IgGFc-binding protein in pregnancies complicated by spontaneous preterm delivery: a retrospective cohort study

Abstract To determine the IgGFc-binding protein (FcgammaBP) concentration in amniotic and cervical fluids in preterm prelabor rupture of membranes (PPROM) and preterm labor with intact membranes (PTL) and to assess the diagnostic indices of FcgammaBP to predict intra-amniotic infection (the presence...

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Autores principales:	Jaroslav Stranik, Marian Kacerovsky, Ondrej Soucek, Martina Kolackova, Ivana Musilova, Lenka Pliskova, Radka Bolehovska, Pavel Bostik, Jana Matulova, Bo Jacobsson, Ctirad Andrys
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9996645937e14387a64d3880701d86d0
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spelling	oai:doaj.org-article:9996645937e14387a64d3880701d86d02021-12-02T17:05:12ZIgGFc-binding protein in pregnancies complicated by spontaneous preterm delivery: a retrospective cohort study10.1038/s41598-021-85473-22045-2322https://doaj.org/article/9996645937e14387a64d3880701d86d02021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85473-2https://doaj.org/toc/2045-2322Abstract To determine the IgGFc-binding protein (FcgammaBP) concentration in amniotic and cervical fluids in preterm prelabor rupture of membranes (PPROM) and preterm labor with intact membranes (PTL) and to assess the diagnostic indices of FcgammaBP to predict intra-amniotic infection (the presence of both microbial invasion of the amniotic cavity and intra-amniotic inflammation). In this study, we included 170 and 79 women with PPROM and PTL, respectively. Paired cervical and amniotic fluid samples were obtained using a Dacron polyester swab and transabdominal amniocentesis, respectively. The FcgammaBP concentrations in the samples were assessed using an enzyme-linked immunosorbent assay. The presence of intra-amniotic infection was associated with elevated FcgammaBP concentrations in pregnancies with PPROM and PTL [PPROM—presence: 86 ng/mL vs. absence: 13 ng/mL, p < 0.0001, area under receiver operating characteristic curve (AUC) = 0.94; PTL—presence: 140 ng/mL vs. absence: 22 ng/mL, p < 0.0001, AUC = 0.86]. In cervical fluid, the concentrations of FcgammaBP were elevated in the presence of intra-amniotic infection in pregnancies with PPROM only (presence: 345 ng/mL vs. absence: 60 ng/mL, p < 0.0001, AUC = 0.93). FcgammaBP in amniotic fluid might be a marker of intra-amniotic infection in women with both PPROM and PTL However, in cervical fluid, it is only observed in women with PPROM.Jaroslav StranikMarian KacerovskyOndrej SoucekMartina KolackovaIvana MusilovaLenka PliskovaRadka BolehovskaPavel BostikJana MatulovaBo JacobssonCtirad AndrysNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jaroslav Stranik Marian Kacerovsky Ondrej Soucek Martina Kolackova Ivana Musilova Lenka Pliskova Radka Bolehovska Pavel Bostik Jana Matulova Bo Jacobsson Ctirad Andrys IgGFc-binding protein in pregnancies complicated by spontaneous preterm delivery: a retrospective cohort study
description	Abstract To determine the IgGFc-binding protein (FcgammaBP) concentration in amniotic and cervical fluids in preterm prelabor rupture of membranes (PPROM) and preterm labor with intact membranes (PTL) and to assess the diagnostic indices of FcgammaBP to predict intra-amniotic infection (the presence of both microbial invasion of the amniotic cavity and intra-amniotic inflammation). In this study, we included 170 and 79 women with PPROM and PTL, respectively. Paired cervical and amniotic fluid samples were obtained using a Dacron polyester swab and transabdominal amniocentesis, respectively. The FcgammaBP concentrations in the samples were assessed using an enzyme-linked immunosorbent assay. The presence of intra-amniotic infection was associated with elevated FcgammaBP concentrations in pregnancies with PPROM and PTL [PPROM—presence: 86 ng/mL vs. absence: 13 ng/mL, p < 0.0001, area under receiver operating characteristic curve (AUC) = 0.94; PTL—presence: 140 ng/mL vs. absence: 22 ng/mL, p < 0.0001, AUC = 0.86]. In cervical fluid, the concentrations of FcgammaBP were elevated in the presence of intra-amniotic infection in pregnancies with PPROM only (presence: 345 ng/mL vs. absence: 60 ng/mL, p < 0.0001, AUC = 0.93). FcgammaBP in amniotic fluid might be a marker of intra-amniotic infection in women with both PPROM and PTL However, in cervical fluid, it is only observed in women with PPROM.
format	article
author	Jaroslav Stranik Marian Kacerovsky Ondrej Soucek Martina Kolackova Ivana Musilova Lenka Pliskova Radka Bolehovska Pavel Bostik Jana Matulova Bo Jacobsson Ctirad Andrys
author_facet	Jaroslav Stranik Marian Kacerovsky Ondrej Soucek Martina Kolackova Ivana Musilova Lenka Pliskova Radka Bolehovska Pavel Bostik Jana Matulova Bo Jacobsson Ctirad Andrys
author_sort	Jaroslav Stranik
title	IgGFc-binding protein in pregnancies complicated by spontaneous preterm delivery: a retrospective cohort study
title_short	IgGFc-binding protein in pregnancies complicated by spontaneous preterm delivery: a retrospective cohort study
title_full	IgGFc-binding protein in pregnancies complicated by spontaneous preterm delivery: a retrospective cohort study
title_fullStr	IgGFc-binding protein in pregnancies complicated by spontaneous preterm delivery: a retrospective cohort study
title_full_unstemmed	IgGFc-binding protein in pregnancies complicated by spontaneous preterm delivery: a retrospective cohort study
title_sort	iggfc-binding protein in pregnancies complicated by spontaneous preterm delivery: a retrospective cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9996645937e14387a64d3880701d86d0
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IgGFc-binding protein in pregnancies complicated by spontaneous preterm delivery: a retrospective cohort study

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