun Soo Byun,5 Kwang-Yeol Park,1 Seong Soo A An,6 In Kook Chun,7 SangYun Kim8 1Department of Neurology, Chung-Ang University College of Medicine, Seoul, 2Department of Neurology, Kangwon National University Hospital, 3Department of Laboratory Medicine, 4Department of Nuclear Medicine, 5Department of Radiology, Chung-Ang University College of Medicine, 6College of Bionano Technology, Gachon Bionano Research Institute, Gachon University, 7Department of Nuclear Medicine, Kangwon National University Hospital, 8Department of Neurology, Seoul National University Bundang Hospital and Seoul National University College of Medicine, Gyeonggi-do, Republic of Korea Purpose: Early-onset Alzheimer’s disease (EOAD) has a different pathologic burden and clinical features compared with late-onset Alzheimer’s disease (LOAD). We examined the effects of age at onset on the burden and distribution of β-amyloid in patients with EOAD, in whom well-characterized mutations associated with Alzheimer’s disease were absent.Methods: We genotyped ApoE, APP, PSEN1 and PSEN2 in the patients with Alzheimer’s disease: 9 patients with EOAD (age <65), 11 with LOAD (age >70) and 8 normal controls (NCs), all of whom had undergone 11C-labeled Pittsburgh compound B-positron emission tomography imaging.Results: Patients with EOAD exhibited higher z scores and larger cluster sizes, and retained higher levels of Pittsburgh compound B in the bilateral thalamus and in some parts of the globus pallidus (P<0.05, false discovery rate).Conclusion: Distribution of amyloid deposition in EOAD outside the context of genetic mutations topographically showed some differences from that in LOAD. Keywords: Alzheimer’s disease, early-onset Alzheimer’s disease, amyloid PET, basal ganglia, Pittsburgh compound B, amyloid Youn YCJang JWHan SHKim HRSeok JWByun JSPark KYAn SSAChun IKKim SYDove Medical PressarticleAlzheimer disease early-onset Alzheimer disease amyloid PETGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 12, Pp 1041-1048 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Alzheimer disease early-onset Alzheimer disease amyloid PET Geriatrics RC952-954.6 |
| spellingShingle |
Alzheimer disease early-onset Alzheimer disease amyloid PET Geriatrics RC952-954.6 Youn YC Jang JW Han SH Kim HR Seok JW Byun JS Park KY An SSA Chun IK Kim SY 11C-PIB PET imaging reveals that amyloid deposition in cases with early-onset Alzheimer’s disease in the absence of known mutations retains higher levels of PIB in the basal ganglia |
| description |
Young Chul Youn,1 Jae-Won Jang,2 Su-Hyun Han,1 HyeRyoun Kim,3 Ju-Won Seok,4 Jun Soo Byun,5 Kwang-Yeol Park,1 Seong Soo A An,6 In Kook Chun,7 SangYun Kim8 1Department of Neurology, Chung-Ang University College of Medicine, Seoul, 2Department of Neurology, Kangwon National University Hospital, 3Department of Laboratory Medicine, 4Department of Nuclear Medicine, 5Department of Radiology, Chung-Ang University College of Medicine, 6College of Bionano Technology, Gachon Bionano Research Institute, Gachon University, 7Department of Nuclear Medicine, Kangwon National University Hospital, 8Department of Neurology, Seoul National University Bundang Hospital and Seoul National University College of Medicine, Gyeonggi-do, Republic of Korea Purpose: Early-onset Alzheimer’s disease (EOAD) has a different pathologic burden and clinical features compared with late-onset Alzheimer’s disease (LOAD). We examined the effects of age at onset on the burden and distribution of β-amyloid in patients with EOAD, in whom well-characterized mutations associated with Alzheimer’s disease were absent.Methods: We genotyped ApoE, APP, PSEN1 and PSEN2 in the patients with Alzheimer’s disease: 9 patients with EOAD (age <65), 11 with LOAD (age >70) and 8 normal controls (NCs), all of whom had undergone 11C-labeled Pittsburgh compound B-positron emission tomography imaging.Results: Patients with EOAD exhibited higher z scores and larger cluster sizes, and retained higher levels of Pittsburgh compound B in the bilateral thalamus and in some parts of the globus pallidus (P<0.05, false discovery rate).Conclusion: Distribution of amyloid deposition in EOAD outside the context of genetic mutations topographically showed some differences from that in LOAD. Keywords: Alzheimer’s disease, early-onset Alzheimer’s disease, amyloid PET, basal ganglia, Pittsburgh compound B, amyloid |
