Osteoprotegerin-dependent M cell self-regulation balances gut infection and immunity

Microfold cells (M cells) sit at the gut epithelial surface to sample antigens and maintain local immune homeostasis. Here the authors show that M cells are feedback-regulated by M cell-originated osteoprotegerin (OPG) to suppress RNAKL-induced M cell differentiation, and that OPG deficiency alters...

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Autores principales:	Shunsuke Kimura, Yutaka Nakamura, Nobuhide Kobayashi, Katsuyuki Shiroguchi, Eiryo Kawakami, Mami Mutoh, Hiromi Takahashi-Iwanaga, Takahiro Yamada, Meri Hisamoto, Midori Nakamura, Nobuyuki Udagawa, Shintaro Sato, Tsuneyasu Kaisho, Toshihiko Iwanaga, Koji Hase
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/99645e0b7f85428f9c603bf38fe18aa1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:99645e0b7f85428f9c603bf38fe18aa12021-12-02T14:41:03ZOsteoprotegerin-dependent M cell self-regulation balances gut infection and immunity10.1038/s41467-019-13883-y2041-1723https://doaj.org/article/99645e0b7f85428f9c603bf38fe18aa12020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13883-yhttps://doaj.org/toc/2041-1723Microfold cells (M cells) sit at the gut epithelial surface to sample antigens and maintain local immune homeostasis. Here the authors show that M cells are feedback-regulated by M cell-originated osteoprotegerin (OPG) to suppress RNAKL-induced M cell differentiation, and that OPG deficiency alters both gut colitis and infection phenotypes.Shunsuke KimuraYutaka NakamuraNobuhide KobayashiKatsuyuki ShiroguchiEiryo KawakamiMami MutohHiromi Takahashi-IwanagaTakahiro YamadaMeri HisamotoMidori NakamuraNobuyuki UdagawaShintaro SatoTsuneyasu KaishoToshihiko IwanagaKoji HaseNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shunsuke Kimura Yutaka Nakamura Nobuhide Kobayashi Katsuyuki Shiroguchi Eiryo Kawakami Mami Mutoh Hiromi Takahashi-Iwanaga Takahiro Yamada Meri Hisamoto Midori Nakamura Nobuyuki Udagawa Shintaro Sato Tsuneyasu Kaisho Toshihiko Iwanaga Koji Hase Osteoprotegerin-dependent M cell self-regulation balances gut infection and immunity
description	Microfold cells (M cells) sit at the gut epithelial surface to sample antigens and maintain local immune homeostasis. Here the authors show that M cells are feedback-regulated by M cell-originated osteoprotegerin (OPG) to suppress RNAKL-induced M cell differentiation, and that OPG deficiency alters both gut colitis and infection phenotypes.
format	article
author	Shunsuke Kimura Yutaka Nakamura Nobuhide Kobayashi Katsuyuki Shiroguchi Eiryo Kawakami Mami Mutoh Hiromi Takahashi-Iwanaga Takahiro Yamada Meri Hisamoto Midori Nakamura Nobuyuki Udagawa Shintaro Sato Tsuneyasu Kaisho Toshihiko Iwanaga Koji Hase
author_facet	Shunsuke Kimura Yutaka Nakamura Nobuhide Kobayashi Katsuyuki Shiroguchi Eiryo Kawakami Mami Mutoh Hiromi Takahashi-Iwanaga Takahiro Yamada Meri Hisamoto Midori Nakamura Nobuyuki Udagawa Shintaro Sato Tsuneyasu Kaisho Toshihiko Iwanaga Koji Hase
author_sort	Shunsuke Kimura
title	Osteoprotegerin-dependent M cell self-regulation balances gut infection and immunity
title_short	Osteoprotegerin-dependent M cell self-regulation balances gut infection and immunity
title_full	Osteoprotegerin-dependent M cell self-regulation balances gut infection and immunity
title_fullStr	Osteoprotegerin-dependent M cell self-regulation balances gut infection and immunity
title_full_unstemmed	Osteoprotegerin-dependent M cell self-regulation balances gut infection and immunity
title_sort	osteoprotegerin-dependent m cell self-regulation balances gut infection and immunity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/99645e0b7f85428f9c603bf38fe18aa1
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Osteoprotegerin-dependent M cell self-regulation balances gut infection and immunity

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