Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precision
Severe falciparum malaria has substantially affected human evolution. Genetic association studies of patients with clinically defined severe malaria and matched population controls have helped characterise human genetic susceptibility to severe malaria, but phenotypic imprecision compromises discove...
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Main Authors: | James A Watson, Carolyne M Ndila, Sophie Uyoga, Alexander Macharia, Gideon Nyutu, Shebe Mohammed, Caroline Ngetsa, Neema Mturi, Norbert Peshu, Benjamin Tsofa, Kirk Rockett, Stije Leopold, Hugh Kingston, Elizabeth C George, Kathryn Maitland, Nicholas PJ Day, Arjen M Dondorp, Philip Bejon, Thomas N Williams, Chris C Holmes, Nicholas J White |
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Format: | article |
Language: | EN |
Published: |
eLife Sciences Publications Ltd
2021
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Subjects: | |
Online Access: | https://doaj.org/article/9975f68439c94b6da46fbbde7cbac9a5 |
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