Mapping Compound Databases to Disease Maps—A MINERVA Plugin for CandActBase

The MINERVA platform is currently the most widely used platform for visualizing and providing access to disease maps. Disease maps are systems biological maps of molecular interactions relevant in a certain disease context, where they can be used to support drug discovery. For this purpose, we exten...

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Autores principales:	Liza Vinhoven, Malte Voskamp, Manuel Manfred Nietert
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	systems medicine disease maps drug targets drug repurposing knowledge repository data integration Medicine R
Acceso en línea:	https://doaj.org/article/997c0466772446ab82b5d36cc1683464
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id	oai:doaj.org-article:997c0466772446ab82b5d36cc1683464
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spelling	oai:doaj.org-article:997c0466772446ab82b5d36cc16834642021-11-25T18:06:53ZMapping Compound Databases to Disease Maps—A MINERVA Plugin for CandActBase10.3390/jpm111110722075-4426https://doaj.org/article/997c0466772446ab82b5d36cc16834642021-10-01T00:00:00Zhttps://www.mdpi.com/2075-4426/11/11/1072https://doaj.org/toc/2075-4426The MINERVA platform is currently the most widely used platform for visualizing and providing access to disease maps. Disease maps are systems biological maps of molecular interactions relevant in a certain disease context, where they can be used to support drug discovery. For this purpose, we extended MINERVA’s own drug and chemical search using the MINERVA plugin starter kit. We developed a plugin to provide a linkage between disease maps in MINERVA and application-specific databases of candidate therapeutics. The plugin has three main functionalities; one shows all the targets of all the compounds in the database, the second is a compound-based search to highlight targets of specific compounds, and the third can be used to find compounds that affect a certain target. As a use case, we applied the plugin to link a disease map and compound database we previously established in the context of cystic fibrosis and, herein, point out possible issues and difficulties. The plugin is publicly available on GitLab; the use-case application to cystic fibrosis, connecting disease maps and the compound database CandActCFTR, is available online.Liza VinhovenMalte VoskampManuel Manfred NietertMDPI AGarticlesystems medicinedisease mapsdrug targetsdrug repurposingknowledge repositorydata integrationMedicineRENJournal of Personalized Medicine, Vol 11, Iss 1072, p 1072 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	systems medicine disease maps drug targets drug repurposing knowledge repository data integration Medicine R
spellingShingle	systems medicine disease maps drug targets drug repurposing knowledge repository data integration Medicine R Liza Vinhoven Malte Voskamp Manuel Manfred Nietert Mapping Compound Databases to Disease Maps—A MINERVA Plugin for CandActBase
description	The MINERVA platform is currently the most widely used platform for visualizing and providing access to disease maps. Disease maps are systems biological maps of molecular interactions relevant in a certain disease context, where they can be used to support drug discovery. For this purpose, we extended MINERVA’s own drug and chemical search using the MINERVA plugin starter kit. We developed a plugin to provide a linkage between disease maps in MINERVA and application-specific databases of candidate therapeutics. The plugin has three main functionalities; one shows all the targets of all the compounds in the database, the second is a compound-based search to highlight targets of specific compounds, and the third can be used to find compounds that affect a certain target. As a use case, we applied the plugin to link a disease map and compound database we previously established in the context of cystic fibrosis and, herein, point out possible issues and difficulties. The plugin is publicly available on GitLab; the use-case application to cystic fibrosis, connecting disease maps and the compound database CandActCFTR, is available online.
format	article
author	Liza Vinhoven Malte Voskamp Manuel Manfred Nietert
author_facet	Liza Vinhoven Malte Voskamp Manuel Manfred Nietert
author_sort	Liza Vinhoven
title	Mapping Compound Databases to Disease Maps—A MINERVA Plugin for CandActBase
title_short	Mapping Compound Databases to Disease Maps—A MINERVA Plugin for CandActBase
title_full	Mapping Compound Databases to Disease Maps—A MINERVA Plugin for CandActBase
title_fullStr	Mapping Compound Databases to Disease Maps—A MINERVA Plugin for CandActBase
title_full_unstemmed	Mapping Compound Databases to Disease Maps—A MINERVA Plugin for CandActBase
title_sort	mapping compound databases to disease maps—a minerva plugin for candactbase
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/997c0466772446ab82b5d36cc1683464
work_keys_str_mv	AT lizavinhoven mappingcompounddatabasestodiseasemapsaminervapluginforcandactbase AT maltevoskamp mappingcompounddatabasestodiseasemapsaminervapluginforcandactbase AT manuelmanfrednietert mappingcompounddatabasestodiseasemapsaminervapluginforcandactbase
_version_	1718411632114139136

Mapping Compound Databases to Disease Maps—A MINERVA Plugin for CandActBase

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