Differential lipids in pregnant women with subclinical hypothyroidism and their correlation to the pregnancy outcomes
Abstract Subclinical hypothyroidism (SCH) has become a prevalent complication in pregnancy. Recent research links SCH to disturbed thyroid lipid profile; however, it is unclear how lipid metabolism disorders contribute to the pathogenesis of SCH during pregnancy. Thus, we used nontargeted lipidomics...
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Nature Portfolio
2021
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oai:doaj.org-article:9970b421f6264c729381cbe7142efde12021-12-02T19:16:19ZDifferential lipids in pregnant women with subclinical hypothyroidism and their correlation to the pregnancy outcomes10.1038/s41598-021-99252-62045-2322https://doaj.org/article/9970b421f6264c729381cbe7142efde12021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99252-6https://doaj.org/toc/2045-2322Abstract Subclinical hypothyroidism (SCH) has become a prevalent complication in pregnancy. Recent research links SCH to disturbed thyroid lipid profile; however, it is unclear how lipid metabolism disorders contribute to the pathogenesis of SCH during pregnancy. Thus, we used nontargeted lipidomics to identify and compare the lipids and metabolites expressed by pregnant women with SCH and healthy pregnant women. Multivariate analysis revealed 143 lipid molecules differentially expressed between the SCH group and the control group. Based on fold change, 30 differentially expressed lipid metabolites are potential biomarkers. KEGG pathway enrichment analysis showed that the differentially expressed metabolites participate in several pathways, including response to pathogenic Escherichia coli infection, regulation of lipolysis in adipocytes, metabolic pathways, glycerophospholipid metabolism, and fat digestion and absorption pathways. Correlation analyses revealed sphingomyelin (SM) and phosphatidylcholine (PC) positively correlate to tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), and interleukin-6 (IL-6), while phosphatidylglycerol (PG), and phosphatidylinositol (PI) negatively correlate with them. In addition, PG positively correlates to birth weight. Thus, the lipid profile of pregnant women with SCH is significantly different from that of healthy pregnant women. Lipid molecules associated with the differential lipid metabolism, such as SM, phosphatidylethanolamine (PE), and PI, should be further investigated for their roles in the pathogenesis of SCH in pregnancy, as they might be targets for reducing the incidence of adverse pregnancy outcomes.Jingjing LiYajuan XuZongzong SunYanjun CaiBiao WangMiao ZhangYanjie BanXiaofeng HouYingqi HaoQian OuyangBo WuMengqi WangWentao WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) |
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Medicine R Science Q Jingjing Li Yajuan Xu Zongzong Sun Yanjun Cai Biao Wang Miao Zhang Yanjie Ban Xiaofeng Hou Yingqi Hao Qian Ouyang Bo Wu Mengqi Wang Wentao Wang Differential lipids in pregnant women with subclinical hypothyroidism and their correlation to the pregnancy outcomes |
| description |
Abstract Subclinical hypothyroidism (SCH) has become a prevalent complication in pregnancy. Recent research links SCH to disturbed thyroid lipid profile; however, it is unclear how lipid metabolism disorders contribute to the pathogenesis of SCH during pregnancy. Thus, we used nontargeted lipidomics to identify and compare the lipids and metabolites expressed by pregnant women with SCH and healthy pregnant women. Multivariate analysis revealed 143 lipid molecules differentially expressed between the SCH group and the control group. Based on fold change, 30 differentially expressed lipid metabolites are potential biomarkers. KEGG pathway enrichment analysis showed that the differentially expressed metabolites participate in several pathways, including response to pathogenic Escherichia coli infection, regulation of lipolysis in adipocytes, metabolic pathways, glycerophospholipid metabolism, and fat digestion and absorption pathways. Correlation analyses revealed sphingomyelin (SM) and phosphatidylcholine (PC) positively correlate to tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), and interleukin-6 (IL-6), while phosphatidylglycerol (PG), and phosphatidylinositol (PI) negatively correlate with them. In addition, PG positively correlates to birth weight. Thus, the lipid profile of pregnant women with SCH is significantly different from that of healthy pregnant women. Lipid molecules associated with the differential lipid metabolism, such as SM, phosphatidylethanolamine (PE), and PI, should be further investigated for their roles in the pathogenesis of SCH in pregnancy, as they might be targets for reducing the incidence of adverse pregnancy outcomes. |
| format |
article |
| author |
Jingjing Li Yajuan Xu Zongzong Sun Yanjun Cai Biao Wang Miao Zhang Yanjie Ban Xiaofeng Hou Yingqi Hao Qian Ouyang Bo Wu Mengqi Wang Wentao Wang |
| author_facet |
Jingjing Li Yajuan Xu Zongzong Sun Yanjun Cai Biao Wang Miao Zhang Yanjie Ban Xiaofeng Hou Yingqi Hao Qian Ouyang Bo Wu Mengqi Wang Wentao Wang |
| author_sort |
Jingjing Li |
| title |
Differential lipids in pregnant women with subclinical hypothyroidism and their correlation to the pregnancy outcomes |
| title_short |
Differential lipids in pregnant women with subclinical hypothyroidism and their correlation to the pregnancy outcomes |
| title_full |
Differential lipids in pregnant women with subclinical hypothyroidism and their correlation to the pregnancy outcomes |
| title_fullStr |
Differential lipids in pregnant women with subclinical hypothyroidism and their correlation to the pregnancy outcomes |
| title_full_unstemmed |
Differential lipids in pregnant women with subclinical hypothyroidism and their correlation to the pregnancy outcomes |
| title_sort |
differential lipids in pregnant women with subclinical hypothyroidism and their correlation to the pregnancy outcomes |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/9970b421f6264c729381cbe7142efde1 |
| work_keys_str_mv |
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