Acute strength training promotes responses in whole blood circulating levels of miR-146a among older adults with type 2 diabetes mellitus

Gilberto Santos Morais Junior,1 Vinicius Carolino Souza,2 Wilcelly Machado-Silva,2 Adriane Dallanora Henriques,2 Andressa Melo Alves,1 Danilo Barbosa Morais,1 Otávio Toledo Nóbrega,2 Ciro José Brito,3 Roberto Jerônimo dos Santos Silva11Universidade Federal...

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Autores principales:	Morais Junior GS, Souza VC, Machado-Silva W, Henriques AD, Melo Alves A, Barbosa Morais D, Nóbrega OT, Brito CJ, Santos Silva RJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Diabetes physical exercise microRNA elderly biomarker. Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/99786e327b9e46c299d79ea56af4ba8a
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spelling	oai:doaj.org-article:99786e327b9e46c299d79ea56af4ba8a2021-12-02T00:51:40ZAcute strength training promotes responses in whole blood circulating levels of miR-146a among older adults with type 2 diabetes mellitus1178-1998https://doaj.org/article/99786e327b9e46c299d79ea56af4ba8a2017-09-01T00:00:00Zhttps://www.dovepress.com/acute-strength-training-promotes-responses-in-whole-blood-circulating--peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Gilberto Santos Morais Junior,1 Vinicius Carolino Souza,2 Wilcelly Machado-Silva,2 Adriane Dallanora Henriques,2 Andressa Melo Alves,1 Danilo Barbosa Morais,1 Otávio Toledo Nóbrega,2 Ciro José Brito,3 Roberto Jerônimo dos Santos Silva11Universidade Federal de Sergipe (UFS), São Cristóvão, Sergipe, 2Universidade de Brasília, Brasília, Distrito Federal, 3Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, BrazilAbstract: Type 2 diabetes mellitus (T2DM) consists of a set of metabolic and endocrine disorders which evolve into deficiency in insulin action and hyperglycemia. Physical exercise is considered the main intervention to prevent and control T2DM. Literature has suggested that circulating microRNAs (miRs) help to understand responses to physical activity among diabetic patients. Thus, the aim of this study was to analyze the acute effect of two interventions (strength and cardiovascular) on the total, whole blood circulating concentrations of miR-126, miR-146a and miR-155 in older adults with and without T2DM. A total of 23 male and female older adults (68.2±5.3 years) participated in the trial, 13 of whom presented with controlled T2DM and 10 were nondiabetics. They underwent both interventions separately, performed with intensity from 60% to 70% of reserve heart rate. Glucose and miRs levels were quantified and compared across groups with baseline titers as covariables. Diabetic patients showed more reduction in serum blood glucose than nondiabetics, with a great magnitude of reduction after the strength training intervention, which was paralleled by a positive change of the whole blood circulating levels of miR-146a, but not of the other miRs. Our report supports evidence that miR-146a levels in peripheral blood leukocytes are negatively associated with a state of insulin resistance, which is suggested as a novel marker to trace response to antidiabetic interventions.Keywords: diabetes, physical exercise, microRNA, elderly, biomarkerMorais Junior GSSouza VCMachado-Silva WHenriques ADMelo Alves ABarbosa Morais DNóbrega OTBrito CJSantos Silva RJDove Medical PressarticleDiabetesphysical exercisemicroRNAelderlybiomarker.GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 12, Pp 1443-1450 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diabetes physical exercise microRNA elderly biomarker. Geriatrics RC952-954.6
spellingShingle	Diabetes physical exercise microRNA elderly biomarker. Geriatrics RC952-954.6 Morais Junior GS Souza VC Machado-Silva W Henriques AD Melo Alves A Barbosa Morais D Nóbrega OT Brito CJ Santos Silva RJ Acute strength training promotes responses in whole blood circulating levels of miR-146a among older adults with type 2 diabetes mellitus
description	Gilberto Santos Morais Junior,1 Vinicius Carolino Souza,2 Wilcelly Machado-Silva,2 Adriane Dallanora Henriques,2 Andressa Melo Alves,1 Danilo Barbosa Morais,1 Otávio Toledo Nóbrega,2 Ciro José Brito,3 Roberto Jerônimo dos Santos Silva11Universidade Federal de Sergipe (UFS), São Cristóvão, Sergipe, 2Universidade de Brasília, Brasília, Distrito Federal, 3Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, BrazilAbstract: Type 2 diabetes mellitus (T2DM) consists of a set of metabolic and endocrine disorders which evolve into deficiency in insulin action and hyperglycemia. Physical exercise is considered the main intervention to prevent and control T2DM. Literature has suggested that circulating microRNAs (miRs) help to understand responses to physical activity among diabetic patients. Thus, the aim of this study was to analyze the acute effect of two interventions (strength and cardiovascular) on the total, whole blood circulating concentrations of miR-126, miR-146a and miR-155 in older adults with and without T2DM. A total of 23 male and female older adults (68.2±5.3 years) participated in the trial, 13 of whom presented with controlled T2DM and 10 were nondiabetics. They underwent both interventions separately, performed with intensity from 60% to 70% of reserve heart rate. Glucose and miRs levels were quantified and compared across groups with baseline titers as covariables. Diabetic patients showed more reduction in serum blood glucose than nondiabetics, with a great magnitude of reduction after the strength training intervention, which was paralleled by a positive change of the whole blood circulating levels of miR-146a, but not of the other miRs. Our report supports evidence that miR-146a levels in peripheral blood leukocytes are negatively associated with a state of insulin resistance, which is suggested as a novel marker to trace response to antidiabetic interventions.Keywords: diabetes, physical exercise, microRNA, elderly, biomarker
format	article
author	Morais Junior GS Souza VC Machado-Silva W Henriques AD Melo Alves A Barbosa Morais D Nóbrega OT Brito CJ Santos Silva RJ
author_facet	Morais Junior GS Souza VC Machado-Silva W Henriques AD Melo Alves A Barbosa Morais D Nóbrega OT Brito CJ Santos Silva RJ
author_sort	Morais Junior GS
title	Acute strength training promotes responses in whole blood circulating levels of miR-146a among older adults with type 2 diabetes mellitus
title_short	Acute strength training promotes responses in whole blood circulating levels of miR-146a among older adults with type 2 diabetes mellitus
title_full	Acute strength training promotes responses in whole blood circulating levels of miR-146a among older adults with type 2 diabetes mellitus
title_fullStr	Acute strength training promotes responses in whole blood circulating levels of miR-146a among older adults with type 2 diabetes mellitus
title_full_unstemmed	Acute strength training promotes responses in whole blood circulating levels of miR-146a among older adults with type 2 diabetes mellitus
title_sort	acute strength training promotes responses in whole blood circulating levels of mir-146a among older adults with type 2 diabetes mellitus
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/99786e327b9e46c299d79ea56af4ba8a
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Acute strength training promotes responses in whole blood circulating levels of miR-146a among older adults with type 2 diabetes mellitus

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