Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders

Mutations in the mechanotransduction channel component TMC1/2 cause deafness. Here, the authors use a synthetic AAV to replace TMC1 and 2 in the inner ear and show restoration of cochlear and vestibular function, of neuronal reponses in the auditory cortex and of hearing and balance in mice.

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Autores principales:	Carl A. Nist-Lund, Bifeng Pan, Amy Patterson, Yukako Asai, Tianwen Chen, Wu Zhou, Hong Zhu, Sandra Romero, Jennifer Resnik, Daniel B. Polley, Gwenaelle S. Géléoc, Jeffrey R. Holt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/998ee4b6a33b41c587d88c8b399215ea
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spelling	oai:doaj.org-article:998ee4b6a33b41c587d88c8b399215ea2021-12-02T14:39:59ZImproved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders10.1038/s41467-018-08264-w2041-1723https://doaj.org/article/998ee4b6a33b41c587d88c8b399215ea2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08264-whttps://doaj.org/toc/2041-1723Mutations in the mechanotransduction channel component TMC1/2 cause deafness. Here, the authors use a synthetic AAV to replace TMC1 and 2 in the inner ear and show restoration of cochlear and vestibular function, of neuronal reponses in the auditory cortex and of hearing and balance in mice.Carl A. Nist-LundBifeng PanAmy PattersonYukako AsaiTianwen ChenWu ZhouHong ZhuSandra RomeroJennifer ResnikDaniel B. PolleyGwenaelle S. GéléocJeffrey R. HoltNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Carl A. Nist-Lund Bifeng Pan Amy Patterson Yukako Asai Tianwen Chen Wu Zhou Hong Zhu Sandra Romero Jennifer Resnik Daniel B. Polley Gwenaelle S. Géléoc Jeffrey R. Holt Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders
description	Mutations in the mechanotransduction channel component TMC1/2 cause deafness. Here, the authors use a synthetic AAV to replace TMC1 and 2 in the inner ear and show restoration of cochlear and vestibular function, of neuronal reponses in the auditory cortex and of hearing and balance in mice.
format	article
author	Carl A. Nist-Lund Bifeng Pan Amy Patterson Yukako Asai Tianwen Chen Wu Zhou Hong Zhu Sandra Romero Jennifer Resnik Daniel B. Polley Gwenaelle S. Géléoc Jeffrey R. Holt
author_facet	Carl A. Nist-Lund Bifeng Pan Amy Patterson Yukako Asai Tianwen Chen Wu Zhou Hong Zhu Sandra Romero Jennifer Resnik Daniel B. Polley Gwenaelle S. Géléoc Jeffrey R. Holt
author_sort	Carl A. Nist-Lund
title	Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders
title_short	Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders
title_full	Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders
title_fullStr	Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders
title_full_unstemmed	Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders
title_sort	improved tmc1 gene therapy restores hearing and balance in mice with genetic inner ear disorders
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/998ee4b6a33b41c587d88c8b399215ea
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Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders

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