Spinal neural tube closure depends on regulation of surface ectoderm identity and biomechanics by Grhl2

Loss or over-expression of Grainyhead-like transcription factors (Grhl) prevents closure of the neural tube but the mechanism underlying this is unclear. Here, the authors show that Grhl2 regulates murine posterior-neuropore closure via changes in the identity and biomechanics of the non-neural, sur...

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Autores principales:	Evanthia Nikolopoulou, Caroline S. Hirst, Gabriel Galea, Christina Venturini, Dale Moulding, Abigail R. Marshall, Ana Rolo, Sandra C. P. De Castro, Andrew J. Copp, Nicholas D. E. Greene
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/997301dd14a44cfe8d45c82ba65c8e2b
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spelling	oai:doaj.org-article:997301dd14a44cfe8d45c82ba65c8e2b2021-12-02T14:39:37ZSpinal neural tube closure depends on regulation of surface ectoderm identity and biomechanics by Grhl210.1038/s41467-019-10164-62041-1723https://doaj.org/article/997301dd14a44cfe8d45c82ba65c8e2b2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10164-6https://doaj.org/toc/2041-1723Loss or over-expression of Grainyhead-like transcription factors (Grhl) prevents closure of the neural tube but the mechanism underlying this is unclear. Here, the authors show that Grhl2 regulates murine posterior-neuropore closure via changes in the identity and biomechanics of the non-neural, surface ectoderm cells.Evanthia NikolopoulouCaroline S. HirstGabriel GaleaChristina VenturiniDale MouldingAbigail R. MarshallAna RoloSandra C. P. De CastroAndrew J. CoppNicholas D. E. GreeneNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Evanthia Nikolopoulou Caroline S. Hirst Gabriel Galea Christina Venturini Dale Moulding Abigail R. Marshall Ana Rolo Sandra C. P. De Castro Andrew J. Copp Nicholas D. E. Greene Spinal neural tube closure depends on regulation of surface ectoderm identity and biomechanics by Grhl2
description	Loss or over-expression of Grainyhead-like transcription factors (Grhl) prevents closure of the neural tube but the mechanism underlying this is unclear. Here, the authors show that Grhl2 regulates murine posterior-neuropore closure via changes in the identity and biomechanics of the non-neural, surface ectoderm cells.
format	article
author	Evanthia Nikolopoulou Caroline S. Hirst Gabriel Galea Christina Venturini Dale Moulding Abigail R. Marshall Ana Rolo Sandra C. P. De Castro Andrew J. Copp Nicholas D. E. Greene
author_facet	Evanthia Nikolopoulou Caroline S. Hirst Gabriel Galea Christina Venturini Dale Moulding Abigail R. Marshall Ana Rolo Sandra C. P. De Castro Andrew J. Copp Nicholas D. E. Greene
author_sort	Evanthia Nikolopoulou
title	Spinal neural tube closure depends on regulation of surface ectoderm identity and biomechanics by Grhl2
title_short	Spinal neural tube closure depends on regulation of surface ectoderm identity and biomechanics by Grhl2
title_full	Spinal neural tube closure depends on regulation of surface ectoderm identity and biomechanics by Grhl2
title_fullStr	Spinal neural tube closure depends on regulation of surface ectoderm identity and biomechanics by Grhl2
title_full_unstemmed	Spinal neural tube closure depends on regulation of surface ectoderm identity and biomechanics by Grhl2
title_sort	spinal neural tube closure depends on regulation of surface ectoderm identity and biomechanics by grhl2
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/997301dd14a44cfe8d45c82ba65c8e2b
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Spinal neural tube closure depends on regulation of surface ectoderm identity and biomechanics by Grhl2

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