Evaluation of a step-by-step approach to frozen section diagnosis in ovarian masses

Background: Ovarian cancer forms a significant proportion of cancer-related mortality in females. It is often detected late due to non-specific clinical presentation. Radiology and tumor markers may indicate an ovarian mass. However, exact diagnosis requires pathological evaluation, which may not be...

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Autores principales:	Ashumi Gupta, Neelam Jain
Formato:	article
Lenguaje:	EN
Publicado:	Manipal College of Medical Sciences, Pokhara 2021
Materias:	accuracy frozen section ovarian tumors Medicine R
Acceso en línea:	https://doi.org/10.3126/ajms.v12i12.39635 https://doaj.org/article/999f425edf8a4469ad57e8c075fafd0d
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spelling	oai:doaj.org-article:999f425edf8a4469ad57e8c075fafd0d2021-12-01T14:24:57ZEvaluation of a step-by-step approach to frozen section diagnosis in ovarian masseshttps://doi.org/10.3126/ajms.v12i12.396352467-91002091-0576https://doaj.org/article/999f425edf8a4469ad57e8c075fafd0d2021-12-01T00:00:00Zhttps://www.nepjol.info/index.php/AJMS/article/view/39635https://doaj.org/toc/2467-9100https://doaj.org/toc/2091-0576Background: Ovarian cancer forms a significant proportion of cancer-related mortality in females. It is often detected late due to non-specific clinical presentation. Radiology and tumor markers may indicate an ovarian mass. However, exact diagnosis requires pathological evaluation, which may not be possible before surgery. Intraoperative frozen section (FS) is, therefore, an important modality for the diagnosis of ovarian masses. Aims and Objectives: This study was conducted to study step-by-step approach along with diagnostic utility and accuracy of intraoperative FS in diagnosis of ovarian masses. Materials and Methods: Retrospective comparative analysis was done to determine the diagnostic accuracy of FS as compared to routine histopathology in the pathology department of a tertiary care hospital. Diagnostic categorization was done into benign, borderline, and malignant. Overall accuracy, sensitivity, and specificity of FS technique were calculated. Results: Out of 51 cases, FS analysis yielded accurate diagnosis in 94.1% of ovarian masses. Intraoperative FS had a sensitivity of 94.7%, specificity of 96.9%, 3.1% false-positive rate, and 5.3% false-negative rate in malignant tumors. In benign lesions, FS had 91.7% sensitivity and 100% specificity. FS had 75% sensitivity and 96.4% specificity in cases of borderline tumors. Conclusion: FS is a fairly accurate technique for intraoperative evaluation of ovarian masses. It can help in deciding the extent of surgery. It distinguishes benign and malignant tumors in most cases with high sensitivity and specificity. A methodical approach is useful in determining accurate diagnosis on FS diagnosis.Ashumi Gupta Neelam Jain Manipal College of Medical Sciences, Pokharaarticleaccuracyfrozen sectionovarian tumorsMedicineRENAsian Journal of Medical Sciences, Vol 12, Iss 12, Pp 133-139 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	accuracy frozen section ovarian tumors Medicine R
spellingShingle	accuracy frozen section ovarian tumors Medicine R Ashumi Gupta Neelam Jain Evaluation of a step-by-step approach to frozen section diagnosis in ovarian masses
description	Background: Ovarian cancer forms a significant proportion of cancer-related mortality in females. It is often detected late due to non-specific clinical presentation. Radiology and tumor markers may indicate an ovarian mass. However, exact diagnosis requires pathological evaluation, which may not be possible before surgery. Intraoperative frozen section (FS) is, therefore, an important modality for the diagnosis of ovarian masses. Aims and Objectives: This study was conducted to study step-by-step approach along with diagnostic utility and accuracy of intraoperative FS in diagnosis of ovarian masses. Materials and Methods: Retrospective comparative analysis was done to determine the diagnostic accuracy of FS as compared to routine histopathology in the pathology department of a tertiary care hospital. Diagnostic categorization was done into benign, borderline, and malignant. Overall accuracy, sensitivity, and specificity of FS technique were calculated. Results: Out of 51 cases, FS analysis yielded accurate diagnosis in 94.1% of ovarian masses. Intraoperative FS had a sensitivity of 94.7%, specificity of 96.9%, 3.1% false-positive rate, and 5.3% false-negative rate in malignant tumors. In benign lesions, FS had 91.7% sensitivity and 100% specificity. FS had 75% sensitivity and 96.4% specificity in cases of borderline tumors. Conclusion: FS is a fairly accurate technique for intraoperative evaluation of ovarian masses. It can help in deciding the extent of surgery. It distinguishes benign and malignant tumors in most cases with high sensitivity and specificity. A methodical approach is useful in determining accurate diagnosis on FS diagnosis.
format	article
author	Ashumi Gupta Neelam Jain
author_facet	Ashumi Gupta Neelam Jain
author_sort	Ashumi Gupta
title	Evaluation of a step-by-step approach to frozen section diagnosis in ovarian masses
title_short	Evaluation of a step-by-step approach to frozen section diagnosis in ovarian masses
title_full	Evaluation of a step-by-step approach to frozen section diagnosis in ovarian masses
title_fullStr	Evaluation of a step-by-step approach to frozen section diagnosis in ovarian masses
title_full_unstemmed	Evaluation of a step-by-step approach to frozen section diagnosis in ovarian masses
title_sort	evaluation of a step-by-step approach to frozen section diagnosis in ovarian masses
publisher	Manipal College of Medical Sciences, Pokhara
publishDate	2021
url	https://doi.org/10.3126/ajms.v12i12.39635 https://doaj.org/article/999f425edf8a4469ad57e8c075fafd0d
work_keys_str_mv	AT ashumigupta evaluationofastepbystepapproachtofrozensectiondiagnosisinovarianmasses AT neelamjain evaluationofastepbystepapproachtofrozensectiondiagnosisinovarianmasses
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Evaluation of a step-by-step approach to frozen section diagnosis in ovarian masses

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