Evolutionary action and structural basis of the allosteric switch controlling β2AR functional selectivity

Ligand-induced biased signaling is thought to result in part from ligand-specific receptor conformations that cause the engagement of distinct effectors. Here the authors trace and evaluate the impact of mutations of the β2–adrenergic receptor on multiple signaling outputs to provide structural-leve...

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Autores principales:	Anne-Marie Schönegge, Jonathan Gallion, Louis-Philippe Picard, Angela D. Wilkins, Christian Le Gouill, Martin Audet, Wayne Stallaert, Martin J. Lohse, Marek Kimmel, Olivier Lichtarge, Michel Bouvier
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/998b6cae615e45acb325e0d14982a595
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spelling	oai:doaj.org-article:998b6cae615e45acb325e0d14982a5952021-12-02T13:24:04ZEvolutionary action and structural basis of the allosteric switch controlling β2AR functional selectivity10.1038/s41467-017-02257-x2041-1723https://doaj.org/article/998b6cae615e45acb325e0d14982a5952017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02257-xhttps://doaj.org/toc/2041-1723Ligand-induced biased signaling is thought to result in part from ligand-specific receptor conformations that cause the engagement of distinct effectors. Here the authors trace and evaluate the impact of mutations of the β2–adrenergic receptor on multiple signaling outputs to provide structural-level insight into the determinants of GPCR functional selectivity.Anne-Marie SchöneggeJonathan GallionLouis-Philippe PicardAngela D. WilkinsChristian Le GouillMartin AudetWayne StallaertMartin J. LohseMarek KimmelOlivier LichtargeMichel BouvierNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anne-Marie Schönegge Jonathan Gallion Louis-Philippe Picard Angela D. Wilkins Christian Le Gouill Martin Audet Wayne Stallaert Martin J. Lohse Marek Kimmel Olivier Lichtarge Michel Bouvier Evolutionary action and structural basis of the allosteric switch controlling β2AR functional selectivity
description	Ligand-induced biased signaling is thought to result in part from ligand-specific receptor conformations that cause the engagement of distinct effectors. Here the authors trace and evaluate the impact of mutations of the β2–adrenergic receptor on multiple signaling outputs to provide structural-level insight into the determinants of GPCR functional selectivity.
format	article
author	Anne-Marie Schönegge Jonathan Gallion Louis-Philippe Picard Angela D. Wilkins Christian Le Gouill Martin Audet Wayne Stallaert Martin J. Lohse Marek Kimmel Olivier Lichtarge Michel Bouvier
author_facet	Anne-Marie Schönegge Jonathan Gallion Louis-Philippe Picard Angela D. Wilkins Christian Le Gouill Martin Audet Wayne Stallaert Martin J. Lohse Marek Kimmel Olivier Lichtarge Michel Bouvier
author_sort	Anne-Marie Schönegge
title	Evolutionary action and structural basis of the allosteric switch controlling β2AR functional selectivity
title_short	Evolutionary action and structural basis of the allosteric switch controlling β2AR functional selectivity
title_full	Evolutionary action and structural basis of the allosteric switch controlling β2AR functional selectivity
title_fullStr	Evolutionary action and structural basis of the allosteric switch controlling β2AR functional selectivity
title_full_unstemmed	Evolutionary action and structural basis of the allosteric switch controlling β2AR functional selectivity
title_sort	evolutionary action and structural basis of the allosteric switch controlling β2ar functional selectivity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/998b6cae615e45acb325e0d14982a595
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Evolutionary action and structural basis of the allosteric switch controlling β2AR functional selectivity

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