Graphene Oxide-Template Gold Nanosheets as Highly Efficient Near-Infrared Hyperthermia Agents for Cancer Therapy

Shuyi He,1– 3,* Jingyu Li,1– 3,* Mingjian Chen,1– 3 Liehua Deng,4 Yuxin Yang,1– 3 Zhaoyang Zeng,1– 3 Wei Xiong,1– 3 Xu Wu1– 3 1NHC Key Laboratory of Carcinogenesis and Key Laboratory of Carcinogenesis and Cancer Invasion of the Ch...

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Autores principales:	He S, Li J, Chen M, Deng L, Yang Y, Zeng Z, Xiong W, Wu X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	graphene oxide gold nanosheets photothermal therapy near-infrared Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/998a8d21ce044433a2766073ca853853
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spelling	oai:doaj.org-article:998a8d21ce044433a2766073ca8538532021-12-02T09:31:29ZGraphene Oxide-Template Gold Nanosheets as Highly Efficient Near-Infrared Hyperthermia Agents for Cancer Therapy1178-2013https://doaj.org/article/998a8d21ce044433a2766073ca8538532020-10-01T00:00:00Zhttps://www.dovepress.com/graphene-oxide-template-gold-nanosheets-as-highly-efficient-near-infra-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Shuyi He,1– 3,* Jingyu Li,1– 3,* Mingjian Chen,1– 3 Liehua Deng,4 Yuxin Yang,1– 3 Zhaoyang Zeng,1– 3 Wei Xiong,1– 3 Xu Wu1– 3 1NHC Key Laboratory of Carcinogenesis and Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute and School of Basic Medical Science, Central South University, Changsha, People’s Republic of China; 2Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 3Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, People’s Republic of China; 4Department of Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xu WuCentral South University, 110 Xiangya Road, Kaifu District, Changsha City, Hunan Province 410078, People’s Republic of ChinaEmail wuxu1028@csu.edu.cnIntroduction: Near-infrared (NIR) hyperthermia agents are promising in cancer photothermal therapy due to their deeper penetration ability and less side effects. Spherical gold nanoshell and graphene-based nanomaterials are two major NIR hyperthermia agents that have been reported for photothermal therapy of cancer. Herein, we constructed a two-dimensional graphene oxide-template gold nanosheet (GO@SiO2@AuNS) hybrid that could destruct cancer cells with efficient photothermal effect.Methods: Graphene oxide was coated with a layer of mesoporous silica, which provided binding sites for gold seeds. Then, seed-growth method was utilized to grow a layer of gold nanosheet to form the GO@SiO2@AuNS hybrid, which possessed great biocompatibility and high photothermal conversion efficiency.Results: With the irradiation of NIR laser (808 nm) with low power density (0.3 W/cm2), GO@SiO2@AuNS hybrid showed a photothermal conversion efficiency of 30%, leading to a temperature increase of 16.4 °C in water. Colorectal cancer cells (KM12C) were killed with the treatment of GO@SiO2@AuNS hybrid under NIR irradiation.Conclusion: The GO@SiO2@AuNS hybrid may expand the library of the 2D nanostructures based on gold for cancer photothermal therapy.Keywords: graphene oxide, gold nanosheets, photothermal therapy, near-infraredHe SLi JChen MDeng LYang YZeng ZXiong WWu XDove Medical Pressarticlegraphene oxidegold nanosheetsphotothermal therapynear-infraredMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 8451-8463 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	graphene oxide gold nanosheets photothermal therapy near-infrared Medicine (General) R5-920
spellingShingle	graphene oxide gold nanosheets photothermal therapy near-infrared Medicine (General) R5-920 He S Li J Chen M Deng L Yang Y Zeng Z Xiong W Wu X Graphene Oxide-Template Gold Nanosheets as Highly Efficient Near-Infrared Hyperthermia Agents for Cancer Therapy
description	Shuyi He,1– 3,* Jingyu Li,1– 3,* Mingjian Chen,1– 3 Liehua Deng,4 Yuxin Yang,1– 3 Zhaoyang Zeng,1– 3 Wei Xiong,1– 3 Xu Wu1– 3 1NHC Key Laboratory of Carcinogenesis and Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute and School of Basic Medical Science, Central South University, Changsha, People’s Republic of China; 2Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 3Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, People’s Republic of China; 4Department of Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xu WuCentral South University, 110 Xiangya Road, Kaifu District, Changsha City, Hunan Province 410078, People’s Republic of ChinaEmail wuxu1028@csu.edu.cnIntroduction: Near-infrared (NIR) hyperthermia agents are promising in cancer photothermal therapy due to their deeper penetration ability and less side effects. Spherical gold nanoshell and graphene-based nanomaterials are two major NIR hyperthermia agents that have been reported for photothermal therapy of cancer. Herein, we constructed a two-dimensional graphene oxide-template gold nanosheet (GO@SiO2@AuNS) hybrid that could destruct cancer cells with efficient photothermal effect.Methods: Graphene oxide was coated with a layer of mesoporous silica, which provided binding sites for gold seeds. Then, seed-growth method was utilized to grow a layer of gold nanosheet to form the GO@SiO2@AuNS hybrid, which possessed great biocompatibility and high photothermal conversion efficiency.Results: With the irradiation of NIR laser (808 nm) with low power density (0.3 W/cm2), GO@SiO2@AuNS hybrid showed a photothermal conversion efficiency of 30%, leading to a temperature increase of 16.4 °C in water. Colorectal cancer cells (KM12C) were killed with the treatment of GO@SiO2@AuNS hybrid under NIR irradiation.Conclusion: The GO@SiO2@AuNS hybrid may expand the library of the 2D nanostructures based on gold for cancer photothermal therapy.Keywords: graphene oxide, gold nanosheets, photothermal therapy, near-infrared
format	article
author	He S Li J Chen M Deng L Yang Y Zeng Z Xiong W Wu X
author_facet	He S Li J Chen M Deng L Yang Y Zeng Z Xiong W Wu X
author_sort	He S
title	Graphene Oxide-Template Gold Nanosheets as Highly Efficient Near-Infrared Hyperthermia Agents for Cancer Therapy
title_short	Graphene Oxide-Template Gold Nanosheets as Highly Efficient Near-Infrared Hyperthermia Agents for Cancer Therapy
title_full	Graphene Oxide-Template Gold Nanosheets as Highly Efficient Near-Infrared Hyperthermia Agents for Cancer Therapy
title_fullStr	Graphene Oxide-Template Gold Nanosheets as Highly Efficient Near-Infrared Hyperthermia Agents for Cancer Therapy
title_full_unstemmed	Graphene Oxide-Template Gold Nanosheets as Highly Efficient Near-Infrared Hyperthermia Agents for Cancer Therapy
title_sort	graphene oxide-template gold nanosheets as highly efficient near-infrared hyperthermia agents for cancer therapy
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/998a8d21ce044433a2766073ca853853
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Graphene Oxide-Template Gold Nanosheets as Highly Efficient Near-Infrared Hyperthermia Agents for Cancer Therapy

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