| format |
article |
| author |
Youn YC Jang JW Han SH Kim HR Seok JW Byun JS Park KY An SSA Chun IK Kim SY |
| author_facet |
Youn YC Jang JW Han SH Kim HR Seok JW Byun JS Park KY An SSA Chun IK Kim SY |
| author_sort |
Youn YC |
| title |
11C-PIB PET imaging reveals that amyloid deposition in cases with early-onset Alzheimer’s disease in the absence of known mutations retains higher levels of PIB in the basal ganglia |
| title_short |
11C-PIB PET imaging reveals that amyloid deposition in cases with early-onset Alzheimer’s disease in the absence of known mutations retains higher levels of PIB in the basal ganglia |
| title_full |
11C-PIB PET imaging reveals that amyloid deposition in cases with early-onset Alzheimer’s disease in the absence of known mutations retains higher levels of PIB in the basal ganglia |
| title_fullStr |
11C-PIB PET imaging reveals that amyloid deposition in cases with early-onset Alzheimer’s disease in the absence of known mutations retains higher levels of PIB in the basal ganglia |
| title_full_unstemmed |
11C-PIB PET imaging reveals that amyloid deposition in cases with early-onset Alzheimer’s disease in the absence of known mutations retains higher levels of PIB in the basal ganglia |
| title_sort |
11c-pib pet imaging reveals that amyloid deposition in cases with early-onset alzheimer’s disease in the absence of known mutations retains higher levels of pib in the basal ganglia |
| publisher |
Dove Medical Press |
| publishDate |
2017 |
| url |
https://doaj.org/article/995b8fecb64f4cd2920dd0f08d4043b5 |
| work_keys_str_mv |
AT younyc 11cpibpetimagingrevealsthatamyloiddepositionincaseswithearlyonsetalzheimerrsquosdiseaseintheabsenceofknownmutationsretainshigherlevelsofpibinthebasalganglia AT jangjw 11cpibpetimagingrevealsthatamyloiddepositionincaseswithearlyonsetalzheimerrsquosdiseaseintheabsenceofknownmutationsretainshigherlevelsofpibinthebasalganglia AT hansh 11cpibpetimagingrevealsthatamyloiddepositionincaseswithearlyonsetalzheimerrsquosdiseaseintheabsenceofknownmutationsretainshigherlevelsofpibinthebasalganglia AT kimhr 11cpibpetimagingrevealsthatamyloiddepositionincaseswithearlyonsetalzheimerrsquosdiseaseintheabsenceofknownmutationsretainshigherlevelsofpibinthebasalganglia AT seokjw 11cpibpetimagingrevealsthatamyloiddepositionincaseswithearlyonsetalzheimerrsquosdiseaseintheabsenceofknownmutationsretainshigherlevelsofpibinthebasalganglia AT byunjs 11cpibpetimagingrevealsthatamyloiddepositionincaseswithearlyonsetalzheimerrsquosdiseaseintheabsenceofknownmutationsretainshigherlevelsofpibinthebasalganglia AT parkky 11cpibpetimagingrevealsthatamyloiddepositionincaseswithearlyonsetalzheimerrsquosdiseaseintheabsenceofknownmutationsretainshigherlevelsofpibinthebasalganglia AT anssa 11cpibpetimagingrevealsthatamyloiddepositionincaseswithearlyonsetalzheimerrsquosdiseaseintheabsenceofknownmutationsretainshigherlevelsofpibinthebasalganglia AT chunik 11cpibpetimagingrevealsthatamyloiddepositionincaseswithearlyonsetalzheimerrsquosdiseaseintheabsenceofknownmutationsretainshigherlevelsofpibinthebasalganglia AT kimsy 11cpibpetimagingrevealsthatamyloiddepositionincaseswithearlyonsetalzheimerrsquosdiseaseintheabsenceofknownmutationsretainshigherlevelsofpibinthebasalganglia |
| _version_ |
1718399827594706944 |