PROPHYLACTIC EFFECT OF COENZYME Q10 ON GROSS PARAMETERS OF RAT TESTIS EXPOSED TO MOSQUITO COIL SMOKE INHALATION

Objective: To determine the toxic effect of mosquito coil smoke inhalation on gross parameters of rat testis and explore the protective effect of Coenzyme Q10on testicular toxicity profile. Study Design: Laboratory-based experimental study. Place and Duration of Study: Department of Anatomy Army Me...

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Autores principales:	Muhammad Fahad Atta, Khadija Qamar, Maria Iram, Saba Saleem Safdar, Tayyaba Faisal, Maryam Shan
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2021
Materias:	allethrin coenzyme q10 mosquito coil relative tissue body weight index testis weight Medicine R Medicine (General) R5-920
Acceso en línea:	https://doi.org/10.51253/pafmj.v71i2.5954 https://doaj.org/article/9988d9e0f1b748e6a855166014c7d535
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spelling	oai:doaj.org-article:9988d9e0f1b748e6a855166014c7d5352021-12-02T19:07:06ZPROPHYLACTIC EFFECT OF COENZYME Q10 ON GROSS PARAMETERS OF RAT TESTIS EXPOSED TO MOSQUITO COIL SMOKE INHALATIONhttps://doi.org/10.51253/pafmj.v71i2.59540030-96482411-8842https://doaj.org/article/9988d9e0f1b748e6a855166014c7d5352021-04-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/5954https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine the toxic effect of mosquito coil smoke inhalation on gross parameters of rat testis and explore the protective effect of Coenzyme Q10on testicular toxicity profile. Study Design: Laboratory-based experimental study. Place and Duration of Study: Department of Anatomy Army Medical College, Rawalpindi in collaboration with National Institute of Health, Islamabad, from Jan 2020 to Dec 2020. Methodology: This study was carried out among 30 male Sprague Dawley rats, distributed into three groups as 10 rats/group; group A served as control group, rats in group B were exposed to allethrin-based mosquito coil smoke 4hours/day for 12 weeks. Rats in group C were administered Coenzyme Q10 (10 mg/kg/day) via oral gavage for 12 weeks along with mosquito coil smoke exposure. At the end of study, gross parameters of body weight gain, testicular weight and volume, and relative tissue body weight index of testis were compared among groups. Results: Rats exposed to mosquito coil smoke alone showed significantly less weight gain (p<0.001)), testicular weight (p<0.001), volume (p<0.001), and relative tissue body weight index (p<0.001) as compared to control group. Rats administered Coenzyme Q10 along with mosquito coil smoke exposure exhibited significantly higher weight gain (p<0.001), testicular weight (p<0.001), volume (p<0.001) and relative tissue body weight index (p<0.001) as compared to rats exposed to mosquito coil smoke alone. Conclusion: Long-term inhalation of allethrin-based mosquito coil smoke caused testicular atrophy among rats, as evident by reduced testicular weight, volume and relative tissue body weight index. Whereas, prophylactic oral administration of Coenzyme Q10 among rats exposed to mosquito coil smoke prevented testicular toxicity.Muhammad Fahad AttaKhadija QamarMaria IramSaba Saleem SafdarTayyaba FaisalMaryam ShanArmy Medical College Rawalpindiarticleallethrincoenzyme q10mosquito coilrelative tissue body weight indextestisweightMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 71, Iss 2, Pp 427-432 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	allethrin coenzyme q10 mosquito coil relative tissue body weight index testis weight Medicine R Medicine (General) R5-920
spellingShingle	allethrin coenzyme q10 mosquito coil relative tissue body weight index testis weight Medicine R Medicine (General) R5-920 Muhammad Fahad Atta Khadija Qamar Maria Iram Saba Saleem Safdar Tayyaba Faisal Maryam Shan PROPHYLACTIC EFFECT OF COENZYME Q10 ON GROSS PARAMETERS OF RAT TESTIS EXPOSED TO MOSQUITO COIL SMOKE INHALATION
description	Objective: To determine the toxic effect of mosquito coil smoke inhalation on gross parameters of rat testis and explore the protective effect of Coenzyme Q10on testicular toxicity profile. Study Design: Laboratory-based experimental study. Place and Duration of Study: Department of Anatomy Army Medical College, Rawalpindi in collaboration with National Institute of Health, Islamabad, from Jan 2020 to Dec 2020. Methodology: This study was carried out among 30 male Sprague Dawley rats, distributed into three groups as 10 rats/group; group A served as control group, rats in group B were exposed to allethrin-based mosquito coil smoke 4hours/day for 12 weeks. Rats in group C were administered Coenzyme Q10 (10 mg/kg/day) via oral gavage for 12 weeks along with mosquito coil smoke exposure. At the end of study, gross parameters of body weight gain, testicular weight and volume, and relative tissue body weight index of testis were compared among groups. Results: Rats exposed to mosquito coil smoke alone showed significantly less weight gain (p<0.001)), testicular weight (p<0.001), volume (p<0.001), and relative tissue body weight index (p<0.001) as compared to control group. Rats administered Coenzyme Q10 along with mosquito coil smoke exposure exhibited significantly higher weight gain (p<0.001), testicular weight (p<0.001), volume (p<0.001) and relative tissue body weight index (p<0.001) as compared to rats exposed to mosquito coil smoke alone. Conclusion: Long-term inhalation of allethrin-based mosquito coil smoke caused testicular atrophy among rats, as evident by reduced testicular weight, volume and relative tissue body weight index. Whereas, prophylactic oral administration of Coenzyme Q10 among rats exposed to mosquito coil smoke prevented testicular toxicity.
format	article
author	Muhammad Fahad Atta Khadija Qamar Maria Iram Saba Saleem Safdar Tayyaba Faisal Maryam Shan
author_facet	Muhammad Fahad Atta Khadija Qamar Maria Iram Saba Saleem Safdar Tayyaba Faisal Maryam Shan
author_sort	Muhammad Fahad Atta
title	PROPHYLACTIC EFFECT OF COENZYME Q10 ON GROSS PARAMETERS OF RAT TESTIS EXPOSED TO MOSQUITO COIL SMOKE INHALATION
title_short	PROPHYLACTIC EFFECT OF COENZYME Q10 ON GROSS PARAMETERS OF RAT TESTIS EXPOSED TO MOSQUITO COIL SMOKE INHALATION
title_full	PROPHYLACTIC EFFECT OF COENZYME Q10 ON GROSS PARAMETERS OF RAT TESTIS EXPOSED TO MOSQUITO COIL SMOKE INHALATION
title_fullStr	PROPHYLACTIC EFFECT OF COENZYME Q10 ON GROSS PARAMETERS OF RAT TESTIS EXPOSED TO MOSQUITO COIL SMOKE INHALATION
title_full_unstemmed	PROPHYLACTIC EFFECT OF COENZYME Q10 ON GROSS PARAMETERS OF RAT TESTIS EXPOSED TO MOSQUITO COIL SMOKE INHALATION
title_sort	prophylactic effect of coenzyme q10 on gross parameters of rat testis exposed to mosquito coil smoke inhalation
publisher	Army Medical College Rawalpindi
publishDate	2021
url	https://doi.org/10.51253/pafmj.v71i2.5954 https://doaj.org/article/9988d9e0f1b748e6a855166014c7d535
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PROPHYLACTIC EFFECT OF COENZYME Q10 ON GROSS PARAMETERS OF RAT TESTIS EXPOSED TO MOSQUITO COIL SMOKE INHALATION

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