Surface area in the insula was associated with 28-month functional outcome in first-episode psychosis

Abstract Many studies have tested the relationship between demographic, clinical, and psychobiological measurements and clinical outcomes in ultra-high risk for psychosis (UHR) and first-episode psychosis (FEP). However, no study has investigated the relationship between multi-modal measurements and...

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Autores principales:	Shinsuke Koike, Mao Fujioka, Yoshihiro Satomura, Daisuke Koshiyama, Mariko Tada, Eisuke Sakakibara, Naohiro Okada, Yosuke Takano, Norichika Iwashiro, Tatsunobu Natsubori, Yinghan Zhu, Osamu Abe, Kenji Kirihara, Hidenori Yamasue, Kiyoto Kasai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/9995403c8b6744659c63ce3819cb4789
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spelling	oai:doaj.org-article:9995403c8b6744659c63ce3819cb47892021-12-05T12:10:25ZSurface area in the insula was associated with 28-month functional outcome in first-episode psychosis10.1038/s41537-021-00186-92334-265Xhttps://doaj.org/article/9995403c8b6744659c63ce3819cb47892021-11-01T00:00:00Zhttps://doi.org/10.1038/s41537-021-00186-9https://doaj.org/toc/2334-265XAbstract Many studies have tested the relationship between demographic, clinical, and psychobiological measurements and clinical outcomes in ultra-high risk for psychosis (UHR) and first-episode psychosis (FEP). However, no study has investigated the relationship between multi-modal measurements and long-term outcomes for >2 years. Thirty-eight individuals with UHR and 29 patients with FEP were measured using one or more modalities (cognitive battery, electrophysiological response, structural magnetic resonance imaging, and functional near-infrared spectroscopy). We explored the characteristics associated with 13- and 28-month clinical outcomes. In UHR, the cortical surface area in the left orbital part of the inferior frontal gyrus was negatively associated with 13-month disorganized symptoms. In FEP, the cortical surface area in the left insula was positively associated with 28-month global social function. The left inferior frontal gyrus and insula are well-known structural brain characteristics in schizophrenia, and future studies on the pathological mechanism of structural alteration would provide a clearer understanding of the disease.Shinsuke KoikeMao FujiokaYoshihiro SatomuraDaisuke KoshiyamaMariko TadaEisuke SakakibaraNaohiro OkadaYosuke TakanoNorichika IwashiroTatsunobu NatsuboriYinghan ZhuOsamu AbeKenji KiriharaHidenori YamasueKiyoto KasaiNature PortfolioarticlePsychiatryRC435-571ENnpj Schizophrenia, Vol 7, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Psychiatry RC435-571
spellingShingle	Psychiatry RC435-571 Shinsuke Koike Mao Fujioka Yoshihiro Satomura Daisuke Koshiyama Mariko Tada Eisuke Sakakibara Naohiro Okada Yosuke Takano Norichika Iwashiro Tatsunobu Natsubori Yinghan Zhu Osamu Abe Kenji Kirihara Hidenori Yamasue Kiyoto Kasai Surface area in the insula was associated with 28-month functional outcome in first-episode psychosis
description	Abstract Many studies have tested the relationship between demographic, clinical, and psychobiological measurements and clinical outcomes in ultra-high risk for psychosis (UHR) and first-episode psychosis (FEP). However, no study has investigated the relationship between multi-modal measurements and long-term outcomes for >2 years. Thirty-eight individuals with UHR and 29 patients with FEP were measured using one or more modalities (cognitive battery, electrophysiological response, structural magnetic resonance imaging, and functional near-infrared spectroscopy). We explored the characteristics associated with 13- and 28-month clinical outcomes. In UHR, the cortical surface area in the left orbital part of the inferior frontal gyrus was negatively associated with 13-month disorganized symptoms. In FEP, the cortical surface area in the left insula was positively associated with 28-month global social function. The left inferior frontal gyrus and insula are well-known structural brain characteristics in schizophrenia, and future studies on the pathological mechanism of structural alteration would provide a clearer understanding of the disease.
format	article
author	Shinsuke Koike Mao Fujioka Yoshihiro Satomura Daisuke Koshiyama Mariko Tada Eisuke Sakakibara Naohiro Okada Yosuke Takano Norichika Iwashiro Tatsunobu Natsubori Yinghan Zhu Osamu Abe Kenji Kirihara Hidenori Yamasue Kiyoto Kasai
author_facet	Shinsuke Koike Mao Fujioka Yoshihiro Satomura Daisuke Koshiyama Mariko Tada Eisuke Sakakibara Naohiro Okada Yosuke Takano Norichika Iwashiro Tatsunobu Natsubori Yinghan Zhu Osamu Abe Kenji Kirihara Hidenori Yamasue Kiyoto Kasai
author_sort	Shinsuke Koike
title	Surface area in the insula was associated with 28-month functional outcome in first-episode psychosis
title_short	Surface area in the insula was associated with 28-month functional outcome in first-episode psychosis
title_full	Surface area in the insula was associated with 28-month functional outcome in first-episode psychosis
title_fullStr	Surface area in the insula was associated with 28-month functional outcome in first-episode psychosis
title_full_unstemmed	Surface area in the insula was associated with 28-month functional outcome in first-episode psychosis
title_sort	surface area in the insula was associated with 28-month functional outcome in first-episode psychosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9995403c8b6744659c63ce3819cb4789
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Surface area in the insula was associated with 28-month functional outcome in first-episode psychosis

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