Discovery of new molecular subtypes in oesophageal adenocarcinoma.

A large number of patients suffering from oesophageal adenocarcinomas do not respond to conventional chemotherapy; therefore, it is necessary to identify new predictive biomarkers and patient signatures to improve patient outcomes and therapy selections. We analysed 87 formalin-fixed and paraffin-em...

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Autores principales:	Daniela Berg, Claudia Wolff, Rupert Langer, Tibor Schuster, Marcus Feith, Julia Slotta-Huspenina, Katharina Malinowsky, Karl-Friedrich Becker
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/999b038ba7a44b0f988a417d09262fb7
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spelling	oai:doaj.org-article:999b038ba7a44b0f988a417d09262fb72021-11-04T06:07:56ZDiscovery of new molecular subtypes in oesophageal adenocarcinoma.1932-620310.1371/journal.pone.0023985https://doaj.org/article/999b038ba7a44b0f988a417d09262fb72011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21966358/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203A large number of patients suffering from oesophageal adenocarcinomas do not respond to conventional chemotherapy; therefore, it is necessary to identify new predictive biomarkers and patient signatures to improve patient outcomes and therapy selections. We analysed 87 formalin-fixed and paraffin-embedded (FFPE) oesophageal adenocarcinoma tissue samples with a reverse phase protein array (RPPA) to examine the expression of 17 cancer-related signalling molecules. Protein expression levels were analysed by unsupervised hierarchical clustering and correlated with clinicopathological parameters and overall patient survival. Proteomic analyses revealed a new, very promising molecular subtype of oesophageal adenocarcinoma patients characterised by low levels of the HSP27 family proteins and high expression of those of the HER family with positive lymph nodes, distant metastases and short overall survival. After confirmation in other independent studies, our results could be the foundation for the development of a Her2-targeted treatment option for this new patient subgroup of oesophageal adenocarcinoma.Daniela BergClaudia WolffRupert LangerTibor SchusterMarcus FeithJulia Slotta-HuspeninaKatharina MalinowskyKarl-Friedrich BeckerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 9, p e23985 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daniela Berg Claudia Wolff Rupert Langer Tibor Schuster Marcus Feith Julia Slotta-Huspenina Katharina Malinowsky Karl-Friedrich Becker Discovery of new molecular subtypes in oesophageal adenocarcinoma.
description	A large number of patients suffering from oesophageal adenocarcinomas do not respond to conventional chemotherapy; therefore, it is necessary to identify new predictive biomarkers and patient signatures to improve patient outcomes and therapy selections. We analysed 87 formalin-fixed and paraffin-embedded (FFPE) oesophageal adenocarcinoma tissue samples with a reverse phase protein array (RPPA) to examine the expression of 17 cancer-related signalling molecules. Protein expression levels were analysed by unsupervised hierarchical clustering and correlated with clinicopathological parameters and overall patient survival. Proteomic analyses revealed a new, very promising molecular subtype of oesophageal adenocarcinoma patients characterised by low levels of the HSP27 family proteins and high expression of those of the HER family with positive lymph nodes, distant metastases and short overall survival. After confirmation in other independent studies, our results could be the foundation for the development of a Her2-targeted treatment option for this new patient subgroup of oesophageal adenocarcinoma.
format	article
author	Daniela Berg Claudia Wolff Rupert Langer Tibor Schuster Marcus Feith Julia Slotta-Huspenina Katharina Malinowsky Karl-Friedrich Becker
author_facet	Daniela Berg Claudia Wolff Rupert Langer Tibor Schuster Marcus Feith Julia Slotta-Huspenina Katharina Malinowsky Karl-Friedrich Becker
author_sort	Daniela Berg
title	Discovery of new molecular subtypes in oesophageal adenocarcinoma.
title_short	Discovery of new molecular subtypes in oesophageal adenocarcinoma.
title_full	Discovery of new molecular subtypes in oesophageal adenocarcinoma.
title_fullStr	Discovery of new molecular subtypes in oesophageal adenocarcinoma.
title_full_unstemmed	Discovery of new molecular subtypes in oesophageal adenocarcinoma.
title_sort	discovery of new molecular subtypes in oesophageal adenocarcinoma.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/999b038ba7a44b0f988a417d09262fb7
work_keys_str_mv	AT danielaberg discoveryofnewmolecularsubtypesinoesophagealadenocarcinoma AT claudiawolff discoveryofnewmolecularsubtypesinoesophagealadenocarcinoma AT rupertlanger discoveryofnewmolecularsubtypesinoesophagealadenocarcinoma AT tiborschuster discoveryofnewmolecularsubtypesinoesophagealadenocarcinoma AT marcusfeith discoveryofnewmolecularsubtypesinoesophagealadenocarcinoma AT juliaslottahuspenina discoveryofnewmolecularsubtypesinoesophagealadenocarcinoma AT katharinamalinowsky discoveryofnewmolecularsubtypesinoesophagealadenocarcinoma AT karlfriedrichbecker discoveryofnewmolecularsubtypesinoesophagealadenocarcinoma
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Discovery of new molecular subtypes in oesophageal adenocarcinoma.

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