Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders
Mutations in the mechanotransduction channel component TMC1/2 cause deafness. Here, the authors use a synthetic AAV to replace TMC1 and 2 in the inner ear and show restoration of cochlear and vestibular function, of neuronal reponses in the auditory cortex and of hearing and balance in mice.
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2019
|
| Subjects: | |
| Online Access: | https://doaj.org/article/998ee4b6a33b41c587d88c8b399215ea |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|