Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation

Sox2 regulates pluripotency in neural progenitor cells (NPC) but how protein stability affects this is unclear. Here, the authors identify changes in ubiquitylation of Sox2 (by CUL4A-DET1-COP1 ligase and OTUD7B deubiquitylase) as controlling protein stability and so the differentiation state of NPCs...

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Autores principales:	Chun-Ping Cui, Yuan Zhang, Chanjuan Wang, Fang Yuan, Hongchang Li, Yuying Yao, Yuhan Chen, Chunnan Li, Wenyi Wei, Cui Hua Liu, Fuchu He, Yan Liu, Lingqiang Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9968a0cee26a49b196f872459644da56
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spelling	oai:doaj.org-article:9968a0cee26a49b196f872459644da562021-12-02T14:39:28ZDynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation10.1038/s41467-018-07025-z2041-1723https://doaj.org/article/9968a0cee26a49b196f872459644da562018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07025-zhttps://doaj.org/toc/2041-1723Sox2 regulates pluripotency in neural progenitor cells (NPC) but how protein stability affects this is unclear. Here, the authors identify changes in ubiquitylation of Sox2 (by CUL4A-DET1-COP1 ligase and OTUD7B deubiquitylase) as controlling protein stability and so the differentiation state of NPCs.Chun-Ping CuiYuan ZhangChanjuan WangFang YuanHongchang LiYuying YaoYuhan ChenChunnan LiWenyi WeiCui Hua LiuFuchu HeYan LiuLingqiang ZhangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chun-Ping Cui Yuan Zhang Chanjuan Wang Fang Yuan Hongchang Li Yuying Yao Yuhan Chen Chunnan Li Wenyi Wei Cui Hua Liu Fuchu He Yan Liu Lingqiang Zhang Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation
description	Sox2 regulates pluripotency in neural progenitor cells (NPC) but how protein stability affects this is unclear. Here, the authors identify changes in ubiquitylation of Sox2 (by CUL4A-DET1-COP1 ligase and OTUD7B deubiquitylase) as controlling protein stability and so the differentiation state of NPCs.
format	article
author	Chun-Ping Cui Yuan Zhang Chanjuan Wang Fang Yuan Hongchang Li Yuying Yao Yuhan Chen Chunnan Li Wenyi Wei Cui Hua Liu Fuchu He Yan Liu Lingqiang Zhang
author_facet	Chun-Ping Cui Yuan Zhang Chanjuan Wang Fang Yuan Hongchang Li Yuying Yao Yuhan Chen Chunnan Li Wenyi Wei Cui Hua Liu Fuchu He Yan Liu Lingqiang Zhang
author_sort	Chun-Ping Cui
title	Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation
title_short	Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation
title_full	Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation
title_fullStr	Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation
title_full_unstemmed	Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation
title_sort	dynamic ubiquitylation of sox2 regulates proteostasis and governs neural progenitor cell differentiation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9968a0cee26a49b196f872459644da56
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Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation

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