THE CONTENT OF POLYUNSATURATED FATTY ACIDS (PUFAS) IN MEMBRANES OF ERYTHROCYTES IN CHILDREN WITH ATOPIC DERMATITIS (AD) OF VARYING SEVERITY

Currently, there is a hypothesis about the presence of congenital metabolic disorders of polyunsaturated fatty acids (PUFAs), which plays a role in the pathogenesis of atopic dermatitis. It is postulated deficit of deltafunction 6-desaturase, which leads to a lack of content in the cell membranes of...

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Autores principales:	S. Yu. Tereshchenko, L. V. Lapteva
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2012
Materias:	children atopy fatty acids erythrocytes Science Q
Acceso en línea:	https://doaj.org/article/99783fa3c3054c5abd6d3d79a935765c
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spelling	oai:doaj.org-article:99783fa3c3054c5abd6d3d79a935765c2021-11-23T06:14:19ZTHE CONTENT OF POLYUNSATURATED FATTY ACIDS (PUFAS) IN MEMBRANES OF ERYTHROCYTES IN CHILDREN WITH ATOPIC DERMATITIS (AD) OF VARYING SEVERITY2541-94202587-9596https://doaj.org/article/99783fa3c3054c5abd6d3d79a935765c2012-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/917https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Currently, there is a hypothesis about the presence of congenital metabolic disorders of polyunsaturated fatty acids (PUFAs), which plays a role in the pathogenesis of atopic dermatitis. It is postulated deficit of deltafunction 6-desaturase, which leads to a lack of content in the cell membranes of derivatives of linoleic acid (gamma-linolenic acid (GLA) and arachidonic acid digomolinolenovoy). In addition, it is suggested a deficit of ω3-PUFA in atopic diseases. The composition of fatty acids of red blood cells in children with AD. Obtained by reduction of 14:0, 16:1 ω7, 18:1ω9 and 18:3ω6 (GLA) acids in erythrocyte membranes in children. The relationship between the level of GLA to the severity of AD. The complete absence of HCA in the membranes was detected in 83 % of children with severe AD, 60 % with mild AD and 41 % of healthy children, p1-3 = 0,033 It is suggested that the decrease in GLA in cell membranes may be the target of therapeutic intervention in children with AD. At the same time, our study found no evidence of ω3-PUFA deficiency in children with AD.S. Yu. TereshchenkoL. V. LaptevaScientific Сentre for Family Health and Human Reproduction Problemsarticlechildrenatopyfatty acidserythrocytesScienceQRUActa Biomedica Scientifica, Vol 0, Iss 3(2), Pp 200-203 (2012)
institution	DOAJ
collection	DOAJ
language	RU
topic	children atopy fatty acids erythrocytes Science Q
spellingShingle	children atopy fatty acids erythrocytes Science Q S. Yu. Tereshchenko L. V. Lapteva THE CONTENT OF POLYUNSATURATED FATTY ACIDS (PUFAS) IN MEMBRANES OF ERYTHROCYTES IN CHILDREN WITH ATOPIC DERMATITIS (AD) OF VARYING SEVERITY
description	Currently, there is a hypothesis about the presence of congenital metabolic disorders of polyunsaturated fatty acids (PUFAs), which plays a role in the pathogenesis of atopic dermatitis. It is postulated deficit of deltafunction 6-desaturase, which leads to a lack of content in the cell membranes of derivatives of linoleic acid (gamma-linolenic acid (GLA) and arachidonic acid digomolinolenovoy). In addition, it is suggested a deficit of ω3-PUFA in atopic diseases. The composition of fatty acids of red blood cells in children with AD. Obtained by reduction of 14:0, 16:1 ω7, 18:1ω9 and 18:3ω6 (GLA) acids in erythrocyte membranes in children. The relationship between the level of GLA to the severity of AD. The complete absence of HCA in the membranes was detected in 83 % of children with severe AD, 60 % with mild AD and 41 % of healthy children, p1-3 = 0,033 It is suggested that the decrease in GLA in cell membranes may be the target of therapeutic intervention in children with AD. At the same time, our study found no evidence of ω3-PUFA deficiency in children with AD.
format	article
author	S. Yu. Tereshchenko L. V. Lapteva
author_facet	S. Yu. Tereshchenko L. V. Lapteva
author_sort	S. Yu. Tereshchenko
title	THE CONTENT OF POLYUNSATURATED FATTY ACIDS (PUFAS) IN MEMBRANES OF ERYTHROCYTES IN CHILDREN WITH ATOPIC DERMATITIS (AD) OF VARYING SEVERITY
title_short	THE CONTENT OF POLYUNSATURATED FATTY ACIDS (PUFAS) IN MEMBRANES OF ERYTHROCYTES IN CHILDREN WITH ATOPIC DERMATITIS (AD) OF VARYING SEVERITY
title_full	THE CONTENT OF POLYUNSATURATED FATTY ACIDS (PUFAS) IN MEMBRANES OF ERYTHROCYTES IN CHILDREN WITH ATOPIC DERMATITIS (AD) OF VARYING SEVERITY
title_fullStr	THE CONTENT OF POLYUNSATURATED FATTY ACIDS (PUFAS) IN MEMBRANES OF ERYTHROCYTES IN CHILDREN WITH ATOPIC DERMATITIS (AD) OF VARYING SEVERITY
title_full_unstemmed	THE CONTENT OF POLYUNSATURATED FATTY ACIDS (PUFAS) IN MEMBRANES OF ERYTHROCYTES IN CHILDREN WITH ATOPIC DERMATITIS (AD) OF VARYING SEVERITY
title_sort	content of polyunsaturated fatty acids (pufas) in membranes of erythrocytes in children with atopic dermatitis (ad) of varying severity
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2012
url	https://doaj.org/article/99783fa3c3054c5abd6d3d79a935765c
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THE CONTENT OF POLYUNSATURATED FATTY ACIDS (PUFAS) IN MEMBRANES OF ERYTHROCYTES IN CHILDREN WITH ATOPIC DERMATITIS (AD) OF VARYING SEVERITY

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