Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms
FLT3 is commonly mutated in acute myeloid leukaemia and treatment with FLT3 inhibitors often ends with relapse. Here, the authors perform exome sequencing of samples from patients treated with the FLT3 inhibitor, crenolanib, to show that resistance occurs due to diverse molecular mechanisms, not pri...
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Nature Portfolio
2019
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oai:doaj.org-article:998f439604e74cef95464ecda676fa5a2021-12-02T14:39:41ZClinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms10.1038/s41467-018-08263-x2041-1723https://doaj.org/article/998f439604e74cef95464ecda676fa5a2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08263-xhttps://doaj.org/toc/2041-1723FLT3 is commonly mutated in acute myeloid leukaemia and treatment with FLT3 inhibitors often ends with relapse. Here, the authors perform exome sequencing of samples from patients treated with the FLT3 inhibitor, crenolanib, to show that resistance occurs due to diverse molecular mechanisms, not primarily due to secondary FLT3 mutations.Haijiao ZhangSamantha SavageAnna Reister SchultzDaniel BottomlyLibbey WhiteErik SegerdellBeth WilmotShannon K. McWeeneyChristopher A. EideTamilla NechiporukAmy CarlosRachel HensonChenwei LinRobert SearlesHoang HoYee Ling LamRichard SweatCourtney FollitVinay JainEvan LindGautam BorthakurGuillermo Garcia-ManeroFarhad RavandiHagop M. KantarjianJorge CortesRobert CollinsDaelynn R. BuelowSharyn D. BakerBrian J. DrukerJeffrey W. TynerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019) |
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DOAJ |
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EN |
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Science Q |
| spellingShingle |
Science Q Haijiao Zhang Samantha Savage Anna Reister Schultz Daniel Bottomly Libbey White Erik Segerdell Beth Wilmot Shannon K. McWeeney Christopher A. Eide Tamilla Nechiporuk Amy Carlos Rachel Henson Chenwei Lin Robert Searles Hoang Ho Yee Ling Lam Richard Sweat Courtney Follit Vinay Jain Evan Lind Gautam Borthakur Guillermo Garcia-Manero Farhad Ravandi Hagop M. Kantarjian Jorge Cortes Robert Collins Daelynn R. Buelow Sharyn D. Baker Brian J. Druker Jeffrey W. Tyner Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms |
| description |
FLT3 is commonly mutated in acute myeloid leukaemia and treatment with FLT3 inhibitors often ends with relapse. Here, the authors perform exome sequencing of samples from patients treated with the FLT3 inhibitor, crenolanib, to show that resistance occurs due to diverse molecular mechanisms, not primarily due to secondary FLT3 mutations. |
| format |
article |
| author |
Haijiao Zhang Samantha Savage Anna Reister Schultz Daniel Bottomly Libbey White Erik Segerdell Beth Wilmot Shannon K. McWeeney Christopher A. Eide Tamilla Nechiporuk Amy Carlos Rachel Henson Chenwei Lin Robert Searles Hoang Ho Yee Ling Lam Richard Sweat Courtney Follit Vinay Jain Evan Lind Gautam Borthakur Guillermo Garcia-Manero Farhad Ravandi Hagop M. Kantarjian Jorge Cortes Robert Collins Daelynn R. Buelow Sharyn D. Baker Brian J. Druker Jeffrey W. Tyner |
| author_facet |
Haijiao Zhang Samantha Savage Anna Reister Schultz Daniel Bottomly Libbey White Erik Segerdell Beth Wilmot Shannon K. McWeeney Christopher A. Eide Tamilla Nechiporuk Amy Carlos Rachel Henson Chenwei Lin Robert Searles Hoang Ho Yee Ling Lam Richard Sweat Courtney Follit Vinay Jain Evan Lind Gautam Borthakur Guillermo Garcia-Manero Farhad Ravandi Hagop M. Kantarjian Jorge Cortes Robert Collins Daelynn R. Buelow Sharyn D. Baker Brian J. Druker Jeffrey W. Tyner |
| author_sort |
Haijiao Zhang |
| title |
Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms |
| title_short |
Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms |
| title_full |
Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms |
| title_fullStr |
Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms |
| title_full_unstemmed |
Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms |
| title_sort |
clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/998f439604e74cef95464ecda676fa5a |
| work_keys_str_mv |
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