POLYPRENYL PHOSPHATES AS ADJUVANTS, POLARIZING THE IMMUNE RESPONSE TO Th1

Abstract. The attempts to decrease a toxic action of Freund complete adjuvant have led to development of new emulsion adjuvant compositions. More often they are based on metabolizable oil (squalene) with addition the Tween 80 (Polisorbate 80) as an emulsifier. The third component is an immunomodulat...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	A. V. Pronin, S. V. Ozherelkov, A. V. Deyeva, A. V. Sanin, A. N. Narovljansky
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2014
Materias:	adjuvant polyprenol virus infections Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/997a505ca302445c9356a0fec44b8be6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:997a505ca302445c9356a0fec44b8be6
record_format	dspace
spelling	oai:doaj.org-article:997a505ca302445c9356a0fec44b8be62021-11-22T07:09:45ZPOLYPRENYL PHOSPHATES AS ADJUVANTS, POLARIZING THE IMMUNE RESPONSE TO Th12220-76192313-739810.15789/2220-7619-2012-3-645-650https://doaj.org/article/997a505ca302445c9356a0fec44b8be62014-07-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/80https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Abstract. The attempts to decrease a toxic action of Freund complete adjuvant have led to development of new emulsion adjuvant compositions. More often they are based on metabolizable oil (squalene) with addition the Tween 80 (Polisorbate 80) as an emulsifier. The third component is an immunomodulator. Adjuvants, intended for prevention of virus infections, should include the immunomodulators polarizing the immune response to Th1. From this point of view adjuvant based on a colloidal solution prepared by means of the Tween 80 from polyprenyl phasphates of fir needles (Phosprenyl) can be rather perspective. The last one, as well as squalene, is constructed by isoprene links, but has them not 6, but 16 that essentially reduces its toxicity. The obtained data shows that Phosprenyl essentially enhances efficiency of vaccination in such virus infections as tick born encephalitis, bird flu, poliomyelitis and polarizes the immune response to Th1.A. V. ProninS. V. OzherelkovA. V. DeyevaA. V. SaninA. N. NarovljanskySankt-Peterburg : NIIÈM imeni Pasteraarticleadjuvantpolyprenolvirus infectionsInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 2, Iss 3, Pp 645-650 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	adjuvant polyprenol virus infections Infectious and parasitic diseases RC109-216
spellingShingle	adjuvant polyprenol virus infections Infectious and parasitic diseases RC109-216 A. V. Pronin S. V. Ozherelkov A. V. Deyeva A. V. Sanin A. N. Narovljansky POLYPRENYL PHOSPHATES AS ADJUVANTS, POLARIZING THE IMMUNE RESPONSE TO Th1
description	Abstract. The attempts to decrease a toxic action of Freund complete adjuvant have led to development of new emulsion adjuvant compositions. More often they are based on metabolizable oil (squalene) with addition the Tween 80 (Polisorbate 80) as an emulsifier. The third component is an immunomodulator. Adjuvants, intended for prevention of virus infections, should include the immunomodulators polarizing the immune response to Th1. From this point of view adjuvant based on a colloidal solution prepared by means of the Tween 80 from polyprenyl phasphates of fir needles (Phosprenyl) can be rather perspective. The last one, as well as squalene, is constructed by isoprene links, but has them not 6, but 16 that essentially reduces its toxicity. The obtained data shows that Phosprenyl essentially enhances efficiency of vaccination in such virus infections as tick born encephalitis, bird flu, poliomyelitis and polarizes the immune response to Th1.
format	article
author	A. V. Pronin S. V. Ozherelkov A. V. Deyeva A. V. Sanin A. N. Narovljansky
author_facet	A. V. Pronin S. V. Ozherelkov A. V. Deyeva A. V. Sanin A. N. Narovljansky
author_sort	A. V. Pronin
title	POLYPRENYL PHOSPHATES AS ADJUVANTS, POLARIZING THE IMMUNE RESPONSE TO Th1
title_short	POLYPRENYL PHOSPHATES AS ADJUVANTS, POLARIZING THE IMMUNE RESPONSE TO Th1
title_full	POLYPRENYL PHOSPHATES AS ADJUVANTS, POLARIZING THE IMMUNE RESPONSE TO Th1
title_fullStr	POLYPRENYL PHOSPHATES AS ADJUVANTS, POLARIZING THE IMMUNE RESPONSE TO Th1
title_full_unstemmed	POLYPRENYL PHOSPHATES AS ADJUVANTS, POLARIZING THE IMMUNE RESPONSE TO Th1
title_sort	polyprenyl phosphates as adjuvants, polarizing the immune response to th1
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2014
url	https://doaj.org/article/997a505ca302445c9356a0fec44b8be6
work_keys_str_mv	AT avpronin polyprenylphosphatesasadjuvantspolarizingtheimmuneresponsetoth1 AT svozherelkov polyprenylphosphatesasadjuvantspolarizingtheimmuneresponsetoth1 AT avdeyeva polyprenylphosphatesasadjuvantspolarizingtheimmuneresponsetoth1 AT avsanin polyprenylphosphatesasadjuvantspolarizingtheimmuneresponsetoth1 AT annarovljansky polyprenylphosphatesasadjuvantspolarizingtheimmuneresponsetoth1
_version_	1718418055638286336

POLYPRENYL PHOSPHATES AS ADJUVANTS, POLARIZING THE IMMUNE RESPONSE TO Th1

Ejemplares similares