Lymphatic leakage after pelvic lymphadenectomy for cervical cancer: a retrospective case-control study

Abstract Background The study aims to evaluate the clinical features and management of postoperative lymphatic leakage (PLL) in patients with cervical cancer who received pelvic lymphadenectomy. Methods This retrospective study screened consecutive patients with cervical cancer (stage Ia2-IIb). Resu...

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Autores principales:	Li Chen, Liang Lin, Ling Li, Zuolian Xie, Haixin He, Cuibo Lin, Jian Chen, An Lin
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Lymphatic leakage Lymph node dissection Cervical cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/9988377439b0429db8eeb59d1ddaad55
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spelling	oai:doaj.org-article:9988377439b0429db8eeb59d1ddaad552021-11-21T12:30:32ZLymphatic leakage after pelvic lymphadenectomy for cervical cancer: a retrospective case-control study10.1186/s12885-021-08984-11471-2407https://doaj.org/article/9988377439b0429db8eeb59d1ddaad552021-11-01T00:00:00Zhttps://doi.org/10.1186/s12885-021-08984-1https://doaj.org/toc/1471-2407Abstract Background The study aims to evaluate the clinical features and management of postoperative lymphatic leakage (PLL) in patients with cervical cancer who received pelvic lymphadenectomy. Methods This retrospective study screened consecutive patients with cervical cancer (stage Ia2-IIb). Results Among 3427 cases screened, 63 patients (1.8%) were diagnosed with PLL, which manifested as persistent abdominal drainage (42/63, 66.7%), chylous ascites (12/63, 19.0%) or vaginal drainage (9/63, 14.3%). Median time from surgery to onset of PLL was 6 days (range, 4–21 days). All cases resolved in a median 10 days (range, 3–56 days) after conservative treatment; although one case experienced recurrence of vaginal drainage after 26 days, this also resolved after conservative therapy. Multivariate analysis showed that two cycles of neoadjuvant chemotherapy (odds ratio [OR], 3.283; 95% confidence interval [95%CI], 1.289–8.360; P = 0.013), a decrease in hemoglobin level of ≥20 and < 30 g/L (OR, 6.175; 95%CI, 1.033–10.919; P = 0.046) or ≥ 30 g/L (OR, 8.467; 95%CI, 1.248–17.426; P = 0.029), and postoperative albumin level ≥ 30 and < 35 g/L (OR, 2.552; 95%CI, 1.112–5.857; P = 0.027) or < 30 g/L (OR, 5.517; 95%CI, 2.047–18.148; P = 0.012) were associated with PLL. Conclusion Neoadjuvant chemotherapy, postoperative anemia and postoperative hypoproteinemia are risk factors for PLL.Li ChenLiang LinLing LiZuolian XieHaixin HeCuibo LinJian ChenAn LinBMCarticleLymphatic leakageLymph node dissectionCervical cancerNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBMC Cancer, Vol 21, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Lymphatic leakage Lymph node dissection Cervical cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Lymphatic leakage Lymph node dissection Cervical cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Li Chen Liang Lin Ling Li Zuolian Xie Haixin He Cuibo Lin Jian Chen An Lin Lymphatic leakage after pelvic lymphadenectomy for cervical cancer: a retrospective case-control study
description	Abstract Background The study aims to evaluate the clinical features and management of postoperative lymphatic leakage (PLL) in patients with cervical cancer who received pelvic lymphadenectomy. Methods This retrospective study screened consecutive patients with cervical cancer (stage Ia2-IIb). Results Among 3427 cases screened, 63 patients (1.8%) were diagnosed with PLL, which manifested as persistent abdominal drainage (42/63, 66.7%), chylous ascites (12/63, 19.0%) or vaginal drainage (9/63, 14.3%). Median time from surgery to onset of PLL was 6 days (range, 4–21 days). All cases resolved in a median 10 days (range, 3–56 days) after conservative treatment; although one case experienced recurrence of vaginal drainage after 26 days, this also resolved after conservative therapy. Multivariate analysis showed that two cycles of neoadjuvant chemotherapy (odds ratio [OR], 3.283; 95% confidence interval [95%CI], 1.289–8.360; P = 0.013), a decrease in hemoglobin level of ≥20 and < 30 g/L (OR, 6.175; 95%CI, 1.033–10.919; P = 0.046) or ≥ 30 g/L (OR, 8.467; 95%CI, 1.248–17.426; P = 0.029), and postoperative albumin level ≥ 30 and < 35 g/L (OR, 2.552; 95%CI, 1.112–5.857; P = 0.027) or < 30 g/L (OR, 5.517; 95%CI, 2.047–18.148; P = 0.012) were associated with PLL. Conclusion Neoadjuvant chemotherapy, postoperative anemia and postoperative hypoproteinemia are risk factors for PLL.
format	article
author	Li Chen Liang Lin Ling Li Zuolian Xie Haixin He Cuibo Lin Jian Chen An Lin
author_facet	Li Chen Liang Lin Ling Li Zuolian Xie Haixin He Cuibo Lin Jian Chen An Lin
author_sort	Li Chen
title	Lymphatic leakage after pelvic lymphadenectomy for cervical cancer: a retrospective case-control study
title_short	Lymphatic leakage after pelvic lymphadenectomy for cervical cancer: a retrospective case-control study
title_full	Lymphatic leakage after pelvic lymphadenectomy for cervical cancer: a retrospective case-control study
title_fullStr	Lymphatic leakage after pelvic lymphadenectomy for cervical cancer: a retrospective case-control study
title_full_unstemmed	Lymphatic leakage after pelvic lymphadenectomy for cervical cancer: a retrospective case-control study
title_sort	lymphatic leakage after pelvic lymphadenectomy for cervical cancer: a retrospective case-control study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/9988377439b0429db8eeb59d1ddaad55
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Lymphatic leakage after pelvic lymphadenectomy for cervical cancer: a retrospective case-control study

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