Skin and mucosal manifestations in patients with Thalassemia major

Objective: β-Thalassemia major is one of the common genetic disorders in Iran. In Isfahan, the prevalence of gene carriers is about 8%. As yet, no much information about skin manifestations of these patients has been published. This study was done to evaluate skin manifestations in thalassemia major...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	A Momeni, M Adabi, M Amin Javaheri, H Hoorfar
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2001
Materias:	thalassemia skin manifestations mucosal manifestations Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/99719f960e7f4c288839a9ea52976933
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:99719f960e7f4c288839a9ea52976933
record_format	dspace
spelling	oai:doaj.org-article:99719f960e7f4c288839a9ea529769332021-11-10T09:21:00ZSkin and mucosal manifestations in patients with Thalassemia major1561-41072251-7170https://doaj.org/article/99719f960e7f4c288839a9ea529769332001-04-01T00:00:00Zhttp://jbums.org/article-1-2874-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170Objective: β-Thalassemia major is one of the common genetic disorders in Iran. In Isfahan, the prevalence of gene carriers is about 8%. As yet, no much information about skin manifestations of these patients has been published. This study was done to evaluate skin manifestations in thalassemia major patients and compared them with laboratory and pathologic findings. Methods: 367 cases of β-thalassemia major who referred to this center, were clinically examined during (1998-99). Routine and special lab tests were done on all cases and skin biopsy was done on selected cases. The findings were analyzed by statistical methods and compared with the sex, age, serum ferritin, thyroid hormone level, liver enzymes and amount of injected desferal. Findings: Skin dryness (53%), freckling (33%), lentigo (28%), coarse hair (24%), scar and hyperpigmentation at the desferal injection site (28% and 30% respectively), distal nail brittleness (23%), nail plate roughness (21%) and hard palate pigmentation (30%) were the most common findings. Some skin lesions related to sage, sex, serum ferritin level, thyroid hormone and hemoglobin. All lesions, except hair and skin dryness, were severe in older patients. Conclusion: Skin and mucosal manifestations are common in thalassemia major cases. Most manifestations are related to iron deposition in skin and other organs and incomplete treatment by present methods.A MomeniM AdabiM Amin JavaheriH HoorfarBabol University of Medical Sciencesarticlethalassemiaskin manifestationsmucosal manifestationsMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 3, Iss 2, Pp 38-46 (2001)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	thalassemia skin manifestations mucosal manifestations Medicine R Medicine (General) R5-920
spellingShingle	thalassemia skin manifestations mucosal manifestations Medicine R Medicine (General) R5-920 A Momeni M Adabi M Amin Javaheri H Hoorfar Skin and mucosal manifestations in patients with Thalassemia major
description	Objective: β-Thalassemia major is one of the common genetic disorders in Iran. In Isfahan, the prevalence of gene carriers is about 8%. As yet, no much information about skin manifestations of these patients has been published. This study was done to evaluate skin manifestations in thalassemia major patients and compared them with laboratory and pathologic findings. Methods: 367 cases of β-thalassemia major who referred to this center, were clinically examined during (1998-99). Routine and special lab tests were done on all cases and skin biopsy was done on selected cases. The findings were analyzed by statistical methods and compared with the sex, age, serum ferritin, thyroid hormone level, liver enzymes and amount of injected desferal. Findings: Skin dryness (53%), freckling (33%), lentigo (28%), coarse hair (24%), scar and hyperpigmentation at the desferal injection site (28% and 30% respectively), distal nail brittleness (23%), nail plate roughness (21%) and hard palate pigmentation (30%) were the most common findings. Some skin lesions related to sage, sex, serum ferritin level, thyroid hormone and hemoglobin. All lesions, except hair and skin dryness, were severe in older patients. Conclusion: Skin and mucosal manifestations are common in thalassemia major cases. Most manifestations are related to iron deposition in skin and other organs and incomplete treatment by present methods.
format	article
author	A Momeni M Adabi M Amin Javaheri H Hoorfar
author_facet	A Momeni M Adabi M Amin Javaheri H Hoorfar
author_sort	A Momeni
title	Skin and mucosal manifestations in patients with Thalassemia major
title_short	Skin and mucosal manifestations in patients with Thalassemia major
title_full	Skin and mucosal manifestations in patients with Thalassemia major
title_fullStr	Skin and mucosal manifestations in patients with Thalassemia major
title_full_unstemmed	Skin and mucosal manifestations in patients with Thalassemia major
title_sort	skin and mucosal manifestations in patients with thalassemia major
publisher	Babol University of Medical Sciences
publishDate	2001
url	https://doaj.org/article/99719f960e7f4c288839a9ea52976933
work_keys_str_mv	AT amomeni skinandmucosalmanifestationsinpatientswiththalassemiamajor AT madabi skinandmucosalmanifestationsinpatientswiththalassemiamajor AT maminjavaheri skinandmucosalmanifestationsinpatientswiththalassemiamajor AT hhoorfar skinandmucosalmanifestationsinpatientswiththalassemiamajor
_version_	1718440121245630464

Skin and mucosal manifestations in patients with Thalassemia major

Ejemplares similares