Altered expression of type-1 and type-2 cannabinoid receptors in celiac disease.

Anandamide (AEA) is the prominent member of the endocannabinoid family and its biological action is mediated through the binding to both type-1 (CB1) and type-2 (CB2) cannabinoid receptors (CBR). The presence of AEA and CBR in the gastrointestinal tract highlighted their pathophysiological role in s...

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Autores principales:	Natalia Battista, Antonio Di Sabatino, Monia Di Tommaso, Paolo Biancheri, Cinzia Rapino, Paolo Giuffrida, Cinzia Papadia, Chiara Montana, Alessandra Pasini, Alessandro Vanoli, Francesco Lanzarotto, Vincenzo Villanacci, Gino R Corazza, Mauro Maccarrone
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/996dc2913ad448be9a40d5f92ea22f04
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spelling	oai:doaj.org-article:996dc2913ad448be9a40d5f92ea22f042021-11-18T07:48:41ZAltered expression of type-1 and type-2 cannabinoid receptors in celiac disease.1932-620310.1371/journal.pone.0062078https://doaj.org/article/996dc2913ad448be9a40d5f92ea22f042013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23620805/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Anandamide (AEA) is the prominent member of the endocannabinoid family and its biological action is mediated through the binding to both type-1 (CB1) and type-2 (CB2) cannabinoid receptors (CBR). The presence of AEA and CBR in the gastrointestinal tract highlighted their pathophysiological role in several gut diseases, including celiac disease. Here, we aimed to investigate the expression of CBR at transcriptional and translational levels in the duodenal mucosa of untreated celiac patients, celiac patients on a gluten-free diet for at least 12 months and control subjects. Also biopsies from treated celiac patients cultured ex vivo with peptic-tryptic digest of gliadin were investigated. Our data show higher levels of both CB1 and CB2 receptors during active disease and normal CBR levels in treated celiac patients. In conclusion, we demonstrate an up-regulation of CB1 and CB2 mRNA and protein expression, that points to the therapeutic potential of targeting CBR in patients with celiac disease.Natalia BattistaAntonio Di SabatinoMonia Di TommasoPaolo BiancheriCinzia RapinoPaolo GiuffridaCinzia PapadiaChiara MontanaAlessandra PasiniAlessandro VanoliFrancesco LanzarottoVincenzo VillanacciGino R CorazzaMauro MaccarronePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e62078 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Natalia Battista Antonio Di Sabatino Monia Di Tommaso Paolo Biancheri Cinzia Rapino Paolo Giuffrida Cinzia Papadia Chiara Montana Alessandra Pasini Alessandro Vanoli Francesco Lanzarotto Vincenzo Villanacci Gino R Corazza Mauro Maccarrone Altered expression of type-1 and type-2 cannabinoid receptors in celiac disease.
description	Anandamide (AEA) is the prominent member of the endocannabinoid family and its biological action is mediated through the binding to both type-1 (CB1) and type-2 (CB2) cannabinoid receptors (CBR). The presence of AEA and CBR in the gastrointestinal tract highlighted their pathophysiological role in several gut diseases, including celiac disease. Here, we aimed to investigate the expression of CBR at transcriptional and translational levels in the duodenal mucosa of untreated celiac patients, celiac patients on a gluten-free diet for at least 12 months and control subjects. Also biopsies from treated celiac patients cultured ex vivo with peptic-tryptic digest of gliadin were investigated. Our data show higher levels of both CB1 and CB2 receptors during active disease and normal CBR levels in treated celiac patients. In conclusion, we demonstrate an up-regulation of CB1 and CB2 mRNA and protein expression, that points to the therapeutic potential of targeting CBR in patients with celiac disease.
format	article
author	Natalia Battista Antonio Di Sabatino Monia Di Tommaso Paolo Biancheri Cinzia Rapino Paolo Giuffrida Cinzia Papadia Chiara Montana Alessandra Pasini Alessandro Vanoli Francesco Lanzarotto Vincenzo Villanacci Gino R Corazza Mauro Maccarrone
author_facet	Natalia Battista Antonio Di Sabatino Monia Di Tommaso Paolo Biancheri Cinzia Rapino Paolo Giuffrida Cinzia Papadia Chiara Montana Alessandra Pasini Alessandro Vanoli Francesco Lanzarotto Vincenzo Villanacci Gino R Corazza Mauro Maccarrone
author_sort	Natalia Battista
title	Altered expression of type-1 and type-2 cannabinoid receptors in celiac disease.
title_short	Altered expression of type-1 and type-2 cannabinoid receptors in celiac disease.
title_full	Altered expression of type-1 and type-2 cannabinoid receptors in celiac disease.
title_fullStr	Altered expression of type-1 and type-2 cannabinoid receptors in celiac disease.
title_full_unstemmed	Altered expression of type-1 and type-2 cannabinoid receptors in celiac disease.
title_sort	altered expression of type-1 and type-2 cannabinoid receptors in celiac disease.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/996dc2913ad448be9a40d5f92ea22f04
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Altered expression of type-1 and type-2 cannabinoid receptors in celiac disease.

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