Molecular and functional heterogeneity of IL-10-producing CD4 + T cells

Tr1 cells are considered an immunosuppressive CD4 T cell population producing IL-10. Here the authors show that IL-10 is insufficient for Tr1 immunosuppression, define surface markers and transcriptional program of the immunosuppressive subset within Tr1, and reveal its deficiency in patients with I...

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Autores principales:	Leonie Brockmann, Shiwa Soukou, Babett Steglich, Paulo Czarnewski, Lilan Zhao, Sandra Wende, Tanja Bedke, Can Ergen, Carolin Manthey, Theodora Agalioti, Maria Geffken, Oliver Seiz, Sara M. Parigi, Chiara Sorini, Jens Geginat, Keishi Fujio, Thomas Jacobs, Thomas Roesch, Jacob R. Izbicki, Ansgar W. Lohse, Richard A. Flavell, Christian Krebs, Jan-Ake Gustafsson, Per Antonson, Maria Grazia Roncarolo, Eduardo J. Villablanca, Nicola Gagliani, Samuel Huber
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9965d7bfb0694a05899ad6316109497d
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spelling	oai:doaj.org-article:9965d7bfb0694a05899ad6316109497d2021-12-02T17:32:45ZMolecular and functional heterogeneity of IL-10-producing CD4 + T cells10.1038/s41467-018-07581-42041-1723https://doaj.org/article/9965d7bfb0694a05899ad6316109497d2018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07581-4https://doaj.org/toc/2041-1723Tr1 cells are considered an immunosuppressive CD4 T cell population producing IL-10. Here the authors show that IL-10 is insufficient for Tr1 immunosuppression, define surface markers and transcriptional program of the immunosuppressive subset within Tr1, and reveal its deficiency in patients with IBD.Leonie BrockmannShiwa SoukouBabett SteglichPaulo CzarnewskiLilan ZhaoSandra WendeTanja BedkeCan ErgenCarolin MantheyTheodora AgaliotiMaria GeffkenOliver SeizSara M. ParigiChiara SoriniJens GeginatKeishi FujioThomas JacobsThomas RoeschJacob R. IzbickiAnsgar W. LohseRichard A. FlavellChristian KrebsJan-Ake GustafssonPer AntonsonMaria Grazia RoncaroloEduardo J. VillablancaNicola GaglianiSamuel HuberNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Leonie Brockmann Shiwa Soukou Babett Steglich Paulo Czarnewski Lilan Zhao Sandra Wende Tanja Bedke Can Ergen Carolin Manthey Theodora Agalioti Maria Geffken Oliver Seiz Sara M. Parigi Chiara Sorini Jens Geginat Keishi Fujio Thomas Jacobs Thomas Roesch Jacob R. Izbicki Ansgar W. Lohse Richard A. Flavell Christian Krebs Jan-Ake Gustafsson Per Antonson Maria Grazia Roncarolo Eduardo J. Villablanca Nicola Gagliani Samuel Huber Molecular and functional heterogeneity of IL-10-producing CD4 + T cells
description	Tr1 cells are considered an immunosuppressive CD4 T cell population producing IL-10. Here the authors show that IL-10 is insufficient for Tr1 immunosuppression, define surface markers and transcriptional program of the immunosuppressive subset within Tr1, and reveal its deficiency in patients with IBD.
format	article
author	Leonie Brockmann Shiwa Soukou Babett Steglich Paulo Czarnewski Lilan Zhao Sandra Wende Tanja Bedke Can Ergen Carolin Manthey Theodora Agalioti Maria Geffken Oliver Seiz Sara M. Parigi Chiara Sorini Jens Geginat Keishi Fujio Thomas Jacobs Thomas Roesch Jacob R. Izbicki Ansgar W. Lohse Richard A. Flavell Christian Krebs Jan-Ake Gustafsson Per Antonson Maria Grazia Roncarolo Eduardo J. Villablanca Nicola Gagliani Samuel Huber
author_facet	Leonie Brockmann Shiwa Soukou Babett Steglich Paulo Czarnewski Lilan Zhao Sandra Wende Tanja Bedke Can Ergen Carolin Manthey Theodora Agalioti Maria Geffken Oliver Seiz Sara M. Parigi Chiara Sorini Jens Geginat Keishi Fujio Thomas Jacobs Thomas Roesch Jacob R. Izbicki Ansgar W. Lohse Richard A. Flavell Christian Krebs Jan-Ake Gustafsson Per Antonson Maria Grazia Roncarolo Eduardo J. Villablanca Nicola Gagliani Samuel Huber
author_sort	Leonie Brockmann
title	Molecular and functional heterogeneity of IL-10-producing CD4 + T cells
title_short	Molecular and functional heterogeneity of IL-10-producing CD4 + T cells
title_full	Molecular and functional heterogeneity of IL-10-producing CD4 + T cells
title_fullStr	Molecular and functional heterogeneity of IL-10-producing CD4 + T cells
title_full_unstemmed	Molecular and functional heterogeneity of IL-10-producing CD4 + T cells
title_sort	molecular and functional heterogeneity of il-10-producing cd4 + t cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9965d7bfb0694a05899ad6316109497d
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Molecular and functional heterogeneity of IL-10-producing CD4 + T cells

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