A semisynthetic Atg3 reveals that acetylation promotes Atg3 membrane binding and Atg8 lipidation

Acetylation of Atg3 regulates lipidation of Atg8 and therefore autophagy, but the molecular mechanisms remain unclear. Here, Liet al. semi-synthesize diacetylated Atg3, allowing them to show that acetylated Atg3 enhances Atg8 lipidation by promoting interaction of Atg3 with liposomes containing phys...

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Autores principales:	Yi-Tong Li, Cong Yi, Chen-Chen Chen, Huan Lan, Man Pan, Shao-Jin Zhang, Yi-Chao Huang, Chao-Jian Guan, Yi-Ming Li, Li Yu, Lei Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/996b13abaf3f4b26a3749dc108a6dce0
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spelling	oai:doaj.org-article:996b13abaf3f4b26a3749dc108a6dce02021-12-02T15:38:32ZA semisynthetic Atg3 reveals that acetylation promotes Atg3 membrane binding and Atg8 lipidation10.1038/ncomms148462041-1723https://doaj.org/article/996b13abaf3f4b26a3749dc108a6dce02017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14846https://doaj.org/toc/2041-1723Acetylation of Atg3 regulates lipidation of Atg8 and therefore autophagy, but the molecular mechanisms remain unclear. Here, Liet al. semi-synthesize diacetylated Atg3, allowing them to show that acetylated Atg3 enhances Atg8 lipidation by promoting interaction of Atg3 with liposomes containing physiological levels of phosphatidylethanolamine.Yi-Tong LiCong YiChen-Chen ChenHuan LanMan PanShao-Jin ZhangYi-Chao HuangChao-Jian GuanYi-Ming LiLi YuLei LiuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yi-Tong Li Cong Yi Chen-Chen Chen Huan Lan Man Pan Shao-Jin Zhang Yi-Chao Huang Chao-Jian Guan Yi-Ming Li Li Yu Lei Liu A semisynthetic Atg3 reveals that acetylation promotes Atg3 membrane binding and Atg8 lipidation
description	Acetylation of Atg3 regulates lipidation of Atg8 and therefore autophagy, but the molecular mechanisms remain unclear. Here, Liet al. semi-synthesize diacetylated Atg3, allowing them to show that acetylated Atg3 enhances Atg8 lipidation by promoting interaction of Atg3 with liposomes containing physiological levels of phosphatidylethanolamine.
format	article
author	Yi-Tong Li Cong Yi Chen-Chen Chen Huan Lan Man Pan Shao-Jin Zhang Yi-Chao Huang Chao-Jian Guan Yi-Ming Li Li Yu Lei Liu
author_facet	Yi-Tong Li Cong Yi Chen-Chen Chen Huan Lan Man Pan Shao-Jin Zhang Yi-Chao Huang Chao-Jian Guan Yi-Ming Li Li Yu Lei Liu
author_sort	Yi-Tong Li
title	A semisynthetic Atg3 reveals that acetylation promotes Atg3 membrane binding and Atg8 lipidation
title_short	A semisynthetic Atg3 reveals that acetylation promotes Atg3 membrane binding and Atg8 lipidation
title_full	A semisynthetic Atg3 reveals that acetylation promotes Atg3 membrane binding and Atg8 lipidation
title_fullStr	A semisynthetic Atg3 reveals that acetylation promotes Atg3 membrane binding and Atg8 lipidation
title_full_unstemmed	A semisynthetic Atg3 reveals that acetylation promotes Atg3 membrane binding and Atg8 lipidation
title_sort	semisynthetic atg3 reveals that acetylation promotes atg3 membrane binding and atg8 lipidation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/996b13abaf3f4b26a3749dc108a6dce0
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A semisynthetic Atg3 reveals that acetylation promotes Atg3 membrane binding and Atg8 lipidation

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