Vascular dysfunction and its recovery after transradial coronary angioplasty- A serial observational study

Objective: To serially evaluate the effect of trans-radial coronary angioplasty (TRA) on the vascular function of radial artery (RA) and upstream brachial artery (BA) and to find out the relative contribution of endothelial dependent flow-mediated vasodilatation (FMD) and endothelial independent nit...

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Autores principales:	Naveen Garg, Arvind Singh Raghuvanshi, Aditya Kapoor, Satyendra Tewari, Roopali Khanna, Sudeep Kumar, Ankit Sahu, Pravin Kumar Goel
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Endothelial dysfunction Flow mediated dilatation Nitrate mediated dilatation Transradial catheterization Vascular function Surgery RD1-811 Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/995bc4e5b9894b638760abc00d8e9958
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spelling	oai:doaj.org-article:995bc4e5b9894b638760abc00d8e99582021-12-02T04:58:03ZVascular dysfunction and its recovery after transradial coronary angioplasty- A serial observational study0019-483210.1016/j.ihj.2021.10.010https://doaj.org/article/995bc4e5b9894b638760abc00d8e99582021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0019483221002297https://doaj.org/toc/0019-4832Objective: To serially evaluate the effect of trans-radial coronary angioplasty (TRA) on the vascular function of radial artery (RA) and upstream brachial artery (BA) and to find out the relative contribution of endothelial dependent flow-mediated vasodilatation (FMD) and endothelial independent nitrate mediated dilatation (NMD). Methods: Forty patients of chronic stable angina with successful TRA were studied. FMD and NMD of bilateral RA and BA were measured with high-resolution ultrasound, before and at 24 h and at 3 months, after catheterization. Results: FMD as well as NMD were significantly decreased in right RA (16.3 ± 3.6% to 5.7 ± 1.8%; p = 0.001, and 24.1 ± 5.3% to 9.7 ± 2.8%; p = 0.001, respectively) as well as in upstream BA (17.0 ± 1.6% to 9.4 ± 0.5%; p = 0.001,and 26.5 ± 6.8% to 20.5 ± 3.7%; p = 0.001, respectively) at 24 h. FMD/NMD ratio was also decreased in RA (70 ± 10% to 60 ± 10%; p = 0.04) and as well as in BA (70 ± 20% to 50 ± 10%; p = 0.03). The endothelial dysfunctions returned to normal at 3 months. Control arm did not show any change in vascular function at any point of time. Radial artery diameter/sheath ratio <1 and catheter exchanges >2 were the independent predictors for >50% decrease in FMD. Conclusions: TRA results in reversible depression in FMD as well as NMD in the radial artery as well as upstream brachial artery. These vascular dysfunctions are limited to the catheterized arm only and return to normal after 3 months.Naveen GargArvind Singh RaghuvanshiAditya KapoorSatyendra TewariRoopali KhannaSudeep KumarAnkit SahuPravin Kumar GoelElsevierarticleEndothelial dysfunctionFlow mediated dilatationNitrate mediated dilatationTransradial catheterizationVascular functionSurgeryRD1-811Diseases of the circulatory (Cardiovascular) systemRC666-701ENIndian Heart Journal, Vol 73, Iss 6, Pp 697-703 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Endothelial dysfunction Flow mediated dilatation Nitrate mediated dilatation Transradial catheterization Vascular function Surgery RD1-811 Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Endothelial dysfunction Flow mediated dilatation Nitrate mediated dilatation Transradial catheterization Vascular function Surgery RD1-811 Diseases of the circulatory (Cardiovascular) system RC666-701 Naveen Garg Arvind Singh Raghuvanshi Aditya Kapoor Satyendra Tewari Roopali Khanna Sudeep Kumar Ankit Sahu Pravin Kumar Goel Vascular dysfunction and its recovery after transradial coronary angioplasty- A serial observational study
description	Objective: To serially evaluate the effect of trans-radial coronary angioplasty (TRA) on the vascular function of radial artery (RA) and upstream brachial artery (BA) and to find out the relative contribution of endothelial dependent flow-mediated vasodilatation (FMD) and endothelial independent nitrate mediated dilatation (NMD). Methods: Forty patients of chronic stable angina with successful TRA were studied. FMD and NMD of bilateral RA and BA were measured with high-resolution ultrasound, before and at 24 h and at 3 months, after catheterization. Results: FMD as well as NMD were significantly decreased in right RA (16.3 ± 3.6% to 5.7 ± 1.8%; p = 0.001, and 24.1 ± 5.3% to 9.7 ± 2.8%; p = 0.001, respectively) as well as in upstream BA (17.0 ± 1.6% to 9.4 ± 0.5%; p = 0.001,and 26.5 ± 6.8% to 20.5 ± 3.7%; p = 0.001, respectively) at 24 h. FMD/NMD ratio was also decreased in RA (70 ± 10% to 60 ± 10%; p = 0.04) and as well as in BA (70 ± 20% to 50 ± 10%; p = 0.03). The endothelial dysfunctions returned to normal at 3 months. Control arm did not show any change in vascular function at any point of time. Radial artery diameter/sheath ratio <1 and catheter exchanges >2 were the independent predictors for >50% decrease in FMD. Conclusions: TRA results in reversible depression in FMD as well as NMD in the radial artery as well as upstream brachial artery. These vascular dysfunctions are limited to the catheterized arm only and return to normal after 3 months.
format	article
author	Naveen Garg Arvind Singh Raghuvanshi Aditya Kapoor Satyendra Tewari Roopali Khanna Sudeep Kumar Ankit Sahu Pravin Kumar Goel
author_facet	Naveen Garg Arvind Singh Raghuvanshi Aditya Kapoor Satyendra Tewari Roopali Khanna Sudeep Kumar Ankit Sahu Pravin Kumar Goel
author_sort	Naveen Garg
title	Vascular dysfunction and its recovery after transradial coronary angioplasty- A serial observational study
title_short	Vascular dysfunction and its recovery after transradial coronary angioplasty- A serial observational study
title_full	Vascular dysfunction and its recovery after transradial coronary angioplasty- A serial observational study
title_fullStr	Vascular dysfunction and its recovery after transradial coronary angioplasty- A serial observational study
title_full_unstemmed	Vascular dysfunction and its recovery after transradial coronary angioplasty- A serial observational study
title_sort	vascular dysfunction and its recovery after transradial coronary angioplasty- a serial observational study
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/995bc4e5b9894b638760abc00d8e9958
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Vascular dysfunction and its recovery after transradial coronary angioplasty- A serial observational study

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