The Deficits of Individual Morphological Covariance Network Architecture in Schizophrenia Patients With and Without Violence

Background: Schizophrenia is associated with a significant increase in the risk of violence, which constitutes a public health concern and contributes to stigma associated with mental illness. Although previous studies revealed structural and functional abnormalities in individuals with violent schi...

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Autores principales:	Danlin Shen, Qing Li, Jianmei Liu, Yi Liao, Yuanyuan Li, Qiyong Gong, Xiaoqi Huang, Tao Li, Jing Li, Changjian Qiu, Junmei Hu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	individual morphological covariance network graph theory schizophrenia violent gray matter volume Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/998b887cfc5a498ca29ecbaac901a1c9
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spelling	oai:doaj.org-article:998b887cfc5a498ca29ecbaac901a1c92021-11-15T05:57:51ZThe Deficits of Individual Morphological Covariance Network Architecture in Schizophrenia Patients With and Without Violence1664-064010.3389/fpsyt.2021.777447https://doaj.org/article/998b887cfc5a498ca29ecbaac901a1c92021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpsyt.2021.777447/fullhttps://doaj.org/toc/1664-0640Background: Schizophrenia is associated with a significant increase in the risk of violence, which constitutes a public health concern and contributes to stigma associated with mental illness. Although previous studies revealed structural and functional abnormalities in individuals with violent schizophrenia (VSZ), the neural basis of psychotic violence remains controversial.Methods: In this study, high-resolution structural magnetic resonance imaging (MRI) data were acquired from 18 individuals with VSZ, 23 individuals with non-VSZ (NSZ), and 22 age- and sex-matched healthy controls (HCs). Whole-brain voxel-based morphology and individual morphological covariance networks were analysed to reveal differences in gray matter volume (GMV) and individual morphological covariance network topology. Relationships among abnormal GMV, network topology, and clinical assessments were examined using correlation analyses.Results: GMV in the hypothalamus gradually decreased from HCs and NSZ to VSZ and showed significant differences between all pairs of groups. Graph theory analyses revealed that morphological covariance networks of HCs, NSZ, and VSZ exhibited small worldness. Significant differences in network topology measures, including global efficiency, shortest path length, and nodal degree, were found. Furthermore, changes in GMV and network topology were closely related to clinical performance in the NSZ and VSZ groups.Conclusions: These findings revealed the important role of local structural abnormalities of the hypothalamus and global network topological impairments in the neuropathology of NSZ and VSZ, providing new insight into the neural basis of and markers for VSZ and NSZ to facilitate future accurate clinical diagnosis and targeted treatment.Danlin ShenQing LiJianmei LiuYi LiaoYuanyuan LiQiyong GongXiaoqi HuangTao LiTao LiJing LiChangjian QiuJunmei HuFrontiers Media S.A.articleindividual morphological covariance networkgraph theoryschizophreniaviolentgray matter volumePsychiatryRC435-571ENFrontiers in Psychiatry, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	individual morphological covariance network graph theory schizophrenia violent gray matter volume Psychiatry RC435-571
spellingShingle	individual morphological covariance network graph theory schizophrenia violent gray matter volume Psychiatry RC435-571 Danlin Shen Qing Li Jianmei Liu Yi Liao Yuanyuan Li Qiyong Gong Xiaoqi Huang Tao Li Tao Li Jing Li Changjian Qiu Junmei Hu The Deficits of Individual Morphological Covariance Network Architecture in Schizophrenia Patients With and Without Violence
description	Background: Schizophrenia is associated with a significant increase in the risk of violence, which constitutes a public health concern and contributes to stigma associated with mental illness. Although previous studies revealed structural and functional abnormalities in individuals with violent schizophrenia (VSZ), the neural basis of psychotic violence remains controversial.Methods: In this study, high-resolution structural magnetic resonance imaging (MRI) data were acquired from 18 individuals with VSZ, 23 individuals with non-VSZ (NSZ), and 22 age- and sex-matched healthy controls (HCs). Whole-brain voxel-based morphology and individual morphological covariance networks were analysed to reveal differences in gray matter volume (GMV) and individual morphological covariance network topology. Relationships among abnormal GMV, network topology, and clinical assessments were examined using correlation analyses.Results: GMV in the hypothalamus gradually decreased from HCs and NSZ to VSZ and showed significant differences between all pairs of groups. Graph theory analyses revealed that morphological covariance networks of HCs, NSZ, and VSZ exhibited small worldness. Significant differences in network topology measures, including global efficiency, shortest path length, and nodal degree, were found. Furthermore, changes in GMV and network topology were closely related to clinical performance in the NSZ and VSZ groups.Conclusions: These findings revealed the important role of local structural abnormalities of the hypothalamus and global network topological impairments in the neuropathology of NSZ and VSZ, providing new insight into the neural basis of and markers for VSZ and NSZ to facilitate future accurate clinical diagnosis and targeted treatment.
format	article
author	Danlin Shen Qing Li Jianmei Liu Yi Liao Yuanyuan Li Qiyong Gong Xiaoqi Huang Tao Li Tao Li Jing Li Changjian Qiu Junmei Hu
author_facet	Danlin Shen Qing Li Jianmei Liu Yi Liao Yuanyuan Li Qiyong Gong Xiaoqi Huang Tao Li Tao Li Jing Li Changjian Qiu Junmei Hu
author_sort	Danlin Shen
title	The Deficits of Individual Morphological Covariance Network Architecture in Schizophrenia Patients With and Without Violence
title_short	The Deficits of Individual Morphological Covariance Network Architecture in Schizophrenia Patients With and Without Violence
title_full	The Deficits of Individual Morphological Covariance Network Architecture in Schizophrenia Patients With and Without Violence
title_fullStr	The Deficits of Individual Morphological Covariance Network Architecture in Schizophrenia Patients With and Without Violence
title_full_unstemmed	The Deficits of Individual Morphological Covariance Network Architecture in Schizophrenia Patients With and Without Violence
title_sort	deficits of individual morphological covariance network architecture in schizophrenia patients with and without violence
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/998b887cfc5a498ca29ecbaac901a1c9
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The Deficits of Individual Morphological Covariance Network Architecture in Schizophrenia Patients With and Without Violence

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