Regulation of MDM2 E3 ligase-dependent vascular calcification by MSX1/2

Vascular disease: Driver of deposition of calcium salts identified The identification of a signaling pathway involved in triggering vascular calcification, the deposition of calcium phosphate crystals in blood vessels, could inform new therapeutic interventions for related cardiovascular complicatio...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Duk-Hwa Kwon, Nakwon Choe, Sera Shin, Juhee Ryu, Nacksung Kim, Gwang Hyeon Eom, Kwang-Il Nam, Hyung Seok Kim, Youngkeun Ahn, Young-Kook Kim, Woo Jin Park, Susan M. Mendrysa, Hyun Kook
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Medicine R Biochemistry QD415-436
Acceso en línea:	https://doaj.org/article/99a08d6caad7418d87e4e85719b2144a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:99a08d6caad7418d87e4e85719b2144a
record_format	dspace
spelling	oai:doaj.org-article:99a08d6caad7418d87e4e85719b2144a2021-12-05T12:24:27ZRegulation of MDM2 E3 ligase-dependent vascular calcification by MSX1/210.1038/s12276-021-00708-61226-36132092-6413https://doaj.org/article/99a08d6caad7418d87e4e85719b2144a2021-11-01T00:00:00Zhttps://doi.org/10.1038/s12276-021-00708-6https://doaj.org/toc/1226-3613https://doaj.org/toc/2092-6413Vascular disease: Driver of deposition of calcium salts identified The identification of a signaling pathway involved in triggering vascular calcification, the deposition of calcium phosphate crystals in blood vessels, could inform new therapeutic interventions for related cardiovascular complications. Vascular calcification causes significant complications in patients with metabolic syndrome, renal failure, or cardiovascular disease. In their previous work, Hyun Kook and Duk-Hwa Kwon at Chonnam National University Medical School, Jeollanamdo, Republic of Korea, and coworkers demonstrated that the E3 ligase activity of a protein called MDM2 induces calcification. Now, following further mouse trials, the team have identified an upstream signaling pathway involving several development proteins such as MSX1 and MSX2 which activate MDM2. The activation of this signaling axis leads to the degradation of a key protein that would otherwise prevent calcification. The results may provide a platform for novel therapies targeting the condition.Duk-Hwa KwonNakwon ChoeSera ShinJuhee RyuNacksung KimGwang Hyeon EomKwang-Il NamHyung Seok KimYoungkeun AhnYoung-Kook KimWoo Jin ParkSusan M. MendrysaHyun KookNature Publishing GrouparticleMedicineRBiochemistryQD415-436ENExperimental and Molecular Medicine, Vol 53, Iss 11, Pp 1781-1791 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Biochemistry QD415-436
spellingShingle	Medicine R Biochemistry QD415-436 Duk-Hwa Kwon Nakwon Choe Sera Shin Juhee Ryu Nacksung Kim Gwang Hyeon Eom Kwang-Il Nam Hyung Seok Kim Youngkeun Ahn Young-Kook Kim Woo Jin Park Susan M. Mendrysa Hyun Kook Regulation of MDM2 E3 ligase-dependent vascular calcification by MSX1/2
description	Vascular disease: Driver of deposition of calcium salts identified The identification of a signaling pathway involved in triggering vascular calcification, the deposition of calcium phosphate crystals in blood vessels, could inform new therapeutic interventions for related cardiovascular complications. Vascular calcification causes significant complications in patients with metabolic syndrome, renal failure, or cardiovascular disease. In their previous work, Hyun Kook and Duk-Hwa Kwon at Chonnam National University Medical School, Jeollanamdo, Republic of Korea, and coworkers demonstrated that the E3 ligase activity of a protein called MDM2 induces calcification. Now, following further mouse trials, the team have identified an upstream signaling pathway involving several development proteins such as MSX1 and MSX2 which activate MDM2. The activation of this signaling axis leads to the degradation of a key protein that would otherwise prevent calcification. The results may provide a platform for novel therapies targeting the condition.
format	article
author	Duk-Hwa Kwon Nakwon Choe Sera Shin Juhee Ryu Nacksung Kim Gwang Hyeon Eom Kwang-Il Nam Hyung Seok Kim Youngkeun Ahn Young-Kook Kim Woo Jin Park Susan M. Mendrysa Hyun Kook
author_facet	Duk-Hwa Kwon Nakwon Choe Sera Shin Juhee Ryu Nacksung Kim Gwang Hyeon Eom Kwang-Il Nam Hyung Seok Kim Youngkeun Ahn Young-Kook Kim Woo Jin Park Susan M. Mendrysa Hyun Kook
author_sort	Duk-Hwa Kwon
title	Regulation of MDM2 E3 ligase-dependent vascular calcification by MSX1/2
title_short	Regulation of MDM2 E3 ligase-dependent vascular calcification by MSX1/2
title_full	Regulation of MDM2 E3 ligase-dependent vascular calcification by MSX1/2
title_fullStr	Regulation of MDM2 E3 ligase-dependent vascular calcification by MSX1/2
title_full_unstemmed	Regulation of MDM2 E3 ligase-dependent vascular calcification by MSX1/2
title_sort	regulation of mdm2 e3 ligase-dependent vascular calcification by msx1/2
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/99a08d6caad7418d87e4e85719b2144a
work_keys_str_mv	AT dukhwakwon regulationofmdm2e3ligasedependentvascularcalcificationbymsx12 AT nakwonchoe regulationofmdm2e3ligasedependentvascularcalcificationbymsx12 AT serashin regulationofmdm2e3ligasedependentvascularcalcificationbymsx12 AT juheeryu regulationofmdm2e3ligasedependentvascularcalcificationbymsx12 AT nacksungkim regulationofmdm2e3ligasedependentvascularcalcificationbymsx12 AT gwanghyeoneom regulationofmdm2e3ligasedependentvascularcalcificationbymsx12 AT kwangilnam regulationofmdm2e3ligasedependentvascularcalcificationbymsx12 AT hyungseokkim regulationofmdm2e3ligasedependentvascularcalcificationbymsx12 AT youngkeunahn regulationofmdm2e3ligasedependentvascularcalcificationbymsx12 AT youngkookkim regulationofmdm2e3ligasedependentvascularcalcificationbymsx12 AT woojinpark regulationofmdm2e3ligasedependentvascularcalcificationbymsx12 AT susanmmendrysa regulationofmdm2e3ligasedependentvascularcalcificationbymsx12 AT hyunkook regulationofmdm2e3ligasedependentvascularcalcificationbymsx12
_version_	1718371973215551488

Regulation of MDM2 E3 ligase-dependent vascular calcification by MSX1/2

Ejemplares similares