The association between interferon lambda 3 and 4 gene single-nucleotide polymorphisms and the recovery of COVID-19 patients

Abstract Background The recent pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has elevated several clinical and scientific questions. These include how host genetic factors influence the pathogenesis and disease susceptibility. Therefore, the aim of this study was to...

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Autores principales:	Pooneh Rahimi, Rahil Tarharoudi, Alireza Rahimpour, Jalal Mosayebi Amroabadi, Iraj Ahmadi, Enayat Anvari, Seyed Davar Siadat, Mohammadreza Aghasadeghi, Abolfazl Fateh
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	SARS-CoV-2 COVID-19 Interferon lambda 3 Interferon lambda 4 Single-nucleotide polymorphisms Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/99639fb0836b4c7eb195aa420f692905
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spelling	oai:doaj.org-article:99639fb0836b4c7eb195aa420f6929052021-11-21T12:02:04ZThe association between interferon lambda 3 and 4 gene single-nucleotide polymorphisms and the recovery of COVID-19 patients10.1186/s12985-021-01692-z1743-422Xhttps://doaj.org/article/99639fb0836b4c7eb195aa420f6929052021-11-01T00:00:00Zhttps://doi.org/10.1186/s12985-021-01692-zhttps://doaj.org/toc/1743-422XAbstract Background The recent pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has elevated several clinical and scientific questions. These include how host genetic factors influence the pathogenesis and disease susceptibility. Therefore, the aim of this study was to evaluate the impact of interferon lambda 3 and 4 (IFNL3/4) gene polymorphisms and clinical parameters on the resistance and susceptibility to coronavirus disease 2019 (COVID-19) infection. Methods A total of 750 SARS-CoV-2 positive patients (375 survivors and 375 nonsurvivors) were included in this study. All single-nucleotide polymorphisms (SNPs) on IFNL3 (rs12979860, rs8099917, and rs12980275) and IFNL4 rs368234815 were genotyped by the polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP) method. Results In this study, a higher viral load (low PCR Ct value) was shown in nonsurvivor patients. In survivor patients, the frequency of the favorable genotypes of IFNL3/4 SNPs (rs12979860 CC, rs12980275 AA, rs8099917 TT, and rs368234815 TT/TT) was significantly higher than in nonsurvivor patients. Multivariate logistic regression analysis has shown that a higher low-density lipoprotein (LDL), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and PCR Ct value, and lower 25-hydroxyvitamin D, and also IFNL3 rs12979860 TT, IFNL3 rs8099917 GG, IFNL3 rs12980275 GG, and IFNL4 rs368234815 ∆G/∆G genotypes were associated with the severity of COVID-19 infection. Conclusions The results of this study proved that the severity of COVID-19 infection was associated with clinical parameters and unfavorable genotypes of IFNL3/IFNL4 SNPs. Further studies in different parts of the world are needed to show the relationship between severity of COVID-19 infection and host genetic factors.Pooneh RahimiRahil TarharoudiAlireza RahimpourJalal Mosayebi AmroabadiIraj AhmadiEnayat AnvariSeyed Davar SiadatMohammadreza AghasadeghiAbolfazl FatehBMCarticleSARS-CoV-2COVID-19Interferon lambda 3Interferon lambda 4Single-nucleotide polymorphismsInfectious and parasitic diseasesRC109-216ENVirology Journal, Vol 18, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV-2 COVID-19 Interferon lambda 3 Interferon lambda 4 Single-nucleotide polymorphisms Infectious and parasitic diseases RC109-216
spellingShingle	SARS-CoV-2 COVID-19 Interferon lambda 3 Interferon lambda 4 Single-nucleotide polymorphisms Infectious and parasitic diseases RC109-216 Pooneh Rahimi Rahil Tarharoudi Alireza Rahimpour Jalal Mosayebi Amroabadi Iraj Ahmadi Enayat Anvari Seyed Davar Siadat Mohammadreza Aghasadeghi Abolfazl Fateh The association between interferon lambda 3 and 4 gene single-nucleotide polymorphisms and the recovery of COVID-19 patients
description	Abstract Background The recent pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has elevated several clinical and scientific questions. These include how host genetic factors influence the pathogenesis and disease susceptibility. Therefore, the aim of this study was to evaluate the impact of interferon lambda 3 and 4 (IFNL3/4) gene polymorphisms and clinical parameters on the resistance and susceptibility to coronavirus disease 2019 (COVID-19) infection. Methods A total of 750 SARS-CoV-2 positive patients (375 survivors and 375 nonsurvivors) were included in this study. All single-nucleotide polymorphisms (SNPs) on IFNL3 (rs12979860, rs8099917, and rs12980275) and IFNL4 rs368234815 were genotyped by the polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP) method. Results In this study, a higher viral load (low PCR Ct value) was shown in nonsurvivor patients. In survivor patients, the frequency of the favorable genotypes of IFNL3/4 SNPs (rs12979860 CC, rs12980275 AA, rs8099917 TT, and rs368234815 TT/TT) was significantly higher than in nonsurvivor patients. Multivariate logistic regression analysis has shown that a higher low-density lipoprotein (LDL), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and PCR Ct value, and lower 25-hydroxyvitamin D, and also IFNL3 rs12979860 TT, IFNL3 rs8099917 GG, IFNL3 rs12980275 GG, and IFNL4 rs368234815 ∆G/∆G genotypes were associated with the severity of COVID-19 infection. Conclusions The results of this study proved that the severity of COVID-19 infection was associated with clinical parameters and unfavorable genotypes of IFNL3/IFNL4 SNPs. Further studies in different parts of the world are needed to show the relationship between severity of COVID-19 infection and host genetic factors.
format	article
author	Pooneh Rahimi Rahil Tarharoudi Alireza Rahimpour Jalal Mosayebi Amroabadi Iraj Ahmadi Enayat Anvari Seyed Davar Siadat Mohammadreza Aghasadeghi Abolfazl Fateh
author_facet	Pooneh Rahimi Rahil Tarharoudi Alireza Rahimpour Jalal Mosayebi Amroabadi Iraj Ahmadi Enayat Anvari Seyed Davar Siadat Mohammadreza Aghasadeghi Abolfazl Fateh
author_sort	Pooneh Rahimi
title	The association between interferon lambda 3 and 4 gene single-nucleotide polymorphisms and the recovery of COVID-19 patients
title_short	The association between interferon lambda 3 and 4 gene single-nucleotide polymorphisms and the recovery of COVID-19 patients
title_full	The association between interferon lambda 3 and 4 gene single-nucleotide polymorphisms and the recovery of COVID-19 patients
title_fullStr	The association between interferon lambda 3 and 4 gene single-nucleotide polymorphisms and the recovery of COVID-19 patients
title_full_unstemmed	The association between interferon lambda 3 and 4 gene single-nucleotide polymorphisms and the recovery of COVID-19 patients
title_sort	association between interferon lambda 3 and 4 gene single-nucleotide polymorphisms and the recovery of covid-19 patients
publisher	BMC
publishDate	2021
url	https://doaj.org/article/99639fb0836b4c7eb195aa420f692905
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The association between interferon lambda 3 and 4 gene single-nucleotide polymorphisms and the recovery of COVID-19 patients

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